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1. EP2691522 - FUNCTIONAL NUCLEIC ACID MOLECULE AND USE THEREOF

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

Claims

1. A trans-acting functional nucleic acid molecule comprising:

(a) a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased; and

(b) a regulatory sequence comprising:

(1) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 1;

(2) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 2;

(3) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 3;

(4) an RNA encoded by a DNA consisting of a nucleotide sequence selected from the group consisting of the sequences shown in the following table:

Gene with AS refseq start B2 end B2   strand subtype         Legend; cDNA cloneID_alignment Start position_ Alignent end type of Repeat element
NM_177182 973 1013 -2766 + B2_Mm 2 SINE/B 2 2 42 -153 >AK032380_973_1013 +_B2_Mm2
NM 009351 859 1044 -1470 + B2_Mm 1t SINE/B 2 2 185 -8 >AK033525_859_1044_ +_B2_Mm1t
NM_144515 1564 1718 -761 + B2_Mm 2 SINE/B 2 1 158 -37 >AK033993_1564_1718 _+_B2_Mm2
NM 198300 520 712 -1160 + B2_Mm 2 SINE/B 2 1 188 -7 >AK039361 520 712_+ _B2_Mm2
NM 028428 1801 1997 -245 + B2_Mm 1t SINE/B 2 1 193 0 >AK042841_1801_1997 _+_B2_Mm1t
NM_010661 946 1111 -1515 + B2_Mm 2 SINE/B 2 1 195 0 >AK043817_946_1111_ +_B2_Mm2
NM 007485 722 912 -417 + B2_Mm 2 SINE/B 2 1 194 -1 >AK044205_722_912_+ _B2_Mm2
NM 010633 971 1164 -67 + B2_Mm 2 SINE/B 2 1 195 0 >AK047213_971_1164_ +_B2_Mm2
NM 030207 714 787 -446 + B2_Mm 2 SINE/B 2 1 88 -107 >AK079217_714_787_+ _B2_Mm2
NM_145470 1498 1697 -1057 + B2_Mm 2 SINE/B 2 1 193 -2 >AK081722_1498_1697 _+_B2_Mm2
NM_024282 1379 1555 -2 + B2_Mm 2 SINE/B 2 2 187 -8 >AK132990_1379_1555 _+_B2_Mm2
NM 133994 1001 1057 -86 + B2_Mm 2 SINE/B 2 2 58 -137 >AK133457_1001_1057 _+_B2_Mm2
NM 133994 1057 1137 -6 + B2_Mm 2 SINE/B 2 91 171 -24 >AK133457_1057_1137 _+_B2_Mm2
NM_178244 2323 2513 -45 + B2_Mm 2 SINE/B 2 1 195 0 >AK133632_2323_2513 _+_B2_Mm2
NM 008997 734 923 -3 + B2_Mm 2 SINE/B 2 1 186 -9 >AK133808_734_923_+ _B2_Mm2
NM 080555 286 382 -4 + B2_Mm 1t SINE/B 2 75 171 -22 >AK134674_286_382_+ _B2_Mm1t
NM 010332 2428 2606 -1 + B2_Mm 2 SINE/B 2 1 183 -12 >AK135599_2428_2606 _+_B2_Mm2
NM_172467 2948 3108 -3 + B2_Mm 2 SINE/B 2 1 162 -33 >AK137583_2948_3108 _+_B2_Mm2
NM_175115 81 274 -2006 + B2_Mm 2 SINE/B 2 2 195 0 >AK138675_81_274_+_ B2_Mm2
NM_010071 3150 3339 -54 + B2_Mm 2 SINE/B 2 1 195 0 >AK155102_3150_3339 _+_B2_Mm2
NM 183014 288 442 -20 + B3A SINE/B 2 48 198 0 >AK015655_288_442_+ _B3A
NM_026555 277 435 -24 + B3A SINE/B 2 40 198 0 >AK021299_277_435_+ _B3A
NM_033077 1109 1295 -1732 + B3A SINE/B 2 5 189 -9 >AK029689_1109_1295 _+_B3A
NM 019789 1052 1211 -1195 + B3 SINE/B 2 33 196 -20 >AK030353_1052_1211 _+_B3
NM 178891 2403 2558 -3 + B3 SINE/B 2 20 176 -40 >AK030551_2403_2558 _+_B3
NM_145579 2546 2719 -346 + B3 SINE/B 2 2 206 -10 >AK031007 2546 2719 _+_B3
NM 008510 2255 2404 -429 + B3A SINE/B 2 57 198 0 >AK034030 2255 2404 _+_B3A
NM_153579 1071 1262 -798 + B3 SINE/B 2 1 214 -2 >AK035406_1071_1262 _+_B3
NM 145942 1006 1219 -681 + B3 SINE/B 2 2 216 0 >AK037188_1006_1219 _+_B3
NM_025788 1871 2045 -757 + B3 SINE/B 2 1 215 -1 >AK039409_1871_2045 _+_B3
NM 008019 877 1044 -1057 + B3 SINE/B 2 2 211 -5 >AK040162_877_1044_ +_B3
NM 001081 475 1431 1582 -6 + B3 SINE/B 2 69 216 0 >AK040401_1431_1582 _+_B3
NM 001081 475 1586 1745 -2 + B3 SINE/B 2 3 206 -10 >AK040401_1586_1745 _+_B3
NM 007485 722 810 -519 + B3 SINE/B 2 1 89 -127 >AK044205_722_810_+ _B3
NM 007485 835 912 -417 + B3 SINE/B 2 138 215 -1 >AK044205_835_912_+ _B3
NM_178794 826 959 -986 + B3A SINE/B 2 2 129 -69 >AK045196_826_959_+ _B3A
NM 008915 737 940 -298 + B3 SINE/B 2 8 201 -15 >AK046652_737_940+ _B3
NM 010633 971 1096 -135 + B3 SINE/B 2 1 129 -87 >AK047213_971_1096_ +_B3
NM 199476 3267 3405 -1039 + B3 SINE/B 2 2 149 -67 >AK047540_3267_3405 _+_B3
