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1. WO2010096314 - INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

What is Claimed:

1. A compound of Formula (I):


where: Z1 is -N- or -CH-;

X is -NR6- or -O- where R6 is hydrogen or alkyl;

R1 is aryl, heteroaryl, cycloalkyl, fused cycloalkenyl, or heterocyclyl; each ring substituted with Ra, Rb, or Rc independently selected from hydrogen, alkyl, alkylthio, alkoxy, hydroxy, alkoxycarbonyl, carboxy, halo, haloalkyl, haloalkoxy, aminocarbonyl, aminosulfonyl, cycloalkyl, cycloalkylalkyl, acyl, cyano, aminoalkyl, hydroxyalkyl, optionally substituted heteroaryl, optionally substituted phenyl, amino, ureido, thioureido, monosubstituted, or disubstituted amino;

R2 is:

(i) ^ x•^r ^ Z ^ — CH 3 w]jere Y an(j 2 are independently -N= or -C=; or (ii) a five or six membered heterocyclyl ring; each ring in (i) and (ii) is substituted with Rd and Re where Rd and Re are independently hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, amino, monosubstituted amino or disubstituted amino;

R3 and R4 are independently hydrogen, alkyl, halo, alkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyano, carboxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclyl, aralkyl, heteroaralkyl, heterocyclylalkyl, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, hydroxyalkyloxy, alkoxyalkyloxy, aminoalkyl, aminoalkoxy, aryloxy, heteroaryloxy, heterocyclyloxy, aralkoxy, heteroaralkoxy, heterocyclylalkyloxy, aminosulfonyl, aminocarbonyl, or acylamino, where the aromatic or alicyclic ring in R3 and R4 is optionally substituted with Rf, Rg or Rh which are independently selected from alkyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, or acylamino; and R5 is hydrogen, alkyl, halo, hydroxyl, alkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyano, carboxy, alkoxycarbonyl, amino, alkylamino, or dialkylamino; or a pharmaceutically acceptable salt thereof; provided that:

(i) when Z1 is -N=, R2 is piperidin-4-yl, 4-methylpiperidin-l-yl, or 1-methylpiperidin-4-yl; X is -NH-, R3 is hydrogen, and R1 is phenyl substituted at the 4-position with ethyl or -COR where R is methylamino, methoxy, methyl, or amino; 3,4,5-trimethyloxyphenyl, or 3,5-dimethoxyphenyl, then R4 is not -CON(CH2CH2CH(CH3)2)2; or -CON(i-Bu)2;

(ii) when Z1 is -N=, R2 is 6-chloro-5-methylpyrimidin-4-yl, 5-methyl-6-[4-diethylaminobutylamino]-pyrimidin-4-yl, or 6-amino-5-methylpyrimidin-4-yl, X is -NH-, R and R4 are hydrogen, then R1 is not 6-methyl-3-(3-trifluoromethylphenylcarbonylamino)phenyl; and

(iii) when Z1 is -N=, R2 is tetrahydropyran-2-yl, X is -NH-, R3 and R4 are hydrogen, then R1 is not piperidin-4-yl or l-ethoxycarbonylpiperidin-4-yl; and

(iv) the compound is not l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-3-pyrrolidinyl-1 H-benzimidazole-2-amine and 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-imidazol-2-yl-1 H-benzimidazole-2-amine.

