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1. WO2021204936 - APPARATUS AND METHOD FOR BIOMARKER DETECTION

Publication Number WO/2021/204936
Publication Date 14.10.2021
International Application No. PCT/EP2021/059158
International Filing Date 08.04.2021
IPC
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 27/414 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
403Cells and electrode assemblies
414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
B01L 3/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
C12Q 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
Applicants
  • THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW [GB]/[GB]
Inventors
  • CUMMING, David Robert Sime
  • ANNESE, Valerio Francesco
Agents
  • MEWBURN ELLIS LLP
Priority Data
2005170.208.04.2020GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) APPARATUS AND METHOD FOR BIOMARKER DETECTION
(FR) APPAREIL ET PROCÉDÉ DE DÉTECTION DE BIOMARQUEURS
Abstract
(EN)
A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.
(FR)
L'invention concerne un appareil de détection de biomarqueurs dans lequel une puce à base de CMOS est utilisée pour générer des signaux de détection indépendants à partir d'une zone de réaction qui reçoit un échantillon biologique, l'échantillon biologique étant fourni à la fois à une région de test et à des régions de contrôle positif et négatif dans la zone de réaction. Les signaux de détection indépendants peuvent être traités ensemble (c.-à-d. comme un groupe de paramètres d'entrée pour un algorithme) pour identifier la présence d'un biomarqueur (ou d'une pluralité de biomarqueurs) dans un échantillon biologique. L'utilisation de témoins positifs et négatifs détectables indépendamment et propres à chaque échantillon permet d'améliorer la précision de la détection.
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