NM_144795 2052 2248 -546 + B3 SINE/B 2 2 210 -6 >AK048854_2052_2248 _+_B3
#N/A 1858 2028 -5 + B3A SINE/B 2 1 176 -22 >AK049524_1858_2028 _+_B3A
NM 001038 621 1207 1363 -359 + B3A SINE/B 2 2 160 -38 >AK053130_1207_1363 _+_B3A
NM_181423 1666 1733 -71 + B3A SINE/B 2 2 72 -126 >AK054359_1666_1733 _+_B3A
NM_153515 1403 1520 -470 + B3A SINE/B 2 63 183 -15 >AK078013_1403_1520 _+_B3A
NM 198415 403 623 -1212 + B3 SINE/B 2 1 216 0 >AK078328_403_623_+ B3
NM_152220 1794 1979 -561 + B3 SINE/B 2 3 213 -3 >AK078537_1794_1979 _+_B3
NM_025729 1 165 -203 + B3 SINE/B 2 15 177 -39 >AK079403_1_165_+_B 3
NM_016693 1307 1517 -13 + B3 SINE/B 2 2 216 0 >AK080235_1307_1517 _+_B3
NM_010151 814 1024 -451 + B3 SINE/B 2 2 216 0 >AK082108_814_1024_ +_B3
NM 009713 1690 1882 -5 + B3 SINE/B 2 1 199 -17 >AK082325_1690_1882 _+_B3
NM 001029 985 221 280 -1179 + B3 SINE/B 2 108 168 -48 >AK084376_221_280_+ _B3
NM 009737 1805 2005 -406 + B3 SINE/B 2 1 207 -9 >AK085337_1805_2005 _+_B3
NM 027081 984 1130 -1155 + B3 SINE/B 2 1 162 -54 >AK086470_984_1130_ +_B3
NM 018779 876 1062 -530 + B3A SINE/B 2 2 188 -10 >AK089148_876_1062_ +_B3A
NM 027919 1468 1667 -185 + B3 SINE/B 2 1 213 -3 >AK090182_1468_1667 _+_B3
NM_011034 434 608 -12 + B3 SINE/B 2 2 216 0 >AK131819_434_608_+ _B3
NM_175551 1802 1895 -513 + B3A SINE/B 2 64 176 -22 >AK132737_1802_1895 _+_B3A
NM_175551 1829 1928 -480 + B3 SINE/B 2 101 213 -3 >AK132737_1829_1928 _+_B3
NM 007921 951 1134 -1650 + B3A SINE/B 2 3 187 -11 >AK133325_951_1134_ +_B3A
NM 001039 042 1220 1315 -292 + B3A SINE/B 2 48 142 -56 >AK134755_1220_1315 _+_B3A
NM_177328 1378 1504 -285 + B3 SINE/B 2 85 216 0 >AK134874_1378_1504 _+_B3
NM 021899 1172 1259 -140 + B3 SINE/B 2 1 95 -121 >AK135206_1172_1259 _+_B3
NM 008705 1521 1717 -572 + B3A SINE/B 2 1 197 -1 >AK136279_1521_1717 _+_B3A
NM 001079 932 2116 2299 -702 + B3 SINE/B 2 6 208 -8 >AK137643_2116_2299 _+_B3
NM 001079 932 3059 3253 -2 + B3 SINE/B 2 4 205 -11 >AK137643_3059_3253 _+_B3
NM 001033 286 2524 2698 -63 + B3A SINE/B 2 4 181 -17 >AK138296 2524 2698 _+_B3A
NM 008962 928 1095 -375 + B3 SINE/B 2 1 153 -63 >AK138521_928_1095_ +_B3
NM_175349 2151 2347 -181 + B3A SINE/B 2 11 196 -2 >AK139254_2151_2347 _+_B3A
NM_177003 1277 1466 0 + B3 SINE/B 2 1 200 -16 >AK139647_1277_1466 _+_B3
NM 007965 1338 1488 -5 + B3 SINE/B 2 51 216 0 >AK140072_1338_1488 _+_B3
NM_010192 1808 1933 -45 + B3 SINE/B 2 1 126 -90 >AK140346_1808_1933 _+_B3
NM 027446 1871 1983 -2794 + B3A SINE/B 2 1 130 -68 >AK140616_1871_1983 _+_B3A
NM 027446 2318 2342 -2435 + B3A SINE/B 2 131 156 -42 >AK140616_2318_2342 _+_B3A
NM_177186 2061 2142 -351 + B3 SINE/B 2 130 211 -5 >AK142359_2061_2142 _+_B3
NM_145134 2963 3148 -1292 + B3 SINE/B 2 28 210 -6 >AK142507_2963_3148 _+_B3
NM 009890 2740 2968 -135 + B3 SINE/B 2 1 216 0 >AK142879_2740_2968 _+_B3
NM 146055 5202 5272 -94 + B3 SINE/B 2 60 141 -75 >AK143143 5202 5272 _+_B3
NM 008977 1344 1513 -645 + B3 SINE/B 2 11 205 -11 >AK143279_1344_1513 _+_B3
NM 026036 2001 2167 -272 + B3A SINE/B 2 1 169 -29 >AK149843_2001_2167 _+_B3A
NM_001159 519 1440 1548 -1422 + B3A SINE/B 2 55 163 -35 >AK157402_1440_1548 + B3A
NM_001159 519 2503 2556 -558 + B3 SINE/B 2 1 56 -160 >AK157402_2503_2556 _+_B3
NM_001159 519 2544 2616 -498 + B3 SINE/B 2 109 177 -39 >AK157402_2544_2616 _+_B3
NM_001159 519 2702 2896 -412 + B3A SINE/B 2 1 198 0 >AK157402_2702_2896 _+_B3A
NM_001110 504 1778 1909 -25 + B3 SINE/B 2 58 210 -6 >AK160921_1778_1909 _+_B3
NM 030714 2153 2335 -62 + B3 SINE/B 2 40 216 0 >AK165234_2153_2335 _+_B3
NM_025825 945 1052 -383 RC B2_Mm la SINE/B 2 -85 108 1 >AK014613_945_1052_ RC_B2_Mm1a
NM_133756 1102 1289 -246 RC B2_Mm 2 SINE/B 2 -4 191 1 >AK016234_1102_1289 _RC_B2_Mm2
NM 183294 1565 1750 -1384 RC B2_Mm la SINE/B 2 -8 185 4 >AK029702_1565_1750 _RC_B2_Mm1a
NM 009446 531 710 -2730 RC B2_Mm 2 SINE/B 2 -6 189 2 >AK030803_531_710_ R C_B2_Mm2
