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1. WO2013153220 - MICROCAPSULES CONTAINING AN OXIDIZABLE ACTIVE, AND A PROCESS FOR PREPARING THE SAME

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[ EN ]

CLAIMS

1. Microcapsule consisting in or containing:

• a core consisting in or comprising an oxidizable active (OA), the outer part of said core being in a solid form, and

• a water insoluble coating obtained from an encapsulating agent (EA), said coating surrounding said core,

in particular, a microcapsule wherein said EA is water soluble, or a microcapsule wherein said EA is an agent, the water solubility of which is pH-dependent,

with the proviso that:

- said core does not consist in or comprise a metal oxide, and

- said coating does not comprise a disintegrant, in particular sodium starch glycolate.

2. Microcapsule according to claim 1, wherein said water insoluble coating results from the reaction of a water soluble EA with means for inducing water insolubility of said EA, in particular:

• a microcapsule wherein said means for inducing water insolubility are an agent chemically reacting with said EA, or

• a microcapsule wherein said means for inducing water insolubility are an acid, a base, or a buffer, or

• a microcapsule wherein said means for inducing water insolubility consist in the drying of said EA.

3. Microcapsule according to anyone of claims 1 and 2, wherein said coating is such that, when said microcapsule is placed in an alimentary, cosmetically or pharmaceutically acceptable medium:

• said OA is not degraded by element(s) of said medium, and

• said element(s) of the medium is (are) not degraded by said OA.

4. Microcapsule according to anyone of claims 1 to 3, wherein the mass of said coating is within the range from 3 to 50%, preferably from 4 to 12%, more preferably from 5 to 8%, of the total mass of said microcapsule.

5. Microcapsule according to anyone of claims 1 to 4, wherein said microcapsule size is in range from 1 μιη to 3mm, preferably from 20 to 500μιη, more preferably from 50 to 200 μιη.

6. Microcapsule according to anyone of claims 1 to 5, wherein said OA is in a crystalline state, in particular a microcapsule wherein said core consists in or comprises an OA in a crystalline state and at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents.

7. Microcapsule according to anyone of claims 1 to 5, wherein said OA is in an amorphous state, in particular a microcapsule wherein said core consists in or comprises an OA in an amorphous state and at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents.

8. Microcapsule according to anyone of claims 1 to 7, wherein said water soluble EA is selected from alginates of monovalent cations, in particular Na+ alginates and K+ alginates.

in particular, wherein said EA is water soluble and selected from alginates of monovalent cations, more particularly Na+ alginates and K+ alginates, and wherein said means for inducing water insolubility are a salt wherein the cation is a divalent metallic cation, more particularly Ca2+ or Mg2+, said salt being in particular CaCl2 or MgCl2.

9. Microcapsule according to anyone of claims 1 to 8, wherein said OA:

• is selected from the group comprising vitamin B5, vitamin B6, vitamin B8, vitamin

B9, vitamin A, vitamin D3, vitamin K, vitamin E and vitamin C, in particular natural vitamin C, synthetic vitamin C, or salts of L-ascorbic acid, more particularly sodium

L-ascorbate, calcium L-ascorbate and iron L-ascorbate, or

• comprises vitamin C, said OA being in particular a fruit juice comprising vitamin C, in particular orange juice, kiwi juice, cranberry juice or acerola juice, said fruit juice being optionally concentrated or dried.

10. Microcapsule according to anyone of claims 1 to 9, wherein said OA is vitamin C or comprises vitamin C and wherein said EA is water soluble and selected from alginates of monovalent cations, in particular Na+ alginates and K+ alginates,

in particular a microcapsule wherein said OA is vitamin C or comprised vitamin C, wherein said EA is water soluble and selected from alginates of monovalent cations, in particular Na+ alginates and K+ alginates, and wherein said means for inducing water insolubility are a salt wherein the cation is a divalent metallic cation, in particular Ca2+ or Mg2+, said salt being in particular CaCl2 or MgCl2.

11. Process of preparation of microcapsules according to anyone of claims 1 to 10, comprising the following steps:

o spray-drying a liquid mixture consisting in or comprising:

• said OA;

• optionally said EA;

• optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents;

to obtain particles consisting in said OA, or particles comprising said OA, and said EA and/or at least one additional element, the outer part of said particles being in a solid form,

o spraying on said particles an insoluble EA or means for inducing water insolubility of EA comprised in said particle, to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core consisting in said OA, or comprising said OA, and said EA and/or at least one additional element,

with the proviso that:

- said core does not consist in or comprise a metal oxide, and

- said coating does not comprise a disintegrant, in particular sodium starch glycolate.

12. Process according to claim 11 comprising, after said spray-drying and spraying steps, a step of drying said microcapsules to obtain dried microcapsules.

13. Process according to claim 12, wherein said spray-drying step, spraying step and drying step are done in a spray-dryer.

14. Process of preparation of microcapsules according to anyone of claims 11 to 13, comprising the following steps:

o spray-drying a liquid mixture consisting in or comprising:

• said OA;

• optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents;

to obtain particles consisting in said OA, or particles comprising said OA and said at least one additional element,

o spraying on said particles a water insoluble EA, to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core consisting in said OA, or comprising said OA and said at least one additional element.

15. Process of preparation of microcapsules according to anyone of claims 11 to 13, comprising the following steps:

o spray-drying a liquid mixture consisting in or comprising:

• said OA;

• a water soluble EA;

• optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents;

to obtain particles comprising said OA, said EA and optionally said at least one additional element,

o spraying on said particles means for inducing water insolubility of EA comprised in said particle, to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core comprising said OA, said EA and optionally at least one additional element.

16. Process of preparation of microcapsules according to anyone of claims 1 to 10, comprising a step of spraying on particles consisting in said OA, or particles comprising said OA, and said EA and/or at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents, an insoluble EA or means for inducing water insolubility of EA comprised in said particle, to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core consisting in said OA, or comprising said OA, and said EA and/or at least one additional element.

17. Process according to claim 16, comprising a step of spraying on particles consisting in said OA, or particles comprising said OA and at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents, a water insoluble coating to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core consisting in said OA, or comprising said OA, and said at least one additional element.

18. Process according to claim 16, comprising in a device a step of spraying on particles comprising:

• said OA,

• a water soluble EA, and

• optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents,

means for inducing water insolubility of EA comprised in said particle, to obtain microcapsules with a water insoluble coating, said water insoluble coating surrounding a core comprising said OA, and said EA and/or at least one additional element,

in particular:

a process wherein said particles are obtained by coating said OA in a solid state with said water soluble EA and optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents, or

a process wherein said particles are obtained in a spray-dryer by co-spraying a homogenous aqueous solution comprising:

· said water soluble EA,

• optionally at least one additional element selected among drying agents, antioxidant agents, filmogen agents and emulsifying agents;

and said OA in a solid state.

19. Process according to claim 18, wherein said spraying of said means for inducing water insolubility of EA is performed in the spray-dryer used to obtain said particles.

20. Food composition comprising microcapsules according to anyone of claims 1 to 10, provided said food composition is not a fermented dairy food composition.