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1. WO2009007996 - CYCLODEXTRIN COMPLEXES OF ATOVAQUONE

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[ EN ]

We claim:
1. An inclusion complex of Atovaquone or its pharmaceutically acceptable salts and cyclodextrin or its derivatives, wherein the molar ratio of atovaquone to cyclodextrin in the inclusion complex ranges from about 1 :2 to about 1 :5.
2. An inclusion complex of Atovaquone as in claim 1, wherein the said cyclodextrin is selected from the group consisting of alpha-cyclodextrin, beta-cyclodextrin, gamma- cyclodextrin and their derivatives.
3. An inclusion complex of atovaquone as in claim 1 , wherein the inclusion complex is in a powder form.
4. An inclusion complex as in claim 1 , wherein the complex is prepared by dissolving cyclodextrin, atovaquone in an aqueous medium comprising a volatile amine, and drying.

5. An inclusion complex as in claim 1, wherein the complex is prepared by dissolving cyclodextrin, atovaquone in an aqueous medium comprising a water miscible organic solvent and a volatile amine, and drying.
6. The process as in claim 4 or 5, wherein the volatile amine is ammonia.
7. The process as in claim 5, wherein the water miscible organic solvent is 2-propanol.

8. The process as in claim 4 or 5, wherein the drying is carried out by flash evaporation, spray drying or by freeze drying.
9. A pharmaceutical composition of atovaquone comprising an inclusion complex of atovaquone-cyclodextrin as in claim 1 and pharmaceutically acceptable excipients, wherein the pharmaceutical composition is suitable for oral administration.
10. A pharmaceutical composition as in claim 9, wherein the composition is in the form of granules, pellets, tablets, capsules, sachets, suspensions, solutions suitable for oral
administration.