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International application No. Applicant's or agent's file reference
PCT/GB2018/053745 i30905WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
21 December 2018 21 December 2017
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     G16H 50/30 (2018.01)i; G16H 20/00 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     G16H; A61B; G06F
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
US 2009054908 A1 (ZAND JASON MATTHEW [US] ET AL) 26 February 2009 (2009-02-26)
paragraphs [0008] - [0009]
paragraph [0056]
paragraph [0075]
paragraph [0093]
paragraphs [0106] - [0108]
US 2017231701 A1 (COHEN DVIR [IL] ET AL) 17 August 2017 (2017-08-17)
paragraph [0484]
EP 0917078 A1 (SMITHKLINE BEECHAM CORP [US]) 19 May 1999 (1999-05-19)
paragraph [0005]
US 2014108045 A1 (AFSHAR SALIM [US] ET AL) 17 April 2014 (2014-04-17)
paragraph [0008]
US 2016055307 A1 (MACOVIAK JOHN A [US] ET AL) 25 February 2016 (2016-02-25)
paragraphs [0004], [0108], [0127], [0129]
US 2015255004 A1 (MANZKE ROBERT [DE] ET AL) 10 September 2015 (2015-09-10)
paragraphs [0022], [0029]
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
US 2009054908 A1
26 February 2009
CA 2604563 A1
CN 101495025 A
CN 103622725 A
EP 1868485 A2
EP 3095379 A1
US 2009054908 A1
US 2016073909 A1
WO 2006113394 A2
26 October 2006
29 July 2009
12 March 2014
26 December 2007
23 November 2016
26 February 2009
17 March 2016
26 October 2006
US 2017231701 A1
17 August 2017
CA 2957620 A1
CA 2957622 A1
CA 2957624 A1
CN 106714655 A
EP 3188645 A2
EP 3188682 A2
JP 2017533057 A
US 2017071687 A1
US 2017071688 A1
US 2017112581 A1
US 2017112583 A1
US 2017119483 A1
US 2017135776 A1
US 2017231701 A1
US 2019000574 A1
WO 2016035084 A2
WO 2016035085 A2
WO 2016035086 A2
10 March 2016
10 March 2016
10 March 2016
24 May 2017
12 July 2017
12 July 2017
09 November 2017
16 March 2017
16 March 2017
27 April 2017
27 April 2017
04 May 2017
18 May 2017
17 August 2017
03 January 2019
10 March 2016
10 March 2016
10 March 2016
EP 0917078 A1
19 May 1999
AU 3930797 A
CA 2216681 A1
EP 0917078 A1
JP H10198750 A
NZ 328870 A
ZA 9708698 B
02 April 1998
30 March 1998
19 May 1999
31 July 1998
28 May 1999
03 August 1998
US 2014108045 A1
17 April 2014
US 2014107461 A1
US 2014108045 A1
17 April 2014
17 April 2014
US 2016055307 A1
25 February 2016
US 2014058755 A1
US 2014089001 A1
US 2015142466 A1
US 2016055307 A1
WO 2013077977 A1
27 February 2014
27 March 2014
21 May 2015
25 February 2016
30 May 2013
US 2015255004 A1
10 September 2015
CN 104704543 A
EP 2904601 A1
JP 6306024 B2
JP 2015533245 A
US 2015255004 A1
WO 2014053940 A1
10 June 2015
12 August 2015
04 April 2018
19 November 2015
10 September 2015
10 April 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 March 2019
Date of mailing of the international search report:
29 March 2019
Authorized officer:
Reinbold, Bernhard
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