NM_025788 1687 1839 -963 RC B2_Mm 2 SINE/B 2 -11 184 1 >AK039409_1687_1839 _RC_B2_Mm2
NM_177785 1626 1682 -1130 RC B2_Mm 2 SINE/B 2 -4 191 137 >AK040275_1626_1682 _RC_B2_Mm2
NM_177785 1682 1739 -1073 RC B2_Mm 2 SINE/B 2 -94 101 46 >AK040275_1682_1739 _RC_B2_Mm2
NM_177785 1776 1952 -1036 RC B2_Mm 1t SINE/B 2 -13 180 2 >AK040275_1776_1952 _RC_B2_Mm1t
NM 007485 1137 1341 -192 RC B2_Mm 2 SINE/B 2 0 195 2 >AK044205_1137_1341 _RC_B2_Mm2
NM_175273 537 714 -1793 RC B2_Mm 2 SINE/B 2 -5 190 1 >AK048762_537_714_R C_B2_Mm2
NM 029409 1005 1172 -2204 RC B2_Mm 1t SINE/B 2 -14 179 1 >AK049449_1005_1172 _RC_B2_Mm1t
NM 007836 282 407 -2067 RC B2_Mm 2 SINE/B 2 -67 128 2 >AK054076_282_407_R C_B2_Mm2
NM 007836 1764 1860 -614 RC B2_Mm 2 SINE/B 2 -97 98 2 >AK054076_1764_1860 _RC_B2_Mm2
NR_ 002891 1 181 -2344 RC B2_Mm la SINE/B 2 -10 183 2 >AK076350_1_181_RC_ B2_Mm1a
NM 026500 984 1157 -1501 RC B2_Mm 2 SINE/B 2 -14 181 1 >AK076438_984_1157_ RC_B2_Mm2
NM 052994 2158 2323 -1225 RC B2_Mm 2 SINE/B 2 -4 191 8 >AK079094 2158 2323 _RC_B2_Mm2
NM_153100 1870 2057 -1774 RC B2_Mm 2 SINE/B 2 0 195 1 >AK086953_1870_2057 _RC_B2_Mm2
NM_175313 2088 2261 -2958 RC B2_Mm 2 SINE/B 2 -9 186 14 >AK132441_2088_2261 _RC_B2_Mm2
NM_001114 140 5305 5461 -1145 RC B2_Mm 2 SINE/B 2 -38 157 2 >AK133162_5305_5461 _RC_B2_Mm2
NM 009579 1059 1251 -2941 RC B2_Mm 2 SINE/B 2 0 195 1 >AK137370_1059_1251 _RC_B2_Mm2
NM 010567 1613 1794 -1882 RC B2_Mm 2 SINE/B 2 -2 193 1 >AK138181_1613_1794 _RC_B2_Mm2
NM 001008 423 2088 2222 -57 RC B2_Mm 2 SINE/B 2 -60 135 1 >AK141165_2088_2222 _RC_B2 Mm2
NM 199027 935 1064 -63 RC B2_Mm 2 SINE/B 2 -65 130 1 >AK141411_935_1064_ RC_B2_Mm2
NM 001033 316 3103 3283 -440 RC B2_Mm 2 SINE/B 2 -5 190 2 >AK145736_3103_3283 _RC_B2_Mm2
NR_ 003492 748 810 -977 RC B2_Mm la SINE/B 2 -6 187 123 >AK147092_748_810_R C_B2_Mm1a
NM 010567 935 1129 -78 RC B2_Mm 2 SINE/B 2 0 195 2 >AK148373_935_1129_ RC_B2_Mm2
NM 026115 3593 3791 -204 RC B2_Mm 2 SINE/B 2 -1 194 1 >AK155374_3593_3791 _RC_B2_Mm2
NM 010398 1080 1265 -909 RC B2_Mm 2 SINE/B 2 -8 187 1 >AK157261_1080_1265 _RC_B2_Mm2
NM 007893 764 820 -1012 RC B2_Mm 2 SINE/B 2 -94 101 47 >AK163105_764_820_R C_B2_Mm2
NM 007893 894 1062 -938 RC B2_Mm 2 SINE/B 2 -13 182 1 >AK163105_894_1062_ RC B2 Mm2
NM 007893 1390 1436 -564 RC B2_Mm 2 SINE/B 2 -5 190 137 >AK163105_1390_1436 _RC_B2_Mm2
NM 007893 1436 1490 -510 RC B2_Mm 2 SINE/B 2 -94 101 47 >AK163105_1436_1490 _RC_B2_Mm2
NM 007893 1543 1701 -299 RC B2_Mm 1t SINE/B 2 -24 169 1 >AK163105_1543_1701 _RC_B2_Mm1t
NM_177186 1783 1964 -258 RC B2_Mm 1t SINE/B 2 -7 186 2 >AK163831_1783_1964 _RC_B2_Mm1t
NM 030714 1401 1588 -809 RC B2_Mm 2 SINE/B 2 0 195 3 >AK165234_1401_1588 _RC_B2_Mm2
NM_001110 101 1253 1420 -1139 RC B2_Mm 2 SINE/B 2 -22 173 2 >AK169421_1253_1420 _RC_B2_Mm2
NM 007601 387 544 -1715 RC B3A SINE/B 2 -22 176 1 >AK016423_387_544_R C_B3A
NM_027346 1459 1690 -74 RC B3 SINE/B 2 -2 214 1 >AK019925_1459_1690 _RC_B3
NM 138664 1382 1411 -1334 RC B3A SINE/B 2 -148 50 21 >AK028982_1382_1411 _RC_B3A
NM 013840 160 290 -556 RC B3 SINE/B 2 -79 137 9 >AK029359_160_290 _R C_B3
NM 013840 774 960 -72 RC B3 SINE/B 2 -7 209 1 >AK029359_774_960_R C_B3
NM_153591 769 982 -1569 RC B3 SINE/B 2 -6 210 1 >AK032194_769_982_R C_B3
NM 028794 1926 2130 -654 RC B3 SINE/B 2 -12 204 2 >AK032215_1926_2130 _RC_B3
NM_001012 311 1317 1437 -1013 RC B3 SINE/B 2 -44 172 38 >AK034331_1317_1437 _RC_B3
NM_001012 311 1335 1437 -1013 RC B3A SINE/B 2 -54 144 38 >AK034331_1335_1437 _RC_B3A
NM_134122 1094 1205 -719 RC B3 SINE/B 2 -88 128 1 >AK035015_1094_1205 _RC_B3
NM_153579 1443 1617 -577 RC B3 SINE/B 2 -2 214 45 >AK035406_1443_1617 _RC_B3
NM_153579 1483 1633 -561 RC B3A SINE/B 2 -18 180 27 >AK035406_1483_1633 _RC_B3A
NM 001081 014 1615 1715 -218 RC B3A SINE/B 2 -88 110 1 >AK039704_1615_1715 _RC_B3A
NM_018747 432 531 -1672 RC B3A SINE/B 2 -31 167 49 >AK040672_432_531_R C_B3A