2. The compound of Claim 1 wherein Z1 is -N- and X is -NR6-.

3. The compound of Claim 1 wherein Z1 is -N- and X is -NH-.

4. The compound of Claim 1 wherein Z1 is -N- and X is -O-.

5. The compound of any of the Claims 1-4 wherein R1 is phenyl substituted with Ra, Rb, or Rc

6. The compound of any of the Claims 1-4 wherein R1 is heteroaryl substituted Ra, Rb, or Rc .

7. The compound of any of the Claims 1-4 wherein R1 is pyrazolyl substituted Ra, Rb, or Rc . 8. The compound of any of the Claims 1-4 wherein R1 is phenyl substituted with Ra, Rb or Rc where Ra is hydrogen, Rb is hydrogen or hydroxy, and Rc is hydrogen, cyano, acyl, ureido, thioureido, alkoxycarbonyl, alkoxy, hydroxy, amino, cycloalkyl, carboxy, halo, aminocarbonyl, aminisulfonyl, alkyl, or monosubstituted amino (-NRR' where R is hydrogen and R' is hydrogen acyl, or sulfonyl) and R3, R4 and R5 are hydrogen. 9. The compound of any of the Claims 1-4 wherein R1 is 3,5-dihydroxyphenyl; 3-(-NHCONHCH3)phenyl; 3-(-NHCONHCH2CH3)-phenyl; 3-(3-hydroxyphenyl-NHCONH-)phenyl; 3 -hydroxy-5 -methoxy carbonyl-phenyl; 3-hydroxy-4-methoxyphenyl; 3-(3-methoxyphenyl-NHCONH-)phenyl; 3-(4-methoxycarbonylphenyl-NHCONH-)phenyl; 4-carboxy-2-hydroxyphenyl; 4-hydroxyphenyl; 3-carboxyphenyl; 4-fluoro-3-hydroxyphenyl; 3- methoxyphenyl; 3-CONH2phenyl; 3-hydroxy-4-methylphenyl; 4-(4-fiuorophenylsulfonyl)-aminophenyl; 4-(4-methylphenylsulfonyl)-aminophenyl; 3-SO2NH2phenyl; phenyl; A-methylsulfonylaminopheny 1; 3 -hydroxy-4-methoxycarbonylphenyl; A-ethylcarbonylaminophenyl; 3-methylphenyl; 3-chlorophenyl; 3 -fluorophenyl; 3-cyanophenyl; 4-acetylaminophenyl; 3-hydroxyphenyl; 3-methoxycarbonylphenyl; 3-hydroxy-4-acetylphenyl; 4-[4-methoxyphenylNHCSNH-]phenyl; 4-[3-methoxyphenylNHCSNH-]phenyl; 2,6-dichlorophenylsulfonyl-aminophenyl; 4-[ethylNHCSNH-]phenyl; 3-[3,5-dichlorophenyl-NHCSNH-]phenyl; 4-[2-trifluoromethylphenyl-sulfonylamino]]phenyl; 4-[-NHCONHCH3]-phenyl; 4-[-NHCONHCH2CH3]phenyl; 4-[-NHCONHpyridin-4-yl]phenyl; 4-methylcarbonyl-aminophenyl; 4-cyclopropylcarbonylamino-phenyl; 3-F-4-hydroxyphenyl; 4-(ethylamino-carbonyl)phenyl; 4-(pyridin-4-ylaminocarbonyl)-phenyl; 3-methylcarbonylamino-phenyl; A-(2,3-dihydro- 1 -benzofuran-5-ylcarbonylamino)phenyl; 4-aminophenyl; 4-(3-dimethylamino-phenyl-carbonylamino)phenyl; 4-(cyclopentylcarbonylamino)-phenyl; 4-(tert-butylcarbonylamino)-phenyl; 4-(2.1.3-benzothiadiazol-4-ylcarbonylamino)phenyl; 4-(2-isopropylaminocarbonyl)-phenyl; 4-(3,5-diClphenylNHCSNH-)phenyl; 4-(4-tert-butylphenylcarbonyl-amino)phenyl; 4-(cyclohexylcarbonyl-amino)phenyl; 4-(3 -CF3phenylcarbonyl-amino)phenyl; 4-(4-OCF3phenylcarbonyl-amino)phenyl; or 4-(4-fluorophenylsulfonyl-amino)phenyl.

10. The compound of any of the Claims 1-4 wherein R1 is heteroaryl substituted with Ra, Rb or Rc where Ra and Rb are hydrogen, and Rc is hydrogen, cyano, acyl, ureido, thioureido, alkoxycarbonyl, alkoxy, hydroxy, amino, cycloalkyl, cycloalkylalkyl, optionally substituted heteroaryl, carboxy, halo, aminocarbonyl, alkyl, haloalkyl, or monosubstituted amino (-NRR' where R is hydrogen and R' is hydrogen acyl, or sulfonyl) and R3, R4 and R5 are hydrogen.

