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1. (WO2017205766) INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE

Pub. No.:    WO/2017/205766    International Application No.:    PCT/US2017/034721
Publication Date: Fri Dec 01 00:59:59 CET 2017 International Filing Date: Sat May 27 01:59:59 CEST 2017
IPC: C07D 471/04
C07D 487/04
C07D 495/04
A61K 31/519
A61P 35/00
Applicants: PHARMACYCLICS LLC
Inventors: CHEN, Wei
JIA, Zhaozhong, J.
THOMAS, William, D.
WONE, David
MORIN, Matthew, D.
Title: INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
Abstract:
Disclosed herein are inhibitors of IRAK protein kinase of formula (I). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the IRAK inhibitors are described, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.