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1. WO2020139667 - ORAL CARE COMPOSITIONS

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[ EN ]

What is claimed is:

1. An oral care composition, comprising:

a catalyzing enzyme; and

an anhydrous matrix configured to at least partially stabilize the catalyzing enzyme, wherein the anhydrous matrix comprises:

a source of hydrogen peroxide;

an acyl donor;

a non-aqueous anhydrous liquid; and

a surfactant mixture,

wherein the surfactant mixture comprises sodium lauryl sulfate (SLS), Betaine, and a poloxamer having a molecular weight of 5,000 or more Daltons.

2. The oral care composition of claim 1, wherein the poloxamer in the surfactant mixture is at least one of an ethylene oxide-propylene oxide polymer or a polyethylene glycol / polypropylene glycol (PEG/PPG) copolymer, and

wherein the betaine is anhydrous cocamidopropyl betaine.

3. The oral care composition of claim 2, wherein the surfactant mixture comprises: from about 0.5 weight % to about 5.0 weight % SLS, based on a total weight of the oral care composition;

from about 0.01 weight % to about 5.0 weight % anhydrous cocamidopropyl betaine, based on the total weight of the oral care composition; and

from about 0.5 weight % to about 20.0 weight % of the PEG/PPG copolymer, based on the total weight of the oral care composition.

4. The oral care composition of claim 2, wherein the surfactant mixture comprises: from about 0.5 weight % to about 3.0 weight % SLS, based on a total weight of the oral care composition;

from about 0.5 weight % to about 3.0 weight % anhydrous cocamidopropyl betaine, based on the total weight of the oral care composition; and

from about 2.0 weight % to about 10.0 weight % of the PEG/PPG copolymer, based on the total weight of the oral care composition.

5. The oral care composition of claim 2, wherein the surfactant mixture consists essentially of:

from about 1.0 weight % to about 2.0 weight % SLS, based on a total weight of the oral care composition;

from about 1.0 weight % to about 2.0 weight % anhydrous cocamidopropyl betaine, based on the total weight of the oral care composition; and

from about 3.0 weight % to about 8.0 weight % of the PEG/PPG copolymer, based on the total weight of the oral care composition.

6. The oral care composition of claim 1, wherein the catalyzing enzyme has perhydrolytic activity and is capable of generating peracetic acid via enzyme-catalyzed perhydrolysis.

7. The oral care composition of claim 1, wherein the source of hydrogen peroxide is a cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex.

8. The oral care composition of claim 1, wherein the anhydrous matrix is substantially free of water.

9. The oral care composition of claims 1, wherein the acyl donor is one or more of a C2-18 carboxylic acid, a hydrolysable ester, and mixtures thereof.

10. The oral care composition of claims 1, wherein the acyl donor is triacetin.

11. The oral care composition of claim 1, further comprising a thickener, wherein the thickener comprises a cross-linked polyvinylpyrrolidone.

12. The oral care composition of claim 11, wherein the thickener further comprises a silica thickener.

13. The oral care composition of claim 1, wherein the catalyzing enzyme comprises a CE-7 signature motif that aligns with SEQ ID NO: 2, the CE-7 signature motif comprising a) an RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2; b) a GXSQG (SEQ ID NO: 3) motif at positions corresponding to positions 179-183 of SEQ ID NO: 2 and an HE motif at positions corresponding to positions 298-299 of SEQ ID NO:2.

14. The oral care composition of claim 1, wherein the catalyzing enzyme comprises an amino acid sequence comprising a CE-7 signature motif and having at least 80% amino acid sequence identity to SEQ ID NO:1.

15. The oral care composition of claim 1, wherein the non-aqueous anhydrous liquid comprises a polyethylene oxide-polypropylene oxide block copolymer having a molecular weight of 5,000 Daltons or less.

16. The oral care composition of claim 15, wherein the non-aqueous anhydrous liquid comprises poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).

17. The oral care composition of claim 1, wherein the catalyzing enzyme comprises

SEQ ID NO: 1.

18. A method for whitening teeth, comprising contacting the oral care composition of claim 1 with water on a surface of the teeth, wherein contacting the oral care composition with water on the surface of the teeth generates peracetic acid.