11. The compound of any of the Claims 1-4 wherein R1 is heteroaryl substituted with Ra, Rb or Rc where Ra and Rb are hydrogen, and Rc is hydrogen, cyano, acyl, alkoxycarbonyl, alkoxy, hydroxy, amino, cycloalkyl, cycloalkylalkyl, optionally substituted heteroaryl, halo, aminocarbonyl, alkyl, or haloalkyl and R3, R4 and R5 are hydrogen.

12. The compound of any of the Claims 1-11 wherein R2 is

^ Z 3 where Y and 2 are independently -N= or -C= and is substituted with R where Rd is hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, amino, monosubstituted amino or disubstituted amino and Re is hydrogen.

13. The compound of Claim 1-11 wherein wherein R2 is I^ ^J Q|_j

"^ Z ~- 3 where Z is -N= and is substituted with R where R is hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, amino, monosubstituted amino or disubstituted amino and Re is hydrogen.

14. The compound of Claim 1-11 wherein wherein R2 is


2 are -N= and is substituted with R where R is hydrogen, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, amino, monosubstituted amino or disubstituted amino and Re is hydrogen.

15. The compound of Claim 1-11 wherein wherein R2 is

Y^N

,< *■* ^ — CH x^ Z 3 where Y and Z are -N= and is substituted with R where R is monosubstituted amino and is at the 4-position of the triazin-2-yl ring and Re is hydrogen.

16. The compound of Claim 1-11 wherein R2 is 4-amino-6-methyl-l,3,5-triazin-2-yl.

17. The compound of Claim 1 selected from:

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)- 1,3-benzenediol; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-2-((3 -hydroxyphenyl)amino)- 1 H-benzimidazole-6-carboxylic acid;

3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenol; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-methylurea; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-ethylurea;

((4-(2-((3-hydroxyphenyl)amino)-lH-benzimidazol-l-yl)-6-methyl-l,3,5-triazin-2-yl)-amino)acetonitrile ; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(3-hydroxyphenyl)urea; methyl 3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-5-hydroxybenzoate;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-y l)-5 ,6-difluoro-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine;

Mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-5-fluoro-N-lH-pyrazol-5-yl-lH-benzimidazol-2-amine and l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-6-fluoro-N-lH-pyrazol-5-yl- 1 H-benzimidazol-2-amine;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y I)- 1 H-benzimidazol-2-yl)amino)-2-methoxy-phenol;

N-(I -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)- 1 H-indazol-6-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N- 1 H-indol-6-yl- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-cyclopropyl-lH-pyrazol-5-yl)-lH-benzimidazol-2-amine; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(3 -methoxypheny l)urea; methyl 4-(((4-(( 1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-phenyl)carbamoyl)amino)benzoate; 3 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y l)-5 ,6-dimethyl- 1 H-benzimidazol-2-yl)-amino)phenol;

N~5 — (l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-2,5-pyridine-diamine;

N-(I -(4-amino-6-methyl- 1,3, 5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)- lH-indazol-3-amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-hydroxybenzoic acid;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N- 1 H-indol-4-yl- 1 H-benzimidazol-2-amine;

N-(I -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)-4-fluoro- 1 H-indazol-3 -amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)phenol;

3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)benzoic acid; mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-5-bromo-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine and l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-6-bromo-N-lH-pyrazol-3-yl-1 H-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-y l)-5 ,6-dimethyl-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-3-pyridinyl-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-3-isoxazolyl-lH-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N- 1 H-pyrazol-4-yl- 1 H-benzimidazol-2-amine;

5-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-fluoro-phenol; methyl 1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-2-((3-methoxyphenyl)amino)- IH-benzimidazole-5-carboxylate;

3-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)benzamide;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-methyl-phenol;

(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-((3-methoxyphenyl)amino)-lH-benzimidazol-5-yl)methanol;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-4-fluorobenzenesulfonamide;

N-(I -(4-amino-6-methyl- 1,3, 5 -triazin-2-yl)- lH-benzimidazol-2-yl)-2,6-pyridine-diamine; 6-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2,3-dihydro-lH-inden-1-one;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-( 1 -methyl- 1 H-pyrazol-3 -yl)- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-methoxyphenyl)-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-cyclopropyl-lH-pyrazol-5-yl)-5,6-dimethyl- 1 H-benzimidazol-2-amine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-4-methylbenzenesulfonamide; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-methyl-5-isothiazolyl)-lH-benzimidazol- 2-amine;

