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1. WO2015003571 - NOVEL CRYSTAL FORM OF DABRAFENIB MESYLATE AND PREPARATION METHOD THEREOF

Publication Number WO/2015/003571
Publication Date 15.01.2015
International Application No. PCT/CN2014/081549
International Filing Date 03.07.2014
IPC
C07D 417/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/506 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • 杭州普晒医药科技有限公司 HANGZHOU PUSHAI PHARMACEUTICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 劳海萍 LAO, Haiping
  • 盛晓霞 SHENG, Xiaoxia
  • 盛晓红 SHENG, Xiaohong
Agents
  • 北京邦信阳专利商标代理有限公司 BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE
Priority Data
201310283705.408.07.2013CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NOVEL CRYSTAL FORM OF DABRAFENIB MESYLATE AND PREPARATION METHOD THEREOF
(FR) NOUVELLE FORME CRISTALLINE DE MÉSYLATE DE DABRAFENIB ET PROCÉDÉ DE PRÉPARATION DE CELLE-CI
(ZH) 达拉菲尼甲磺酸盐的新晶型及其制备方法
Abstract
(EN) Disclosed are a novel crystal form of Dabrafenib mesylate and preparation method thereof. The novel crystal form of the present invention is more stable in water or an aqueous system, and has greater solubility and dissolution in water, thus having better stability and bioavailability compared with the existing crystal forms.
(FR) La présente invention se rapporte à une nouvelle forme cristalline de mésylate de dabrafenib et un procédé de préparation de celle-ci. La nouvelle forme cristalline selon la présente invention est plus stable dans l'eau ou un système aqueux, et présente une meilleure solubilité et dissolution dans l'eau, ce qui lui confère une plus grande stabilité et une biodisponibilité plus élevée comparativement aux formes cristallines existantes.
(ZH) 本发明涉及达拉菲尼甲磺酸盐的新晶型及其制备方法。本发明所述新晶型具有在水或含水体系中更稳定和水中溶解度、溶出量更大的优点,因此相对于现有的晶型,具有更好的稳定性和生物利用度。
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