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1. WO2011144714 - KISSORPHIN PEPTIDES FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE, CREUTZFELDT- JAKOB DISEASE OR DIABETES MELLITUS

Publication Number WO/2011/144714
Publication Date 24.11.2011
International Application No. PCT/EP2011/058213
International Filing Date 19.05.2011
Chapter 2 Demand Filed 19.03.2012
IPC
A61K 38/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 38/07 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
A61K 38/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
C07K 2/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2Peptides of undefined number of amino acids; Derivatives thereof
C07K 5/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
CPC
A61K 38/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 38/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/1709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
1709from mammals
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants
  • ROEHAMPTON UNIVERSITY [GB]/[GB] (AllExceptUS)
  • MILTON, Nathaniel [GB]/[GB] (UsOnly)
Inventors
  • MILTON, Nathaniel
Agents
  • JAPPY, John
Priority Data
10163479.820.05.2010EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) KISSORPHIN PEPTIDES FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE, CREUTZFELDT- JAKOB DISEASE OR DIABETES MELLITUS
(FR) PEPTIDES KISSORPHINE POUR L'UTILISATION DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER, LA MALADIE DE CREUTZFELDT-JAKOB OU LE DIABÈTE SUCRÉ
Abstract
(EN) The present invention is directed to Kissorphin peptides (Tyr-Asn-Trp-Asn-Ser-Phe) and derivatives or analogs thereof that target Amyloid fibril-forming peptides. The Kissorphin peptides are highly specific therapeutic reagents that are useful in detecting, preventing and treating diseases associated with Amyloid fibril-forming peptides, such as Alzheimer's disease, Creutzfeldt-Jakob disease or Diabetes mellitus. According to the invention, a peptide comprises the amino acid sequence defined herein as SEQ ID No. 2, for use in the treatment of a condition associated with Amyloid fibril-forming peptides, wherein the peptide does not directly activate or inhibit the GPR-54 G-protein coupled receptor. Antibodies against Kissorphin peptides and methods for determining whether a subject has, or is predisposed to having, a disorder associated with Amyloid fibril formation are also described.
(FR) La présente invention concerne des peptides Kissorphine (Tyr-Asn-Trp-Asn-Ser-Phe) et des dérivés ou des analogues de ceux-ci qui ciblent des peptides formant des fibrilles amyloïdes. Les peptides Kissorphine sont des réactifs thérapeutiques hautement spécifiques qui sont utiles dans la détection, la prévention et le traitement de maladies associées à des peptides formant des fibrilles amyloïdes, telles que la maladie d'Alzheimer, la maladie de Creutzfeldt-Jakob ou le diabète sucré. Selon l'invention, un peptide comprend la séquence d'acides aminés définie dans la présente invention comme SEQ ID No. 2, pour l'utilisation dans le traitement d'un état associé à des peptides formant des fibrilles amyloïdes, le peptide n'activant ou n'inhibant pas directement le récepteur GPR-54 couplé à une protéine G. L'invention porte également sur des anticorps contre des peptides Kissorphine et sur des procédés de détermination dans le cas où un sujet présente ou est prédisposé à présenter un trouble associé à la formation de fibrilles amyloïdes.
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