3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-benzenesulfonamide;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N-phenyl- 1 H-benzimidazol-2-amine; N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-methanesulfonamide;

(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(3-methoxyphenylamino)-lH-benzo[d]-imidazol-6-yl)methanol;

methyl 4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-2-hydroxybenzoate; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(5-methyl-lH-pyrazol-3-yl)-lH-benzimidazol-2-amine; 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol- 2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-(2-furanyl)-lH-pyrazol-5-yl)-lH-benzimidazol-2-amine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-propanamide;

3 -(( 1 -(2-methyl-4-pyrimidinyl)- 1 H-benzimidazol-2-yl)amino)phenol;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-(3 -methylphenyl)- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-5,6-dimethyl-N-(3-methyl-lH-pyrazol-5-yl)-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-(l-methylethyl)-lH-pyrazol-5-yl)-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-chlorophenyl)-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-fluorophenyl)-lH-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-y l)-N-(3 -(2-thiophenyl)- 1 H-pyrazol-5 -yl)- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-((3RS)-tetrahydro-3-flιranyl)-lH-benzimidazol-2-amine; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-cyclopropyl- 1 H-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- IH-1 ,2,4-triazol-3 -yl- 1 H-benzimidazol-2-amine;

5-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-3-pyridinol; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(5-methyl-4H-l,2,4-triazol-3-yl)-lH-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)- 1 H-benzimidazol-2-amine;

N-(I -(4-amino-6-methyl- 1,3, 5-triazin-2-yl)-lH-benzimidazol-2-yl)-lH-pyrazolo[3,4-b] -pyridin-3 -amine;

N-(I -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)- 1 -methyl- 1 H-indazol-3 -amine;

5-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-2-pyridinol;

3 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)benzonitrile; N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-phenyl)acetamide;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N-(2,3-dihydro- 1 H-inden-2-yl)- 1 H-benzimidazol-2-amine;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)- 1 H-pyrazol-3-ol;

N-(I -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)- 1 H-benzimidazol-2-yl)- 1 -(cyclopropyl-methyl)-lH-indazol-3 -amine;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N-(2,3-dihydro- 1 H-inden- 1 -yl)- 1 H-benzimidazol-2-amine; 3 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y l)-5 ,6-dichloro- 1 H-benzimidazol-2-yl)-amino)phenol;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y I)- 1 H-benzimidazol-2-yl)amino)- 1 H-pyrazole-4-carbonitrile;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-( 1 -methyl- 1 H-pyrazol-5 -yl)- 1 H-benzimidazol-2-amine; ethyl 5-(( 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)- 1 H-pyrazole-4-carboxylate; methyl 3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-benzoate; 4-(2-((3-amino-lH-pyrazol-5-yl)oxy)-lH-benzimidazol-l-yl)-6-methyl-l,3,5-triazin-2-amine;

4-(2-(3-methoxyphenoxy)-lH-benzimidazol-l-yl)-6-methyl-l,3,5-triazin-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-imidazol-2-yl- 1 H-benzimidazol-2-amine; 4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y I)- 1 H-benzimidazol-2-yl)amino)-2,3 -dihydro- 1 H-isoindol- 1 -one; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-l,3-thiazol-2-yl-lH-benzimidazol-2-amine; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-2-hydroxy-phenyl)ethanone;

methyl l-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-cyclopropanecarboxylate;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-(3 -tert-butyl- 1 H-pyrazol-5 -yl)- 1 H-benzimidazol-2-amine; N-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-5-(trifluoromethyl)-lH-indazol-3 -amine;

1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-N-( 1 -(4-chlorophenyl)cyclopropyl)- 1 H-benzimidazol-2-amine; methyl 1 -(4-amino-6-methyl- 1 ,3 ,5-triazin-2-yl)-2-((3-methoxyphenyl)amino)- IH-benzimidazole-6-carboxylate; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-cyclohexyl-lH-pyrazol-5-yl)-lH-benzimidazol-2-amine;

3-((l-(6-amino-2-methyl-4-pyrimidinyl)-lH-benzimidazol-2-yl)amino)phenol;