NM 176841 1677 1886 -64 RC B3 SINE/B 2 0 216 2 >AK041236_1677_1886 _RC_B3
NM_133878 1676 1882 -314 RC B3 SINE/B 2 -7 209 1 >AK041654_1676_1882 _RC_B3
NM_145215 2334 2533 -484 RC B3 SINE/B 2 0 216 3 >AK041742_2334_2533 _RC_B3
NM 145369 1132 1336 -593 RC B3 SINE/B 2 -7 209 5 >AK042861_1132_1336 _RC_B3
NM 172691 248 442 -151 RC B3A SINE/B 2 -18 180 10 >AK043958_248_442_R C_B3A
NM 007485 938 1127 -202 RC B3 SINE/B 2 -37 179 2 >AK044205_938_1127_ RC_B3
NM 007485 989 1127 -202 RC B3A SINE/B 2 -57 141 2 >AK044205_989_1127_ RC_B3A
NM 007925 592 713 -719 RC B3 SINE/B 2 -54 162 39 >AK045677_592_713_R C_B3
NM 177006 3566 3620 -1104 RC B3 SINE/B 2 -160 56 2 >AK046828_3566_3620 _RC_B3
NM 010633 431 640 -591 RC B3 SINE/B 2 -4 212 8 >AK047213_ 431_640_R C_B3
NM 010633 457 640 -591 RC B3A SINE/B 2 -7 191 8 >AK047213_457_640 _R C_B3A
NM 008842 1460 1636 -53 RC B3A SINE/B 2 -4 194 10 >AK047301_1460_1636 _RC_B3A
NM 199476 2716 2780 -1664 RC B3A SINE/B 2 -36 162 98 >AK047540_2716_2780 _RC_B3A
NM_013514 1203 1416 -311 RC B3 SINE/B 2 0 216 1 >AK048309_1203_1416 _RC_B3
NM 080793 2342 2396 -1333 RC B3A SINE/B 2 -5 193 144 >AK048747_2342_2396 RC B3A
NM 080793 2430 2530 -1199 RC B3A SINE/B 2 -55 143 47 >AK048747_2430_2530 _RC_B3A
NM 001038 621 159 275 -1447 RC B3 SINE/B 2 -56 160 34 >AK053130_159_275_R C_B3
NM 007836 1747 1860 -614 RC B3 SINE/B 2 -97 119 2 >AK054076_1747_1860 _RC_B3
NM 010878 1134 1337 -1192 RC B3 SINE/B 2 0 216 1 >AK078161_1134_1337 _RC_B3
NM 011670 521 690 -995 RC B3 SINE/B 2 -60 156 1 >AK078321_521_690_R C_B3
NM 026086 882 1046 -355 RC B3A SINE/B 2 -18 180 1 >AK079515_882_1046_ RC_B3A
NM 025396 1081 1179 -370 RC B3 SINE/B 2 -27 189 75 >AK080749_1081_1179 _RC_B3
NM 007923 2420 2567 -582 RC B3A SINE/B 2 -48 150 4 >AK086589_2420_2567 _RC_B3A
NM_028427 1420 1597 -495 RC B3 SINE/B 2 -5 211 2 >AK090347_1420_1597 _RC_B3
NM 026157 1871 2066 -1227 RC B3A SINE/B 2 0 198 5 >AK132393_1871_2066 _RC_B3A
NM_026157 2342 2408 -885 RC B3A SINE/B 2 -131 67 1 >AK132393_2342_2408 _RC_B3A
NM 026157 2473 2606 -687 RC B3A SINE/B 2 -25 173 28 >AK132393_2473_2606 _RC_B3A
NM_175313 2113 2261 -2958 RC B3 SINE/B 2 -40 176 14 >AK132441_2113_2261 _RC_B3
NM_175313 4127 4308 -948 RC B3 SINE/B 2 -6 210 28 >AK132441_4127_4308 _RC_B3
NM_024282 1137 1290 -91 RC B3A SINE/B 2 -39 159 1 >AK132990_1137_1290 _RC_B3A
NM_177328 277 358 -1283 RC B3A SINE/B 2 -56 142 66 >AK134874_277_358_R C_B3A
NM_177328 405 484 -1157 RC B3A SINE/B 2 -133 65 1 >AK134874_405_484 R C_B3A
NM_177328 545 713 -928 RC B3A SINE/B 2 -4 194 14 >AK134874_545_713_R C_B3A
NM_177328 787 971 -670 RC B3A SINE/B 2 -4 194 7 >AK134874_787_971_R C_B3A
NM 021899 161 307 -1092 RC B3A SINE/B 2 -46 152 1 >AK135206_161_307_R C_B3A
NM 010332 228 409 -1967 RC B3 SINE/B 2 -28 188 2 >AK135599_228_409_R C_B3
NM_172407 1470 1683 -74 RC B3 SINE/B 2 -5 211 2 >AK143014_1470_1683 _RC_B3
NM_ 001009 935 1389 1495 -157 RC B3 SINE/B 2 -96 120 1 >AK143784_1389_1495 _RC_B3
NM 019827 2953 3143 -1064 RC B3 SINE/B 2 -1 215 1 >AK145079_2953_3143 _RC_B3
NM_011212 2131 2283 -1263 RC B3A SINE/B 2 -47 151 2 >AK148045_2131_2283 _RC_B3A
NM 010567 984 1129 -78 RC B3A SINE/B 2 -60 138 2 >AK148373_984_1129_ RC_B3A
NM_001110 504 1406 1594 -400 RC B3A SINE/B 2 -10 188 2 >AK149403_1406_1594 _RC_B3A
NM 026036 2270 2439 0 RC B3 SINE/B 2 -4 212 27 >AK149843_2270_2439 _RC_B3
NM 010398 1292 1476 -698 RC B3A SINE/B 2 -11 187 3 >AK157261_1292_1476 _RC_B3A
NM_001110 504 1292 1362 -572 RC B3A SINE/B 2 -112 86 11 >AK160921_1292_1362 _RC_B3A
NM 007893 1080 1254 -746 RC B3 SINE/B 2 0 216 21 >AK163105_1080_1254 _RC_B3
NM 007893 1427 1491 -509 RC B3A SINE/B 2 -82 116 46 >AK163105_1427_1491 _RC_B3A
NM 030714 1954 2064 -333 RC B3 SINE/B 2 -95 121 2 >AK165234_1954_2064 _RC_B3
NM_001110 101 853 1043 -1516 RC B3 SINE/B 2 -5 211 6 >AK169421_853_1043_ RC_B3
NM_001110 101 1742 1936 -623 RC B3 SINE/B 2 -2 214 8 >AK169421_1742_1936 _RC_B3
; or

