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1. WO2026085569 - LAMBDA MYELOMA ANTIGEN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Publication Number WO/2026/085569
Publication Date 30.04.2026
International Application No. PCT/AU2025/051199
International Filing Date 22.10.2025
IPC
A61K 40/42 2025.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
40Cellular immunotherapy
40characterised by antigens that are targeted or presented by cells of the immune system
41Vertebrate antigens
42Cancer antigens
A61K 40/11 2025.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
40Cellular immunotherapy
10characterised by the cell type used
11T-cells, e.g. tumour infiltrating lymphocytes or regulatory T cells; Lymphokine-activated killer cells
A61K 40/31 2025.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
40Cellular immunotherapy
30characterised by the recombinant expression of specific molecules in the cells of the immune system
31Chimeric antigen receptors
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
CPC
A61K 2239/13
A61K 2239/17
A61K 2239/21
A61K 2239/22
A61K 2239/48
A61K 40/11
Applicants
  • HAEMALOGIX LTD [AU]/[AU]
Inventors
  • DUNN, Rosanne
Agents
  • FB RICE PTY LTD
Priority Data
202490342922.10.2024AU
202590398929.08.2025AU
Publication Language English (en)
Filing Language English (en)
Designated States
Title
(EN) LAMBDA MYELOMA ANTIGEN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
(FR) RÉCEPTEURS ANTIGÉNIQUES CHIMÉRIQUES DE L'ANTIGÈNE DU MYÉLOME LAMBDA ET LEURS UTILISATIONS
Abstract
(EN) The present disclosure relates to chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain comprising a modified single chain variable fragment (scFv) that specifically recognises lambda myeloma antigen (LMA). The present disclosure also relates to a polynucleotide encoding the CAR, vectors, genetically modified cells and uses thereof.
(FR) La présente divulgation concerne un récepteur antigénique chimérique (CAR) comprenant un domaine de liaison à l'antigène extracellulaire comprenant un fragment variable simple chaîne (scFv) modifié qui reconnaît spécifiquement l'antigène du myélome lambda (LMA). La présente divulgation concerne également un polynucléotide codant pour le CAR, des vecteurs, des cellules génétiquement modifiées et leurs utilisations.

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The publication of an international application under the Patent Cooperation Treaty in PATENTSCOPE (which constitutes an element of the Gazette) does not imply the expression of any opinion whatsoever on the part of the International Bureau of WIPO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.