3 -(( 1 -(6-pyrimidin-5 -ylamino-2-methyl-4-pyrimidiny I)- 1 H-benzimidazol-2-yl)-amino)phenol

1 -(6-amino-2-methyl-4-pyrimidinyl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine;

3 -(( 1 -(6-pyrimidin-2-ylamino-2-methyl-4-pyrimidiny I)- 1 H-benzimidazol-2-yl)-amino)phenol l-(6-amino-2-methyl-4-pyrimidinyl)-N-(3-cyclopropyl-l H-pyrazol-5 -yl)- IH-benzimidazol-2-amine;

3-((l-(2-amino-6-methyl-4-pyrimidinyl)-lH-benzimidazol-2-yl)oxy)phenol;

4-(2-(3 -methoxyphenoxy)- 1 H-benzimidazol- 1 -yl)-6-methyl-2-pyrimidinamine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-y l)-5 ,6-dichloro-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3- (4-methoxyphenyl)thiourea; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(3 -methoxypheny l)thiourea;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-4-methyl-N- 1 H-pyrazol-5 -yl- 1 H-benz-imidazol-2-amine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-2,6-dichlorobenzenesulfonamide;

((4-methyl-6-(2-( 1 H-pyrazol-3 -ylamino)- 1 H-benzimidazol- 1 -yl)- 1 ,3 ,5 -triazin-2-yl)-amino)acetonitrile ;

N-3-isoxazolyl-l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-lH-benzimidazol-2-amine;

((4-(2-(3-isoxazolylamino)-lH-benzimidazol-l-yl)-6-methyl-l,3,5-triazin-2-yl)amino)-acetonitrile; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-ethylthiourea; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(3 ,5 -dichlorophenyl)thiourea; and

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-2-(trifluoromethyl)benzenesulfonamide. l-(4-((l-(4-((cyanomethyl)amino)-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-amino)phenyl)-3 -methylurea; l-(4-((l-(4-((cyanomethyl)amino)-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-amino)phenyl)-3 -ethylurea; 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl-6-(5 -pyrimidinyl)- 1 H-benzimidazol-2-amine; l-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(4-pyridinyl)urea; mixture of l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-5-(2-methyl-4-pyridinyl)-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine and l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-6-(2-methyl-4-pyridinyl)-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine; mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-5-(lH-pyrazol-4-yl)-N-lH-pyrazol-5 -yl- 1 H-benzimidazol-2-amine and 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-6-( 1 H-pyrazol-4-yl)-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; mixture of l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-5-(5-pyrimidinyl)- 1 H-benzimidazol-2-amine and 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N-I H-pyrazol-3 -yl-6-(5-pyrimidinyl)-l H-benzimidazol-2-amine;

N-(4-((l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-amino)phenyl)acetamide; mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-5-yl-5-(4-pyridinyl)- 1 H-benzimidazol-2-amine; and l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-5-yl-6-(4-pyridinyl)- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-5-yl-6-(3-pyridinyl)-lH-benzimidazol-2-amine;

mixture of 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl-5 -( 1 ,2,3 ,6-tetrahydro-4-pyridinyl)- 1 H-benzimidazol-2-amine; and 1 -(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-6-(l,2,3,6-tetrahydro-4-pyridinyl)-lH-benzimidazol-2-amine; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-5 -yl-6-(4-pyridinyl)- 1 H-benzimidazol-2-amine; mixture of (5-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(lH-pyrazol-5-ylamino)-lH-benzimidazol-6-yl)-2-methoxyphenyl)methanol; and (5-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(l H-pyrazol-5 -ylamino)-lH-benzimidazol-5-yl)-2-methoxyphenyl)methanol; mixture of N-methyl-4-(l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-5-yl)benzamide; and N-methyl-4-(l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-6-yl)benzamide; mixture of 2-fluoro-N-methyl-4-( 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-2-(1 H-pyrazol-3 -ylamino)-lH-benzimidazol-5-yl)benzamide; and 2-fluoro-N-methyl-4-(l-(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-2-( 1 H-pyrazol-3 -ylamino)- 1 H-benzimidazol-6-yl)benzamide;