(5) an RNA which is at least 95% similar to the RNA of (1), (2), (3) or (4) and has a function of increasing the protein synthesis efficiency.


  2. A trans-acting functional nucleic acid molecule according to claim 1, wherein the target determinant sequence is located between a 5'-terminal and the regulatory sequence in the functional nucleic acid molecule.
  3. A trans-acting functional nucleic acid molecule according to claim 1 1 or 2, wherein
the target determinant sequence has at least 60% similarity to a sequence complementary to a corresponding sequence in the protein-encoding RNA or a sequence around the first 5'-terminal start codon of the protein-encoding sequence.
  4. A trans-acting functional nucleic acid molecule according to any one of claims 1 to 3, wherein the regulatory sequence of the functional nucleic acid molecule is oriented in a reverse direction relative to the direction of translation.
  5. A trans-acting functional nucleic acid molecule according to any one of claims 1 to 4, wherein the target determinant sequence is designed to be hybridizable with a 5'-UTR (untranslated region) of the protein-encoding RNA or a sequence around the first 5' - terminal start codon of the protein-encoding sequence.
  6. A method for producing a trans-acting functional nucleic acid molecule of claim 1, said method comprising the step of preparing an RNA molecule that comprises:

(a) a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased; and

(b) a regulatory sequence comprising:

(1) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 1;

(2) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 2;

(3) an RNA, which is encoded by a DNA consisting of the nucleotide sequence shown in SEQ ID No: 3;

(4) an RNA encoded by a DNA consisting of a nucleotide sequence selected from the group consisting of the sequences shown in the following table:

