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1. (WO2014165990) SYSTEM AND METHOD FOR IMAGING BIOMARKERS INDICATIVE OF CARDIAC THERMAL ABLATION LESIONS
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

CLAIMS

1. A method for imaging a biomarker indicative of thermal ablation using a medical imaging system, the steps of the method comprising:

a] acquiring data with the medical imaging system; and

b] producing from the acquired data, an image that depicts a biomarker indicative of a thermal ablation.

2. The method as recited in claim 1 in which the biomarker is a physical property of a chemical compound produced in response to thermal ablation.

3. The method as recited in claim 2 in which the chemical compound is at least one of a ferric iron containing chemical compound and a denatured protein.

4. The method as recited in claim 3 in which the ferric iron containing chemical compound is selected from the group consisting of methemoglobin, metmyoglobin, and combinations thereof.

5. The method as recited in claim 1 in which step a] is performed at least one of during a thermal ablation procedure and after a thermal ablation procedure.

6. The method as recited in claim 1 in which the medical imaging system is a magnetic resonance imaging system.

7. The method as recited in claim 6 in which the biomarker is a physical property of a chemical compound produced in response to thermal ablation, and the chemical compound is at least one of a ferric iron containing chemical compound and a denatured protein.

8. The method as recited in claim 7 in which the ferric iron containing chemical compound is selected from the group consisting of methemoglobin, metmyoglobin, and combinations thereof.

9. The method as recited in claim 7 in which the physical property is at least one of a longitudinal magnetization, M0 ; a longitudinal relaxation time, Tx ; a transverse relaxation time, T2 ; and a relaxation time that accounts for both longitudinal and

transverse relaxation, J| .

10. The method as recited in claim 9 in which step b] includes producing a T2 map having pixel values indicative of T2 values.

11. The method as recited in claim 9 in which step b] includes producing a T*

map having pixel values indicative of 7[ values.

12. The method as recited in claim 9 in which step b] includes producing a Zj map having pixel values indicative of Zj values.

13. The method as recited in claim 12 further comprising identifying a thermal ablation lesion in the Jj map and quantifying an age of the identified thermal ablation lesion based on Zj values at pixels locations associated with the identified thermal lesion.

14. The method as recited in claim 6 further comprising monitoring lesion formation in real-time during a cardiac thermal ablation procedure by repeatedly performing steps a] and b] using an inversion-recovery steady-state free precession pulse sequence in step a] to acquire data in a single heartbeat.

15. The method as recited in claim 1 in which the medical imaging system is an intravascular optical imaging system capable of at least one of diffuse reflectance spectroscopy, diffuse optical spectroscopy, and Raman spectroscopy.

16. The method as recited in claim 1 in which the medical imaging system is a photoacoustic imaging system.