N-(4-((l-(4-((cyanomethyl)amino)-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)acetamide; mixture of ((4-(5-(3-(hydroxymethyl)-4-methoxyphenyl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-l-yl)-6-methyl-l,3,5-triazin-2-yl)amino)acetonitrile; and ((4-(6-(3-(hydroxymethyl)-4-methoxyphenyl)-2-( 1 H-pyrazol-3 -ylamino)- 1 H-benzimidazol- 1 -yl)-6-methyl-l,3,5-triazin-2-yl)amino)acetonitrile; mixture ofN-(4-(l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)- lH-benzimidazol-5-yl)phenyl)acetamide; and N-(4-(l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-6-yl)phenyl)acetamide; mixture of l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-5-(3-pyridinyl)- 1 H-benzimidazol-2-amine; and 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N-1 H-pyrazol-3 -yl-6-(3-pyridinyl)-l H-benzimidazol-2-amine; mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(lH-pyrazol-5-ylamino)-lH-benzimidazol-5-ol; and -(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(lH-pyrazol-5-ylamino)-lH-benzimidazol-6-ol;

mixture of ((4-methyl-6-(2-(lH-pyrazol-3-ylamino)-5-(4-pyridinyl)-lH-benzimidazol-l-yl)-l,3,5-triazin-2-yl)amino)acetonitrile; and ((4-methyl-6-(2-(l H-pyrazol-3 -ylamino)-6-(4-pyridinyl)- 1 H-benzimidazol- 1 -yl)- 1 ,3 ,5 -triazin-2-yl)amino)acetonitrile; mixture of l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-5-methoxy-N-lH-pyrazol-5-yl-lH-benzimidazol-2-amine; and l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-6-methoxy-N-lH-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; mixture of (2-methoxy-5-(l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-5-yl)phenyl)methanol; and (2-methoxy-5-(l -(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-6-yl)phenyl)methanol;

N~5~-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-2,5-pyrimidinediamine;

((4-(5 ,6-dimethyl-2-( 1 H-pyrazol-3 -ylamino)- 1 H-benzimidazol- 1 -yl)-6-methyl- 1,3,5-triazin-2-yl)amino)acetonitrile; 4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-methylbenzamide;

5 ,6-dimethyl- 1 -(4-methyl-6-(methy lamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine; mixture of l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-5-(4-pyridinyl)-l H-benzimidazol-2-amine; and l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-1 H-pyrazol-3 -yl-6-(4-pyridinyl)-l H-benzimidazol-2-amine; mixture of (5-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-2-(lH-pyrazol-5-ylamino)-lH-benzimidazol-5-yl)-2-methoxyphenyl)methanol;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)cyclopropanecarboxamide;

5 -(4-methoxyphenyl)- 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine;

3-((4-methyl-6-(2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-l-yl)-l,3,5-triazin-2-yl)amino)propanenitrile; 2-((4-methyl-6-(2-(lH-pyrazol-3-ylamino)-lH-benzimidazol-l-yl)-l,3,5-triazin-2-yl)amino)ethanol;

5 ,6-difluoro- 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine;

l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-5-yl-5-(4-pyridinyl)-lH-benzimidazol-2-amine; mixture of 5 -(4-fluorophenyl)- 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3-yl-lH-benzimidazol-2-amine; and 6-(4-fluorophenyl)-l-(4-methyl-6-(methylamino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-fluorophenol;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)- 1 ,3 -dihydro-2H-benzimidazol-2-one; 1 -(4-methyl-6-(methylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl-5 -(5 -pyrimidinyl)- 1 H-benzimidazol-2-amine;

1 -(4-((2-methoxyethyl)amino)-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine;

1 -(4-(cyclopropylamino)-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(6-methoxy-3-pyridinyl)-lH-benzimidazol-2-amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-ethyl-benzamide; 1 -(4-(benzylamino)-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol- 2-amine;

N-(I -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)- 1 H-indazol-4-amine;

1 -(4-methyl-6-((2-( 1 -piperaziny l)ethyl)amino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl-1 H-benzimidazol-2-amine; l-(4-methyl-6-((2-(4-morpholinyl)ethyl)amino)-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-1 H-benzimidazol-2-amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-4-pyridinylbenzamide; l-(4-(ethylamino)-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-lH-benzimidazol-2-amine;

