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1. (WO2008077560) PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/077560    International Application No.:    PCT/EP2007/011180
Publication Date: 03.07.2008 International Filing Date: 19.12.2007
IPC:
C07C 213/00 (2006.01), C07C 215/60 (2006.01)
Applicants: LONZA AG [CH/CH]; Münchensteinerstr. 38, CH-4052 Basel (CH) (For All Designated States Except US).
MCGARRITY, John [CH/CH]; (CH) (For US Only).
ZANOTTI-GEROSA, Antonio [IT/GB]; (GB) (For US Only)
Inventors: MCGARRITY, John; (CH).
ZANOTTI-GEROSA, Antonio; (GB)
Common
Representative:
LONZA AG; Münchensteinerstr. 38, CH-4052 Basel (CH)
Priority Data:
06026754.9 22.12.2006 EP
Title (EN) PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS
(FR) PROCÉDÉ DE PRÉPARATION DE 2-AMINO-1-PHÉNYLÉTHANOLS OPTIQUEMENT ACTIFS
Abstract: front page image
(EN)Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is hydrogen, C1-6alkyl or aryl-substituted C1-6alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoacetophenones in the presence of a ruthenium complex catalyst comprising a chiral phosphine ligand.
(FR)La présente invention concerne des 2-amino-1-phényléthanols optiquement actifs de formule (I) ou son image miroir, dans laquelle R1 est hydrogène, alkyle C1-C6 ou alkyle C1-C6 à substitution aryle et R2 à R6 sont indépendamment hydrogène, hydroxy ou alcoxy C1-C6, ou leurs sels préparés par l'hydrogénation asymétrique de 2-aminoacétophénones correspondants en présence d'un catalyseur à base de complexe de ruthénium comprenant un ligand de type phosphine chirale.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)