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International application No. Applicant's or agent's file reference
PCT/IB2019/061304 618078-SA9-240PC
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
23 December 2019 24 December 2018
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No.     7    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     C07K 16/24 (2006.01)i; C07K 16/28 (2006.01)i; C07K 16/32 (2006.01)i; C07K 16/46 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, EMBASE, BIOSIS, Sequence Search, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2011117653 A1 (UCB PHARMA SA [BE]; HEYWOOD SAM PHILIP [GB]; HUMPHREYS DAVID PAUL [GB]) 29 September 2011 (2011-09-29)
page 2; claim 1
SCHMIEDL A ET AL, "Expression of a bispecific dsFv-dsFv' antibody fragment in Escherichia coli", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB,Vol. 13, No. 10, 01 October 2000 (2000-10-01), page 725-734,
figure 7
WO 0177342 A1 (GENENTECH INC [US]) 18 October 2001 (2001-10-18)
figure 23B
WO 0202781 A1 (VLAAMS INTERUNIV INST BIOTECH [BE]; MERTENS NICO [BE] ET AL.) 10 January 2002 (2002-01-10)
figure 1
BRINKMANN U ED - ROLAND KONTERMANN AND STEFAN DÜBEL, "Antibody Engineering, Chapter 14: Disulfide-Stabilized Fv Fragments", 30 April 2010 (2010-04-30), ANTIBODY ENGINEERING, SPRINGER-VERLAG, BERLIN/HEIDELBERG, DE, PAGE(S) 181 - 189,
ISBN: 9783642011467
figure 14.3
ULRICH BRINKMANN ET AL, "The making of bispecific antibodies", MABS,Vol. 9, No. 2, 10 January 2017 (2017-01-10), page 182-212,
figure 2
HONGCHENG LIU ET AL, "Disulfide bond structures of IgG molecules", MABS,Vol. 4, No. 1, 01 January 2012 (2012-01-01), page 17-23,
figure 1
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2011117653 A1
29 September 2011
EP 2550297 A1
ES 2717883 T3
TR 201903279 T4
US 2013302336 A1
WO 2011117653 A1
30 January 2013
26 June 2019
21 March 2019
14 November 2013
29 September 2011
WO 0177342 A1
18 October 2001
AU 4761601 A
BR 0110610 A
CA 2403425 A1
CN 1464908 A
CN 101289511 A
CY 1119291 T1
DK 1272647 T3
DK 2857516 T3
EP 1272647 A1
EP 2857516 A1
ES 2528794 T3
ES 2637801 T3
HK 1208705 A1
HU 0300369 A2
IL 151853 A
JP 2003531588 A
KR 20020093029 A
LT 2857516 T
MX PA02010011 A
NZ 521540 A
PL 357939 A1
PT 2857516 T
SI 2857516 T1
US 2002004587 A1
US 2006025576 A1
US 2008299120 A1
US 2011110852 A1
US 2012238728 A1
US 2014322221 A1
WO 0177342 A1
ZA 200207589 B
23 October 2001
29 April 2003
18 October 2001
31 December 2003
22 October 2008
14 February 2018
15 December 2014
07 August 2017
08 January 2003
08 April 2015
12 February 2015
17 October 2017
11 March 2016
28 June 2003
01 September 2009
28 October 2003
12 December 2002
11 September 2017
25 April 2003
24 September 2004
09 August 2004
28 August 2017
29 September 2017
10 January 2002
02 February 2006
04 December 2008
12 May 2011
20 September 2012
30 October 2014
18 October 2001
22 September 2003
WO 0202781 A1
10 January 2002
AU 7060901 A
CA 2410551 A1
EP 1294904 A1
US 2004220388 A1
WO 0202781 A1
14 January 2002
10 January 2002
26 March 2003
04 November 2004
10 January 2002
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
18 May 2020
Date of mailing of the international search report:
03 June 2020
Authorized officer:
Saame, Tina
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