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1. WO2020140040 - DEVICES AND METHODS FOR DELIVERY OF SUBSTANCES WITHIN A PREFILLED SYRINGE

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[ EN ]

What is claimed is:

1. An apparatus, comprising:

a housing defining a gas chamber, a side wall of the housing defining an opening configured to selectively place the gas chamber in fluid communication with an exterior volume;

a carrier disposed within the housing, a proximal surface of the carrier defining a portion of a boundary of the gas chamber;

a medicament container coupled to the carrier, a distal end portion of the medicament container configured to be coupled to a delivery member, the medicament container containing a medicament and including an elastomeric member that seals the medicament within the medicament container; and

a flexible member, a distal end portion of the flexible member coupled to the elastomeric member, a proximal end portion of the flexible member coupled to a valve member, the flexible member configured to transition from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container, the flexible member configured to exert a release force on the valve member to move the valve member relative to the opening when the flexible member transitions from the collapsed configuration to the expanded configuration to place the gas chamber in fluid communication with the exterior volume.

2. The apparatus of claim 1, wherein the flexible member is at least one of a filament or a band.

3. The apparatus of claim 2, wherein the flexible member is overmolded with a plastic material.

4. The apparatus of any of claims 1-3, wherein the valve member moves in a distal direction when the flexible member transitions from the collapsed configuration to the expanded configuration and the elastomeric member continues to move in the distal direction.

5. The apparatus of claim 4, wherein the elastomeric member pulls the valve member via the flexible member when the flexible member is in the expanded configuration.

6. The apparatus of any of claims 1-3, wherein:

the valve member moves in a distal direction when the flexible member transitions from the collapsed configuration to the expanded configuration; and

the valve member includes a locking protrusion configured to engage a corresponding locking surface to limit movement of the valve member in a proximal direction.

7. The apparatus of any of claims 1-3, wherein:

the distal end portion of the flexible member is coupled to the elastomeric member via a coupling member, the coupling member including a retention structure; and

the valve member includes a locking protrusion configured to engage the retention structure of the coupling member when the flexible member is in the collapsed configuration, the locking protrusion configured to release from the retention structure when a gas pressure within the gas chamber exceeds a threshold pressure value.

8. The apparatus of any of claims 1-3, wherein the elastomeric member moves within the medicament container through a stroke distance to convey a dose of the medicament from the medicament container via the delivery member in response to a pressurized gas being conveyed into the gas chamber.

9. The apparatus of claim 6, wherein a length of the flexible member in the expanded configuration corresponds to the stroke distance, the length controlling a volume of the dose delivered.

10. The apparatus of claim 1, wherein:

the delivery member is a needle; and

the medicament container is a prefilled syringe, the needle being staked to a distal end portion of a container body of the prefilled syringe.

11. The apparatus of claim 8, wherein the medicament within the prefilled syringe is any one of a drug or a biologic product.

12. The apparatus of claim 8, wherein the medicament comprises icatibant.

13. The apparatus of claim 8, wherein the medicament comprises a monoclonal antibody.

14. The apparatus of claim 1, further comprising:

a container within the housing, the container configured to produce a pressurized gas within the gas chamber when the container is actuated.

15. The apparatus of any of claims 1-3, wherein:

the valve member includes a valve protrusion; and

the valve protrusion defines a passageway to place the gas chamber in fluid communication with the exterior volume when the valve member is moved relative to the opening.