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1. WO2018015213 - SITE-SPECIFIC CONJUGATION TO ANTIBODY LYSINE RESIDUES WITH SOLID-PHASE IMMOBILIZED MICROBIAL TRANSGLUTAMINASE MTG AND MTG IN SOLUTION


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2017/067403 2016P14952WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
11 July 2017 20 July 2016
Applicant
PAUL SCHERRER INSTITUT
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 47/64 (2017.01)i; A61K 47/68 (2017.01)i; C12N 11/08 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, COMPENDEX, EMBASE, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
ZHOU JIAN QIN ET AL, "The microbial transglutaminase immobilization on carboxylated poly(N-isopropylacrylamide) for thermo-responsivity", ENZYME AND MICROBIAL TECHNOLOGY,Vol. 87, 26 February 2016 (2016-02-26), page 44-51,
XP029536345
1-5,7-14
Y
whole document and in particular section 2.2.2 on page 45; sections 2.2.6 and 2.2.7 on page 46; Scheme 1
1-12
(2)
X
Patrick Dennler, "Microbial Transglutaminase as a Versatile Tool for Site-Specific Protein Modification", 01 January 2015 (2015-01-01),
Retrieved from the Internet:
URL:https://e-collection.library.ethz.ch/eserv/eth:47580/eth-47580-02.pdf#search=
XP055335666
[retrieved on  2017-01-16]
1,4-9,11,14
Y
pages 21-22, paragraph 1.8.2
1-12
page 30, line 2.4.2
page 44; figure 3.2
page 49, paragraph 3.3.4
pages 52-56, paragraphs 3.4.2,3.4.3
page 74, paragraph 4.5.14
pages 96-97, and in particular the first full paragraph on page 97
(3)
Y
EP 2287317 A2 (DANISCO [DK]) 23 February 2011 (2011-02-23)
1-12
paragraphs [0107] - [0109], [0413], [0414]
(4)
Y
ROIG M G ET AL, "Biotechnology and applied biology section applications of immobilized enzymes", 01 October 1987 (1987-10-01), Vol. 15, No. 4, page 198-208,
XP024357753
[retrieved on  1987-10-01]
1-12
whole document and in particular the introduction; section "Enzyme reactors" on pages 198-199
(5)
Y
SANGHA. OH ET AL, "Characteristics of an immobilized form of transglutaminase: A possible increase in substrate specificity by selective interaction with a protein spacer", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,Vol. 41, No. 8, 01 August 1993 (1993-08-01), page 1337-1342,
XP055335631
2,10,12
whole document and in particular the abstract and Figure 1
(6)
X
F. LHOSPICE ET AL, "Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models", MOLECULAR PHARMACEUTICS,Vol. 12, No. 6, 01 June 2015 (2015-06-01), page 1863-1871,
XP055327463
1,4-9,11,14
page 1865-1866, "Preparation of ADCs Using BTG"
(7)
X
JEGER S ET AL, "Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase", ANGEWANDTE CHEMIE - INTERNATIONAL EDITION 20101217 WILEY-VCH VERLAG DEU,Vol. 49, No. 51, 17 December 2010 (2010-12-17), page 9995-9997,
XP002774693
1,4-9,11,14
the whole document
& Simone Jeger ET AL, "Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase - SUPPORTING INFORMATION",  Angewandte Chemie International Edition,Vol. 49, No. 51, 17 December 2010 (2010-12-17), page e1-e46,
XP055080950
the whole document
(8)
T
PHILIPP R. SPYCHER ET AL, "Dual, Site-Specific Modification of Antibodies by Using Solid-Phase Immobilized Microbial Transglutaminase", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY.,Vol. 18, No. 19, 05 October 2017 (2017-10-05), page 1923-1927,
XP055415819
1-14
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
EP 2287317 A2
23 February 2011
AT 487796 T
AT 506440 T
AT 533849 T
AT 533850 T
AU 2004205539 A1
AU 2004206113 A1
BR PI0406602 A
BR PI0406770 A
BR 122016015076 B1
CA 2511252 A1
CA 2512734 A1
CN 102021205 A
CN 102021206 A
DK 1599278 T3
DK 1619961 T3
DK 1748074 T3
DK 1762622 T3
DK 2278015 T3
DK 2287317 T3
EP 1599278 A2
EP 1619961 A2
EP 1748074 A2
EP 1762622 A2
EP 2278015 A1
EP 2287317 A2
EP 2290085 A2
ES 2364654 T3
ES 2374132 T3
ES 2375492 T3
ES 2521681 T3
ES 2525711 T3
JP 4778887 B2
JP 4804340 B2
JP 2006521787 A
JP 2006524037 A
PT 1619961 E
PT 1748074 E
PT 1762622 E
SI 1619961 T1
WO 2004064537 A2
WO 2004064987 A2
15 November 2010
15 May 2011
15 December 2011
15 December 2011
05 August 2004
05 August 2004
01 March 2006
20 December 2005
16 May 2017
05 August 2004
05 August 2004
20 April 2011
20 April 2011
18 July 2011
17 January 2011
05 March 2012
16 January 2012
13 October 2014
05 January 2015
30 November 2005
01 February 2006
31 January 2007
14 March 2007
26 January 2011
23 February 2011
02 March 2011
08 September 2011
14 February 2012
01 March 2012
13 November 2014
29 December 2014
21 September 2011
02 November 2011
28 September 2006
26 October 2006
11 January 2011
16 January 2012
13 January 2012
31 March 2011
05 August 2004
05 August 2004
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
16 October 2017
Date of mailing of the international search report:
25 October 2017
Authorized officer:
Villard, Anne-Laure
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