Gene with AS_refseq start B2 end B2   strand subtype         Legend; cDNA cloneID_alignment Start position_ Alignent end type of Repeat element
NM_177182 973 1013 -2766 + B2_Mm2 SINE/B2 2 42 -153 >AK032380_973_1013_+_B2_Mm2
NM_009351 859 1044 -1470 + B2_Mm1t SINE/B2 2 185 -8 >AK033525_859_1044_+_B2_Mm1t
NM_144515 1564 1718 -761 + B2_Mm2 SINE/B2 1 158 -37 >AK033993_1564_1718_+_B2_Mm2
NM_198300 520 712 -1160 + B2_Mm2 SINE/B2 1 188 -7 >AK039361_520_712_+_B2_Mm2
NM_028428 1801 1997 -245 + B2_Mm1t SINE/B2 1 193 0 >AK042841_1801_1997_+_B2_Mm1t
NM_010661 946 1111 -1515 + B2_Mm2 SINE/B2 1 195 0 >AK043817_946_1111_+_B2_Mm2
NM_007485 722 912 -417 + B2_Mm2 SINE/B2 1 194 -1 >AK044205_722_912_+_B2_Mm2
NM_010633 971 1164 -67 + B2_Mm2 SINE/B2 1 195 0 >AK047213_971_1164_+_B2_Mm2
NM_030207 714 787 -446 + B2_Mm2 SINE/B2 1 88 -107 >AK079217_714_787_+_B2_Mm2
NM_145470 1498 1697 -1057 + B2_Mm2 SINE/B2 1 193 -2 >AK081722_1498_1697_+_B2_Mm2
NM_024282 1379 1555 -2 + B2_Mm2 SINE/B2 2 187 -8 >AK132990_1379_1555_+_B2_Mm2
NM_ 33994 1001 1057 -86 + B2_Mm2 SINE/B2 2 58 -137 >AK133457_1001_1057_+_B2_Mm2
NM_133994 1057 1137 -6 + B2_Mm2 SINE/B2 91 171 -24 >AK133457_1057_1137_+_B2_Mm2
NM_178244 2323 2513 -45 + B2_Mm2 SINE/B2 1 195 0 >AK133632_2323_2513_+_B2_Mm2
NM_008997 734 923 -3 + B2_Mm2 SINE/B2 1 186 -9 >AK133808_734_923_+_B2_Mm2
NM_080555 286 382 -4 + B2_Mm1t SINE/B2 75 171 -22 >AK134674_286_382_+_B2_Mm1t
NM_010332 2428 2606 -1 + B2_Mm2 SINE/B2 1 183 -12 >AK135599_2428_2606_+_B2_Mm2
NM_172467 2948 3108 -3 + B2_Mm2 SINE/B2 1 162 -33 >AK137583_2948_3108_+_B2_Mm2
NM_175115 81 274 -2006 + B2_Mm2 SINE/B2 2 195 0 >AK138675_81_274_+_B2_Mm2
NM_010071 3150 3339 -54 + B2_Mm2 SINE/B2 1 195 0 >AK155102_3150_3339_+_B2_Mm2
NM 183014 288 442 -20 + B3A SINE/B2 48 198 0 >AK015655_288_442_+_B3A
NM_026555 277 435 -24 + B3A SINE/B2 40 198 0 >AK021299_277_435_+_B3A
NM_033077 1109 1295 -1732 + B3A SINE/B2 5 189 -9 >AK029689_1109_1295_+_B3A
NM_019789 1052 1211 -1195 + B3 SINE/B2 33 196 -20 >AK030353_1052_1211_+_B3
NM_178891 2403 2558 -3 + B3 SINE/B2 20 176 -40 >AK030551_2403_2558_+_B3
NM_145579 2546 2719 -346 + B3 SINE/B2 2 206 -10 >AK031007 2546 2719_+_B3
NM_008510 2255 2404 -429 + B3A SINE/B2 57 198 0 >AK034030 2255 2404_+_B3A
NM_153579 1071 1262 -798 + B3 SINE/B2 1 214 -2 >AK035406_1071_1262_+_B3
NM_145942 1006 1219 -681 + B3 SINE/B2 2 216 0 >AK037188_1006_1219_+_B3
NM_025788 1871 2045 -757 + B3 SINE/B2 1 215 -1 >AK039409_1871_2045_+_B3
NM_008019 877 1044 -1057 + B3 SINE/B2 2 211 -5 >AK040162_877_1044_+_B3
NM_001081475 1431 1582 -6 + B3 SINE/B2 69 216 0 >AK040401_1431_1582_+_B3
NM_001081475 1586 1745 -2 + B3 SINE/B2 3 206 -10 >AK040401_1586_1745_+_B3
NM_007485 722 810 -519 + B3 SINE/B2 1 89 -127 >AK044205_722_810_+_B3
NM_007485 835 912 -417 + B3 SINE/B2 138 215 -1 >AK044205_835_912_+_B3
NM_178794 826 959 -986 + B3A SINE/B2 2 129 -69 >AK045196_826_959_+_B3A
NM_008915 737 940 -298 + B3 SINE/B2 8 201 -15 >AK046652_737_940_+_B3
NM_010633 971 1096 -135 + B3 SINE/B2 1 129 -87 >AK047213_971_1096_+_B3
NM_199476 3267 3405 -1039 + B3 SINE/B2 2 149 -67 >AK047540_3267_3405_+_B3
NM_144795 2052 2248 -546 + B3 SINE/B2 2 210 -6 >AK048854_2052_2248_+_B3
#N/A 1858 2028 -5 + B3A SINE/B2 1 176 -22 >AK049524_1858_2028_+_B3A
NM_001038621 1207 1363 -359 + B3A SINE/B2 2 160 -38 >AK053130_1207_1363_+_B3A
NM_181423 1666 1733 -71 + B3A SINE/B2 2 72 -126 >AK054359_1666_1733_+_B3A
NM_153515 1403 1520 -470 + B3A SINE/B2 63 183 -15 >AK078013_1403_1520_+_B3A
NM_ 98415 403 623 -1212 + B3 SINE/B2 1 216 0 >AK078328_403_623_+_B3
NM_152220 1794 1979 -561 + B3 SINE/B2 3 213 -3 >AK078537_1794_1979_+_B3
NM_025729 1 165 -203 + B3 SINE/B2 15 177 -39 >AK079403_1_165_+_B3
NM_016693 1307 1517 -13 + B3 SINE/B2 2 216 0 >AK080235_1307_1517_+_B3
NM_010151 814 1024 -451 + B3 SINE/B2 2 216 0 >AK082108_814_1024_+_B3
NM_009713 1690 1882 -5 + B3 SINE/B2 1 199 -17 >AK082325_1690_1882_+_B3
NM_001029985 221 280 -1179 + B3 SINE/B2 108 168 -48 >AK084376_221_280_+_B3
NM_ 009737 1805 2005 -406 + B3 SINE/B2 1 207 -9 >AK085337_1805_2005_+_B3
NM_ 027081 984 1130 -1155 + B3 SINE/B2 1 162 -54 >AK086470_984_1130_+_B3
NM_018779 876 1062 -530 + B3A SINE/B2 2 188 -10 >AK089148_876_1062_+_B3A
NM_027919 1468 1667 -185 + B3 SINE/B2 1 213 -3 >AK090182_1468_1667_+_B3
NM_011034 434 608 -12 + B3 SINE/B2 2 216 0 >AK131819_434_608_+_B3
NM_175551 1802 1895 -513 + B3A SINE/B2 64 176 -22 >AK132737_1802_1895_+_B3A
NM_175551 1829 1928 -480 + B3 SINE/B2 101 213 -3 >AK132737_1829_1928_+_B3
NM_007921 951 1134 -1650 + B3A SINE/B2 3 187 -11 >AK133325_951_1134_+_B3A
NM_001039042 1220 1315 -292 + B3A SINE/B2 48 142 -56 >AK134755_1220_1315_+_B3A
NM_177328 1378 1504 -285 + B3 SINE/B2 85 216 0 >AK134874_1378_1504_+_B3
NM_021899 1172 1259 -140 + B3 SINE/B2 1 95 -121 >AK135206_1172_1259_+_B3
NM_008705 1521 1717 -572 + B3A SINE/B2 1 197 -1 >AK136279_1521_1717_+_B3A
NM_001079932 2116 2299 -702 + B3 SINE/B2 6 208 -8 >AK137643_2116_2299_+_B3
NM_001079932 3059 3253 -2 + B3 SINE/B2 4 205 -11 >AK137643_3059_3253_+_B3
NM_001033286 2524 2698 -63 + B3A SINE/B2 4 181 -17 >AK138296_2524_2698_+_B3A
NM_008962 928 1095 -375 + B3 SINE/B2 1 153 -63 >AK138521_928_1095_+_B3
NM_175349 2151 2347 -181 + B3A SINE/B2 11 196 -2 >AK139254_2151_2347_+_B3A
NM_177003 1277 1466 0 + B3 SINE/B2 1 200 -16 >AK139647_1277_1466_+_B3
