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1. IN202111010632 - A NOVEL DRUG FOR SARS-COV-2

Office
India
Application Number 202111010632
Application Date 13.03.2021
Publication Number 202111010632
Publication Date 28.05.2021
Publication Kind A
IPC
G16B
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
G16C
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
A61K
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Applicants Abhay J. Gandhi
Jalpa D. Rupareliya
Gaurav Sharma
Akshay J. Gandhi
V J Shukla
Sudipt Rath
Mita Kotecha
Prashant Bedarkar
Mukesh Chaudhari
Inventors Abhay J. Gandhi
Jalpa D. Rupareliya
Gaurav Sharma
Akshay J. Gandhi
V J Shukla
Sudipt Rath
Mita Kotecha
Prashant Bedarkar
Mukesh Chaudhari
Title
(EN) A NOVEL DRUG FOR SARS-COV-2
Abstract
(EN) COVID-19, a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. It then extended across the globe and was termed as pandemic in 2020. Though no vaccine or drug is available to combat this disease, it is necessary to look over it through alternative sciences. Available symptoms of covid 19 was thoroughly studied and reviewed through Ayurveda classics to understand the nature of the disease into Ayurevdic perspective. Other available sources from internet, pre prints, etc. The molecular Docking were done by Pyrx Software with Autodock. The Lipinski Rule of Five data generated from Swiss ADME software and Target prediction of selected phytoconstituents were done from Swiss target prediction.In Ayurveda, it can be considered as Janapadaudhwans, vaat-kafaj sannipatik jwara, Aupsargik vyadhi and Dhatupaka awastha. In the molecular docking study the binding energy and inhibition of 6 Gingesulphonic acid from Zingiber Officinalis are greater than Hydroxychloroquine and quinine. Most of the selected phytoconstituents follow Lipinski rule of five. Target prediction of selected phytoconstituents were done on target of SARS-COV-2, humoral immunity and antiviral. Every selected phytoconstituents were work on minimum of the target.Thus, from the above results obtained from reviewing Ayurveda classics and from the results obtained after virtual screening of selected drugs we can conclude that Ayurveda drugs can have appreciable results in combating Covid 19.