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1. WO1992016168 - SURFACE-MODIFIED SELF-PASSIVATING INTRAOCULAR LENSES

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. An intraocular lens, comprising an optic bearing a coating comprising c 12^36 a*Ucy1 groups, whereby said optic exhibits enhanced ability to adsorb and retain albumin.

2. An intraocular lens according to Claim 1, which further comprises one or more haptics attached to said optic for use in securing or positioning said optic in an eye of a patient.

3. An intraocular lens according to Claim 2, wherein said one or more haptics also bear a coating comprising C12-C3 alkyl groups to thereby enhance the ability of said one or more haptics to adsorb and retain albumin.

4. An intraocular lens according to Claim 1, wherein said optic comprises poly(methyl methacrylate).

5. An intraocular lens according to Claim 1, wherein said coating comprises a mixture of monomeric, oligomeric, or polymeric Cj^-Cβg * methacrylates.

6. An intraocular lens according to Claim 5, wherein said alkyl methacrylate is lauryl or octadecyl methacrylate or a mixture thereof.

7. An intraocular lens according to Claim 5, wherein said alkyl methacrylate is polymerized.

8. An intraocular lens according to Claim 7, wherein said polymerized alkyl methacrylate is a copolymer of a C12~C3 alkyl methacrylate and methyl methacrylate.

9. An intraocular lens according to Claim 1, wherein said intraocular lens comprises an optic made of poly (methyl methacrylate) coated with one or a mixture of monomeric, oligomeric, or polymeric C12-C3 alkyl methacrylates.

10. An intraocular lens according to Claim 9, wherein said one or a mixture of C12-C36 methacrylates are coated on said optic by centrifugal spin casting.

11. An intraocular lens according to Claim 9, wherein said one or a mixture of C12-C alkyl methacrylates are coated on said optic by a plasma deposition technique in a deposition chamber, wherein a temperature differential is created between the optic and said deposition chamber sufficient to cause a C}2~C3 alkyl methacrylate monomer to preferentially condense or adsorb and then polymerize on said optic, thereby resulting in a coating on said optic that enhances adsorption and retention of albumin thereon.

12. A method of enhancing biocompatability of an intraocular lens comprising an optic, which method comprises applying to said optic a coating comprising C12-C3g alkyl groups, whereby said optic exhibits enhanced ability to adsorb and retain albumin.

13. A method according to Claim 12, wherein said coating comprises a C12"C36 a-* *- mβthacrylate monomer, oligomer, or polymer.

14. A method according to Claim 12, wherein said coating is applied by spin casting a polymeric C12-C36 alkyl methacrylate on said optic.

15. A method according to Claim 12, wherein said coating is applied by plasma deposition of C12-C3g alkyl methacrylate monomers on the surface of said optic, under conditions whereby the alkyl groups are substantially unfragmented.

16. A method according to Claim 15, wherein said plasma deposition is carried out in a deposition chamber wherein there is a temperature differential between said optic and said deposition chamber sufficient to cause said monomers to preferentially condense or adsorb and then to polymerize on said optic, thereby resulting in a coating on said optic that enhances adsorption and retention of albumin on said optic.

17. A method according to Claim 12, wherein said optic comprises poly (methyl methacrylate).

18. A method according to Claim 12, wherein said intraocular lens further comprises one or more haptics attached to said optic for use in securing or positioning said optic in an eye of a patient.

19. A method according to Claim 18, wherein said one or more haptics also bear a coating comprising C12-C3 alkyl groups.