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1. WO2021205383 - MONOCLONAL ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR SUPPRESSING CD73 IMMUNE CHECKPOINT AND USES THEREOF

Publication Number WO/2021/205383
Publication Date 14.10.2021
International Application No. PCT/IB2021/052934
International Filing Date 09.04.2021
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 15/85 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • APRILBIO CO., LTD. [KR]/[KR]
Inventors
  • CHA, Sang Hoon
Priority Data
10-2020-004360709.04.2020KR
10-2020-014459502.11.2020KR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR SUPPRESSING CD73 IMMUNE CHECKPOINT AND USES THEREOF
(FR) ANTICORPS MONOCLONAUX ET LEURS FRAGMENTS DE LIAISON À L'ANTIGÈNE POUR SUPPRIMER LE POINT DE CONTRÔLE IMMUNITAIRE CD73 ET LEURS UTILISATIONS
Abstract
(EN)
Provided are monoclonal antibodies and antigen binding fragments thereof for suppressing a CD73 immune checkpoint, and uses thereof, wherein the antibodies or antigen binding fragments thereof can bind to CD73, reduce enzymatic activity of CD73 protein, and inhibit cancer metastasis or cancer growth, thus enabling uses thereof as therapeutic agents for cancer.
(FR)
L'invention concerne des anticorps monoclonaux et des fragments de liaison à l'antigène de ceux-ci pour supprimer un point de contrôle immunitaire CD73, et leurs utilisations, les anticorps ou les fragments de liaison à l'antigène de ceux-ci pouvant se lier à CD73, réduire l'activité enzymatique de la protéine CD73, et inhiber la métastase cancéreuse ou la croissance du cancer, ce qui permet de les utiliser en tant qu'agents thérapeutiques pour le cancer.
Latest bibliographic data on file with the International Bureau