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1. WO2020136648 - CANNABIDIOLIC ACID ESTERS FOR COSMETIC OR EDIBLE COMPOSITIONS

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[ EN ]

CLAIMS

1. A cosmetic or edible composition comprising a cannabinoid component, wherein the cannabinoid component comprises a cannabidiolic acid (CBDA) ester represented by the structure of Formula (I), alone or in combination with one or more additional cannabinoid compound(s), and a physiologically acceptable carrier, excipient or diluent,


Formula I

wherein

Ri and I¾ are each independently selected from the group consisting of a linear or branched Ci-Cio alkyl, a linear or branched C2-C10 alkenyl, and a linear or branched C2-C10 alkynyl;

and stereoisomers and salts thereof;

and with the proviso that when the composition comprises a CBDA ester of formula (I) wherein Ri is methyl and R2 is a C3 or C5 linear alkyl, the

CBDA ester comprises more than 50% of the total weight of the cannabinoids in the composition.

2. The composition according to claim 1 , wherein R2 is other than a C5 linear alkyl.

3. The composition according to claim 1 or 2, wherein R2 is other than a C3 linear alkyl.

4. The composition according to claim 1 , wherein Ri is methyl.

5. The composition according to claim 4, wherein the cannabidiolic acid ester is cannabidiolic acid methyl ester (CBDA- ME).

6. The composition according to any one of claims 1 to 5, further comprising one or more additional cannabinoid compound selected from the group consisting of cannabidiol (CBD), cannabigerol (CBG), A8-tetrahydrocannabinol (AS-TF1C), D9- tetrahydrocannabinol (A9-TF1C), cannabinol (CBN), A9(l l)-tetrahydrocannabinol (exo-TFIC), cannabichromene (CBC), tetrahydrocannabinol-C3 (TF1C-C3), tetrahydrocannabinol-C4 (TF1C-C4), tetrahydrocannabinol-C7 (TF1C-C7), esters thereof and combinations thereof.

7. The composition according to claim 1, wherein the one or more additional cannabinoid compound(s) are present in one or more extracts of a cannabis plant.

8. The composition according to claim 7, wherein the cannabis plant extract is obtained from a strain selected from the group consisting of Cannabis sativa, Cannabis indica, Cannabis ruderalis, a hybrid strain, and combinations thereof.

9. The composition according to claim 7 or 8, the cannabis plant extract is obtained from a strain selected from the group consisting of a high-CBD strain, a high- THC strain, and a combination thereof.

10. The composition according to claim 7, wherein the cannabis plant extract comprises at least one cannabinoid selected from the group consisting of cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), acids thereof and combinations thereof.

11. The composition according to claim 7, wherein cannabis plant extract comprises from about 1% to about 25% (w/w) of CBD.

12. The composition according to claim 7, wherein cannabis plant extract comprises from about 1 % to about 25 % (w/w) of THC.

13. The composition according to claim 7, wherein the cannabis plant extract is formed in contacting with a suitable solvent or a combination of solvents.

14. The composition according to claim 13, wherein the solvent is selected from the group consisting of a polar solvent, a hydrocarbon solvent, carbon dioxide, and combinations thereof.

15. The composition according to any one of claims 1 to 14, comprises from 0.01% to about 8% (w/w) of the cannabinoid component.

16. The composition according to any one of claims 1 to 15, wherein the cannabinoid component is emulsified, dissolved, dispersed or encapsulated in formulations suitable for use in either aqueous based or oil-based carriers.

17. The composition according to any one of claims 1 to 16, wherein said composition is a cosmetic composition selected from the group consisting of a make-up product, a foundation product, and a skin-care product.

18. The composition according to claim 17 for use in improving appearance, well being and/or general health.

19. The composition for use according to claim 18, further comprising an excipient selected from the group consisting of viscosity modifiers, emulsifiers, film- forming agents, foaming agents, colorants, preservatives, fragrance agents, solvents, electrolytes, pH adjusting agents, and combinations thereof.

20. The composition according to any one of claims 1 to 19, further comprising a cosmetically- active ingredient selected from the group consisting of sunscreen agents, anti-wrinkle and anti-aging agents, skin peel agents, whitening and bleaching agents, sunless tanning agents, vitamins, skin conditioning agents, and combinations thereof.

21. The composition according to any one of claims 1 to 20, in the form selected from the group consisting of powder, ointment, cream, milk, lotion, gel, emulsion, emulsified gel, mousse, foam, spray, liquid, paste, serum, and aerosol.

22. A method for improving the appearance of skin comprising applying topically to the skin of a subject the cosmetic composition according to any one of claims 1 to 21.

23. The composition according to any one of claims 1 to 16, wherein said composition is an edible composition selected from the group consisting of food products, nutraceuticals, beverages, and animal feed.

24. The composition according to claim 23 for use in improving appearance, well being and/or general health.

25. The composition according to claim 24, further comprises a phospholipid selected from the group consisting of soy lecithin, egg lecithin, hydrogenated soy lecithin, hydrogenated egg lecithin, and a combination thereof.

26. The composition according to claim 25, wherein the phospholipid forms micelles, emulsions or liposomes.

27. The composition according to claim 25, wherein the phospholipid forms liposomes.

28. The composition according to claim 25, further comprising cholesterol.

29. The composition according to any one of claims 24 to 28 further comprising an edible excipient selected from the group consisting of fillers, emulsifiers, anticaking agents, preservatives, colorants, flavoring agents, and combinations thereof.

30. The composition according to any one of claims 24 to 29, further comprises a nutrient selected from the group consisting of vitamins, minerals, and combinations thereof.

31. The composition according to any one of claims 24 to 30, said composition is in a form selected from the group consisting of powder, flake, granular, capsule, tablet, syrup, solution, emulsion and suspension.

32. The composition for use according to any one of claims 24 to 31, wherein the food product is selected from the group consisting of bread, cereals, pasta, pastry, biscuits, candy, and confectionary.

33. The composition for use according to any one of claims 24 to 32, wherein the composition is a beverage.

34. A method for improving the physical well-being and/or the mental perception of well-being of a subject comprising consuming by said subject the edible composition according to any one of claims 23 to 34.