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1. WO1992016168 - SURFACE-MODIFIED SELF-PASSIVATING INTRAOCULAR LENSES

Publication Number WO/1992/016168
Publication Date 01.10.1992
International Application No. PCT/US1992/002310
International Filing Date 20.03.1992
Chapter 2 Demand Filed 14.10.1992
IPC
A61L 27/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
34Macromolecular materials
CPC
A61F 2/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
14Eye parts, e.g. lenses, corneal implants; ; Implanting instruments specially adapted therefor; Artificial eyes
16Intraocular lenses
A61L 2430/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
16for reconstruction of eye parts, e.g. intraocular lens, cornea
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
34Macromolecular materials
B05D 1/62
BPERFORMING OPERATIONS; TRANSPORTING
05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
1Processes for applying liquids or other fluent materials
62Plasma-deposition of organic layers
C08J 7/123
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
7Chemical treatment or coating of shaped articles made of macromolecular substances
12Chemical modification
123Treatment by wave energy or particle radiation
Applicants
  • THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON [US]/[US]
Inventors
  • RATNER, Buddy, D.
  • TIDWELL, Caren, L.
Agents
  • SHELTON, Dennis, K.
Priority Data
675,60025.03.1991US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SURFACE-MODIFIED SELF-PASSIVATING INTRAOCULAR LENSES
(FR) LENTILLES INTRAOCULAIRES AUTOPASSIVANTES A SURFACE MODIFIEE
Abstract
(EN)
Intraocular lenses are coated with C12-C36 alkyl groups that render the surface of the intraocular lens less prone to causing inflammation after implantation of the intraocular lens. The alkyl groups may be coated on the IOL by a centrifugal casting method, a solution deposition method (e.g., a covalent attachment method), or a plasma deposition method that minimizes fragmentation of the alkyl groups. A preferred IOL includes an optic (2) and haptics (4). The optics (2) and haptics (4) of the present invention may be made of any material that is standard in the art of IOLs, or others developed in the future for this purpose. It is also possible to employ IOLs that do not have haptics (4), and which are supported in the eye by any suitable means. When a haptic (4) is present, either or both of the optic (2) and the haptic(s) (4) may be coated by alkyl groups.
(FR)
La présente invention se rapporte à des lentilles intraoculaires revêtues de groupes alkyle C12-C36 qui rendent leurs surfaces moins susceptibles de provoquer une inflammation après leur implantation. Les lentilles intraoculaires peuvent être revêtues de groupes alkyle par un procédé centrifuge, par dépôt sous forme de solution (par exemple, un procédé de liaison covalente), ou par dépôt sous forme de plasma qui minimise la fragmentation des groupes alkyle. Une lentille intraoculaire préférée comprend un élément optique (2) et un élément haptique (4). Lesdits éléments optique (2) et haptique (4) peuvent se composer de toute matière utilisée couramment dans la production de lentilles intraoculaires, ou d'autres matières qui seront développées dans le futur à cet effet. Il est également possible d'utiliser des lentilles intraoculaires dépourvues d'éléments haptiques (4), et qui sont maintenues dans l'÷il par tout moyen approprié. Lorsqu'un élément haptique (4) est présent, l'élément optique (2) et/ou l'élément haptique (4) peuvent être revêtus par des groupes alkyle.
Also published as
Latest bibliographic data on file with the International Bureau