N-(3-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)-phenyl)acetamide;

1 -(4-methyl-6-((tetrahydro-2H-pyran-4-ylmethyl)amino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3-yl-lH-benzimidazol-2-amine;

1 -(4-methyl-6-(tetrahydro-2H-pyran-4-ylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl-1 H-benzimidazol-2-amine; N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)- 2,3-dihydro-l-benzofuran-5-carboxamide;

1 -(4-methyl-6-(( 1 -methylethyl)amino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine; l-(4-((lH-imidazol-2-ylmethyl)amino)-6-methyl-l,3,5-triazin-2-yl)-N-lH-pyrazol-3-yl-1 H-benzimidazol-2-amine;

N-(I -(4-amino-6-methyl- 1,3, 5-triazin-2-yl)-lH-benzimidazol-2-yl)-l,4-benzene-diamine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3 -(dimethylamino)benzamide; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-( 1 -methyl- 1 H-pyrazol-4-yl)- 1 H-benzimidazol-2-amine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-cyclopentanecarboxamide;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-2,2-dimethylpropanamide;

1 -(4-((cyclopropylmethyl)amino)-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-2-pyrimidinyl- 1 H-benzimidazol-2-amine;

1 -(4-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benzimidazol-2-amine; N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)- 2, 1 ,3-benzothiadiazole-4-carboxamide;

1 -(4-methyl-6-(2-pyrimidinylamino)- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-3 -yl- 1 H-benz-imidazol-2-amine;

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-( 1 -methylethyl)benzamide; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(3-methylphenyl)-lH-benzimidazol-2-amine; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(l-(2,2,2-trifluoroethyl)-lH-pyrazol-3-yl)-1 H-benzimidazol-2-amine;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-4-pyrimidinyl- 1 H-benzimidazol-2-amine; 5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y I)- 1 H-benzimidazol-2-yl)amino)-N-methyl-lH-pyrazole-3-carboxamide; l-(4-((l-(4-((cyanomethyl)amino)-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-3-(3,5-dichlorophenyl)thiourea;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-2-pyrazinyl- 1 H-benzimidazol-2-amine; 3 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-y I)- 1 H-benzimidazol-2-yl)amino)benzonitrile; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-4-pyridazinyl- 1 H-benzimidazol-2-amine; 4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-pyrrolidinone;

5 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-cyclopropyl-lH-pyrazole-3-carboxamide;

1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-cyclopentyl- 1 H-benzimidazol-2-amine l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-3-pyridazinyl-lH-benzimidazol-2-amine; 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N-cyclohexyl- 1 H-benzimidazol-2-amine;

3 -(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-2-pyrrolidinone; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-3-pyrrolidinyl-lH-benzimidazol-2-amine; 1 -(4-(dimethylamino)-6-methyl- 1 ,3 ,5 -triazin-2-yl)-N- 1 H-pyrazol-5 -yl- 1 H-benzimidazol-2-amine;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-4-tert-butylbenzamide

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-cyclohexanecarboxamide; N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)- 3 -(trifluoromethyl)benzamide;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-4-(trifluoromethoxy)benzamide; ethyl 5-(( 1 -(4-amino-6-methyl- 1 ,3 ,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)- 1 H-pyrazole-3-carboxylate;

N-(4-((l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)amino)phenyl)-4-fluorobenzenesulfonamide; l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-N-(l-(4-morpholinylcarbonyl)-lH-pyrazol-4-yl)- 1 H-benzimidazol-2-amine;

N-(l-(4-amino-6-methyl-l,3,5-triazin-2-yl)-lH-benzimidazol-2-yl)-l,3-benzoxazol-6-amine; and

4-(( 1 -(4-amino-6-methyl- 1,3,5 -triazin-2-yl)- 1 H-benzimidazol-2-yl)amino)-N-4-pyridinyl- 1 H-pyrazole- 1 -carboxamide; or a pharmaceutcally acceptable salt thereof

18. A pharmaceutical composition comprising a compound of any of the Claims 1-17 and a pharmaceutically acceptable excipient. .

19. A compound of any of the Claims 1 - 17 for use in therapy.

20. Use of a compound of any of the Claims 1-17 in the manufacture of a medicament for the treatment of cancer.