NM_007965 1338 1488 -5 + B3 SINE/B2 51 216 0 >AK140072_1338_1488_+_B3
NM_010192 1808 1933 -45 + B3 SINE/B2 1 126 -90 >AK140346_1808_1933_+_B3
NM_027446 1871 1983 -2794 + B3A SINE/B2 1 130 -68 >AK140616_1871_1983_+_B3A
NM_027446 2318 2342 -2435 + B3A SINE/B2 131 156 -42 >AK140616_2318_2342_+_B3A
NM_177186 2061 2142 -351 + B3 SINE/B2 130 211 -5 >AK142359_2061_2142_+_B3
NM_145134 2963 3148 -1292 + B3 SINE/B2 28 210 -6 >AK142507_2963_3148_+_B3
NM_009890 2740 2968 -135 + B3 SINE/B2 1 216 0 >AK142879_2740_2968_+_B3
NM_146055 5202 5272 -94 + B3 SINE/B2 60 141 -75 >AK143143_5202_5272_+_B3
NM_008977 1344 1513 -645 + B3 SINE/B2 11 205 -11 >AK143279_1344_1513_+_B3
NM_026036 2001 2167 -272 + B3A SINE/B2 1 169 -29 >AK149843_2001_2167_+_B3A
NM_001159519 1440 1548 -1422 + B3A SINE/B2 55 163 -35 >AK157402_1440_1548_+_B3A
NM_001159519 2503 2556 -558 + B3 SINE/B2 1 56 -160 >AK157402_2503_2556_+_B3
NM_001159519 2544 2616 -498 + B3 SINE/B2 109 177 -39 >AK157402_2544_2616_+_B3
NM_001159519 2702 2896 -412 + B3A SINE/B2 1 198 0 >AK157402_2702_2896_+_B3A
NM_001110504 1778 1909 -25 + B3 SINE/B2 58 210 -6 >AK160921_1778_1909_+_B3
NM_030714 2153 2335 -62 + B3 SINE/B2 40 216 0 >AK165234_2153_2335_+_B3
NM_025825 945 1052 -383 RC B2_Mm1a SINE/B2 -85 108 1 >AK014613_945_1052_RC_B2_Mm1a
NM_133756 1102 1289 -246 RC B2_Mm2 SINE/B2 -4 191 1 >AK016234_1102_1289_RC_B2_Mm2
NM_183294 1565 1750 -1384 RC B2_Mm1a SINE/B2 -8 185 4 >AK029702_1565_1750_RC_B2_Mm1a
NM_009446 531 710 -2730 RC B2_Mm 2 SINE/B2 -6 189 2 >AK030803_531_710_RC_B2_Mm2
NM_025788 1687 1839 -963 RC B2_Mm2 SINE/B2 -11 184 1 >AK039409_1687_1839_RC_B2_Mm2
NM_177785 1626 1682 -1130 RC B2_Mm2 SINE/B2 -4 191 137 >AK040275_1626_1682_RC_B2_Mm2
NM_177785 1682 1739 -1073 RC B2_Mm2 SINE/B2 -94 101 46 >AK040275_1682_1739_RC_B2_Mm2
NM_177785 1776 1952 -1036 RC B2_Mm1t SINE/B2 -13 180 2 >AK040275_1776_1952_RC_B2_Mm1t
NM_007485 1137 1341 -192 RC B2_Mm2 SINE/B2 0 195 2 >AK044205_1137_1341_RC_B2_Mm2
NM_175273 537 714 -1793 RC B2_Mm2 SINE/B2 -5 190 1 >AK048762_537_714_RC_B2_Mm2
NM_029409 1005 1172 -2204 RC B2_Mm1t SINE/B2 -14 179 1 >AK049449_1005_1172_RC_B2_Mm1t
NM_007836 282 407 -2067 RC B2_Mm2 SINE/B2 -67 128 2 >AK054076_282_407_RC_B2_Mm2
NM 007836 1764 1860 -614 RC B2_Mm2 SINE/B2 -97 98 2 >AK054076_1764_1860_RC_B2_Mm2
NR_002891 1 181 -2344 RC B2_Mm1a SINE/B2 -10 183 2 >AK076350_1_181_RC_B2_Mm1a
NM_026500 984 1157 -1501 RC B2_Mm2 SINE/B2 -14 181 1 >AK076438_984_1157_RC_B2_Mm2
NM_052994 2158 2323 -1225 RC B2_Mm2 SINE/B2 -4 191 8 >AK079094_2158_2323_RC_B2_Mm2
NM_153100 1870 2057 -1774 RC B2_Mm2 SINE/B2 0 195 1 >AK086953_1870_2057_RC_B2_Mm2
NM_175313 2088 2261 -2958 RC B2_Mm2 SINE/B2 -9 186 14 >AK132441_2088_2261_RC_B2_Mm2
NM_001114140 5305 5461 -1145 RC B2_Mm2 SINE/B2 -38 157 2 >AK133162_5305_5461_RC_B2_Mm2
NM_009579 1059 1251 -2941 RC B2_Mm2 SINE/B2 0 195 1 >AK137370_1059_1251_RC_B2_Mm2
NM_010567 1613 1794 -1882 RC B2_Mm2 SINE/B2 -2 193 1 >AK138181_1613_1794_RC_B2_Mm2
NM_001008423 2088 2222 -57 RC B2_Mm2 SINE/B2 -60 135 1 >AK141165_2088_2222_RC_B2_Mm2
NM_199027 935 1064 -63 RC B2_Mm2 SINE/B2 -65 130 1 >AK141411_935_1064_RC_B2_Mm2
NM_001033316 3103 3283 -440 RC B2_Mm2 SINE/B2 -5 190 2 >AK145736_3103_3283_RC_B2_Mm2
NR_003492 748 810 -977 RC B2_Mm1a SINE/B2 -6 187 123 >AK147092_748_810_RC_B2_Mm1a
NM_010567 935 1129 -78 RC B2_Mm2 SINE/B2 0 195 2 >AK148373_935_1129_RC_B2_Mm2
NM_026115 3593 3791 -204 RC B2_Mm2 SINE/B2 -1 194 1 >AK155374_3593_3791_RC_B2_Mm2
NM_010398 1080 1265 -909 RC B2_Mm2 SINE/B2 -8 187 1 >AK157261_1080_1265_RC_B2_Mm2
NM_007893 764 820 -1012 RC B2_Mm2 SINE/B2 -94 101 47 >AK163105_764_820_RC_B2_Mm2
NM_007893 894 1062 -938 RC B2_Mm2 SINE/B2 -13 182 1 >AK163105_894_1062_RC_B2_Mm2
NM_007893 1390 1436 -564 RC B2_Mm2 SINE/B2 -5 190 137 >AK163105_1390_1436_RC_B2_Mm2
NM_007893 1436 1490 -510 RC B2_Mm2 SINE/B2 -94 101 47 >AK163105_1436_1490_RC_B2_Mm2
NM_007893 1543 1701 -299 RC B2_Mm1t SINE/B2 -24 169 1 >AK163105_1543_1701_RC_B2_Mm1t
NM_177186 1783 1964 -258 RC B2_Mm1t SINE/B2 -7 186 2 >AK163831_1783_1964_RC_B2_Mm1t
NM_030714 1401 1588 -809 RC B2_Mm2 SINE/B2 0 195 3 >AK165234_1401_1588_RC_B2_Mm2
NM_001110101 1253 1420 -1139 RC B2_Mm2 SINE/B2 -22 173 2 >AK169421_1253_1420_RC_B2_Mm2
NM_007601 387 544 -1715 RC B3A SINE/B2 -22 176 1 >AK016423_387_544_RC_B3A
NM_027346 1459 1690 -74 RC B3 SINE/B2 -2 214 1 >AK019925_1459_1690_RC_B3
NM_138664 1382 1411 -1334 RC B3A SINE/B2 -148 50 21 >AK028982_1382_1411_RC_B3A
NM_013840 160 290 -556 RC B3 SINE/B2 -79 137 9 >AK029359_160_290_RC_B3
NM_013840 774 960 -72 RC B3 SINE/B2 -7 209 1 >AK029359_774_960_RC_B3
NM_153591 769 982 -1569 RC B3 SINE/B2 -6 210 1 >AK032194_769_982_RC_B3
NM_028794 1926 2130 -654 RC B3 SINE/B2 -12 204 2 >AK032215_1926_2130_RC_B3
NM_001012311 1317 1437 -1013 RC B3 SINE/B2 -44 172 38 >AK034331_1317_1437_RC_B3
NM_001012311 1335 1437 -1013 RC B3A SINE/B2 -54 144 38 >AK034331_1335_1437_RC_B3A
NM_134122 1094 1205 -719 RC B3 SINE/B2 -88 128 1 >AK035015_1094_1205_RC_B3
NM_153579 1443 1617 -577 RC B3 SINE/B2 -2 214 45 >AK035406_1443_1617_RC_B3
NM_153579 1483 1633 -561 RC B3A SINE/B2 -18 180 27 >AK035406_1483_1633_RC_B3A
NM_001081014 1615 1715 -218 RC B3A SINE/B2 -88 110 1 >AK039704_1615_1715_RC_B3A
NM_018747 432 531 -1672 RC B3A SINE/B2 -31 167 49 >AK040672_432_531_RC_B3A
