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1. (WO2008077560) PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS

Pub. No.:    WO/2008/077560    International Application No.:    PCT/EP2007/011180
Publication Date: Fri Jul 04 01:59:59 CEST 2008 International Filing Date: Thu Dec 20 00:59:59 CET 2007
IPC: C07C 213/00
C07C 215/60
Applicants: LONZA AG
MCGARRITY, John
ZANOTTI-GEROSA, Antonio
Inventors: MCGARRITY, John
ZANOTTI-GEROSA, Antonio
Title: PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS
Abstract:
Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is hydrogen, C1-6alkyl or aryl-substituted C1-6alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoacetophenones in the presence of a ruthenium complex catalyst comprising a chiral phosphine ligand.