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1. (WO2013123298) NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123298    International Application No.:    PCT/US2013/026299
Publication Date: 22.08.2013 International Filing Date: 15.02.2013
IPC:
A61K 31/66 (2006.01)
Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; Boyd Graduate Studies Research Center Athens, GA 30602-7411 (US)
Inventors: DHAR, Shanta; (US).
MARRACHE, Sean, M.; (US)
Agent: CAMPBELL, Keith, M.; Mueting Raasch & Gebhardt, P.A. P.O. Box 581336 Minneapolis, MN 55458-1336 (US)
Priority Data:
61/600,088 17.02.2012 US
Title (EN) NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS
(FR) NANOPARTICULES DE TRAFIC MITOCHONDRIAL D'AGENTS
Abstract: front page image
(EN)Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.
(FR)La présente invention concerne des nanoparticules comprenant un noyau, une couche hydrophile entourant le noyau et une ou plusieurs fractions de ciblage mitochondrial, et pouvant éventuellement comprendre un ou plusieurs agents de contraste ou un ou plusieurs agents thérapeutiques. Selon l'invention, pour un ciblage mitochondrial efficace, les nanoparticules ont un diamètre d'environ 200 nm au maximum ou ont un potentiel zêta d'environ 0 mV au minimum.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)