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24. (US20150374667) Compositions and method for treatment of ischemic neuronal reperfusion injury

Application Number: 14626126 Application Date: 19.02.2015
Publication Number: 20150374667 Publication Date: 31.12.2015
Grant Number: 09248118 Grant Date: 02.02.2016
Publication Kind : B2
IPC:
A61K 31/4178
C07D 405/12
A61K 45/06
A61K 38/05
CPC:
A61K 31/4178
A61K 31/13
A61K 31/355
A61K 31/40
A61K 31/5513
A61K 31/5517
A61K 31/59
A61K 31/765
A61K 38/05
A61K 45/06
A62B 17/00
C07D 405/12
Y10T 428/2982
Applicants: Howard University
Inventors: Harpal S. Mangat
Pradeep K. Karla
Agents: Fitch Even Tabin & Flannery LLP
Priority Data:
Title: (EN) Compositions and method for treatment of ischemic neuronal reperfusion injury
Abstract:
(EN)

A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.