NM_176841 1677 1886 -64 RC B3 SINE/B2 0 216 2 >AK041236_1677_1886_RC_B3
NM_133878 1676 1882 -314 RC B3 SINE/B2 -7 209 1 >AK041654_1676_1882_RC_B3
NM_145215 2334 2533 -484 RC B3 SINE/B2 0 216 3 >AK041742_2334_2533_RC_B3
NM_145369 1132 1336 -593 RC B3 SINE/B2 -7 209 5 >AK042861_1132_1336_RC_B3
NM_172691 248 442 -151 RC B3A SINE/B2 -18 180 10 >AK043958_248_442_RC_B3A
NM_007485 938 1127 -202 RC B3 SINE/B2 -37 179 2 >AK044205_938_1127_RC_B3
NM_007485 989 1127 -202 RC B3A SINE/B2 -57 141 2 >AK044205_989_1127_RC_B3A
NM_007925 592 713 -719 RC B3 SINE/B2 -54 162 39 >AK045677_592_713_RC_B3
NM_177006 3566 3620 -1104 RC B3 SINE/B2 -160 56 2 >AK046828_3566_3620_RC_B3
NM_010633 431 640 -591 RC B3 SINE/B2 -4 212 8 >AK047213_431_640_RC_B3
NM_010633 457 640 -591 RC B3A SINE/B2 -7 191 8 >AK047213_457_640_RC_B3A
NM_008842 1460 1636 -53 RC B3A SINE/B2 -4 194 10 >AK047301_1460_1636_RC_B3A
NM_199476 2716 2780 -1664 RC B3A SINE/B2 -36 162 98 >AK047540_2716_2780_RC_B3A
NM_013514 1203 1416 -311 RC B3 SINE/B2 0 216 1 >AK048309_1203_1416_RC_B3
NM_080793 2342 2396 -1333 RC B3A SINE/B2 -5 193 144 >AK048747_2342_2396_RC_B3A
NM_080793 2430 2530 -1199 RC B3A SINE/B2 -55 143 47 >AK048747_2430_2530_RC_B3A
NM_001038621 159 275 -1447 RC B3 SINE/B2 -56 160 34 >AK053130_159_275_RC_B3
NM_007836 1747 1860 -614 RC B3 SINE/B2 -97 119 2 >AK054076_1747_1860_RC_B3
NM_010878 1134 1337 -1192 RC B3 SINE/B2 0 216 1 >AK078161_1134_1337_RC_B3
NM_011670 521 690 -995 RC B3 SINE/B2 -60 156 1 >AK078321_521_690_RC_B3
NM_026086 882 1046 -355 RC B3A SINE/B2 -18 180 1 >AK079515_882_1046_RC_B3A
NM_025396 1081 1179 -370 RC B3 SINE/B2 -27 189 75 >AK080749_1081_1179_RC_B3
NM_007923 2420 2567 -582 RC B3A SINE/B2 -48 150 4 >AK086589_2420_2567_RC_B3A
NM_028427 1420 1597 -495 RC B3 SINE/B2 -5 211 2 >AK090347_1420_1597_RC_B3
NM_026157 1871 2066 -1227 RC B3A SINE/B2 0 198 5 >AK132393_1871_2066_RC_B3A
NM_026157 2342 2408 -885 RC B3A SINE/B2 -131 67 1 >AK132393_2342_2408_RC_B3A
NM_026157 2473 2606 -687 RC B3A SINE/B2 -25 173 28 >AK132393_2473_2606_RC_B3A
NM_175313 2113 2261 -2958 RC B3 SINE/B2 -40 176 14 >AK132441_2113_2261_RC_B3
NM_175313 4127 4308 -948 RC B3 SINE/B2 -6 210 28 >AK132441_4127_4308_RC_B3
NM_024282 1137 1290 -91 RC B3A SINE/B2 -39 159 1 >AK132990_1137_1290_RC_B3A
NM_177328 277 358 -1283 RC B3A SINE/B2 -56 142 66 >AK134874_277_358_RC_B3A
NM_177328 405 484 -1157 RC B3A SINE/B2 -133 65 1 >AK134874_405_484_RC_B3A
NM_177328 545 713 -928 RC B3A SINE/B2 -4 194 14 >AK134874_545_713_RC_B3A
NM_177328 787 971 -670 RC B3A SINE/B2 -4 194 7 >AK134874_787_971_RC_B3A
NM_021899 161 307 -1092 RC B3A SINE/B2 -46 152 1 >AK135206_161_307_RC_B3A
NM_010332 228 409 -1967 RC B3 SINE/B2 -28 188 2 >AK135599_228_409_RC_B3
NM_172407 1470 1683 -74 RC B3 SINE/B2 -5 211 2 >AK143014_1470_1683_RC_B3
NM_001009935 1389 1495 -157 RC B3 SINE/B2 -96 120 1 >AK143784_1389_1495_RC_B3
NM_019827 2953 3143 -1064 RC B3 SINE/B2 -1 215 1 >AK145079_2953_3143_RC_B3
NM_011212 2131 2283 -1263 RC B3A SINE/B2 -47 151 2 >AK148045_2131_2283_RC_B3A
NM_010567 984 1129 -78 RC B3A SINE/B2 -60 138 2 >AK148373_984_1129_RC_B3A
NM_001110504 1406 1594 -400 RC B3A SINE/B2 -10 188 2 >AK149403_1406_1594_RC_B3A
NM_026036 2270 2439 0 RC B3 SINE/B2 -4 212 27 >AK149843_2270_2439_RC_B3
NM_010398 1292 1476 -698 RC B3A SINE/B2 -11 187 3 >AK157261_1292_1476_RC_B3A
NM_001110504 1292 1362 -572 RC B3A SINE/B2 -112 86 11 >AK160921_1292_1362_RC_B3A
NM_007893 1080 1254 -746 RC B3 SINE/B2 0 216 21 >AK163105_1080_1254_RC_B3
NM_007893 1427 1491 -509 RC B3A SINE/B2 -82 116 46 >AK163105_1427_1491_RC_B3A
NM_030714 1954 2064 -333 RC B3 SINE/B2 -95 121 2 >AK165234_1954_2064_RC_B3
NM_001110101 853 1043 -1516 RC B3 SINE/B2 -5 211 6 >AK169421_853_1043_RC_B3
NM_001110101 1742 1936 -623 RC B3 SINE/B2 -2 214 8 >AK169421_1742_1936_RC_B3
; or

(5) an RNA (i) which is at least 95% similar to the RNA of (1), (2). (3) or (4) and has a function of increasing the protein synthesis efficiency.


  7. A DNA molecule encoding a trans-acting functional nucleic acid molecule according to any one of claims 1 to 5.
  8. An expression vector comprising a trans-acting functional nucleic acid molecule according to any one of claims 1 to 5, or a DNA molecule according to claim 7.
  9. A composition for increasing protein synthesis efficiency, which comprises a trans-acting functional nucleic acid molecule according to any one of claims 1 to 5, a DNA molecule according to claim 7, or an expression vector according to claim 8.
  10. A method for increasing the protein synthesis efficiency, comprising the step of (a) allowing a trans-acting functional nucleic acid molecule according to any one of claims 1 to 5 to coexist with a protein-encoding RNA, which partial sequence of the protein-encoding RNA has similarity with the target determinant sequence of the functional RNA molecule.
  11. The method according to claim 10, wherein the step (a) comprises transfecting into a cell the trans-acting functional nucleic acid molecule or a DNA molecule according to claim 7.
  12. A method for producing a protein, comprising the step of increasing the protein synthesis efficiency by a method for increasing the protein synthesis efficiency according to claim 10 or claim 11.