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1. WO2021204858 - METHOD FOR QUANTITATIVE IMAGING OF THE METABOLIC STATUS OF A LESION

Publication Number WO/2021/204858
Publication Date 14.10.2021
International Application No. PCT/EP2021/059034
International Filing Date 07.04.2021
IPC
A61B 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
G01N 21/64 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 33/573 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
Applicants
  • HUMANITAS MIRASOLE S.P.A. [IT]/[IT]
Inventors
  • DONI, Andrea
  • MORONE, Diego
Agents
  • BANFI, Paolo
Priority Data
20169219.110.04.2020EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR QUANTITATIVE IMAGING OF THE METABOLIC STATUS OF A LESION
(FR) PROCÉDÉ D'IMAGERIE QUANTITATIVE DE L'ÉTAT MÉTABOLIQUE D'UNE LÉSION
Abstract
(EN)
This invention pertains to a fluorescence lifetime imaging microscopy (FLIM) - based method for the quantitative three-dimensional (3D) imaging of the metabolic status of a lesion, comprising the acquisition of FLIM data of a least one anaerobic glycolysis marker. This method applies in particular to lesions such as wounds and tumours, and to markers such as the NADH/NAD+ ratio, the NAD(P)H/NAD+ ratio, the NADH/FAD ratio, the NAD(P)H/FAD ratio or the FADH/FAD ratio as a first marker, and their optional combination with a second marker such as pH, oxygen tension, glucose, pyruvate and lactate.
(FR)
La présente invention concerne un procédé fondé sur une microscopie d'imagerie par durée de vie de fluorescence (FLIM) pour l'imagerie quantitative en trois dimensions (3D) de l'état métabolique d'une lésion, consistant à acquérir des données FLIM d'au moins un marqueur de la glycolyse anaérobie. Ce procédé s'applique en particulier à des lésions telles que des plaies et des tumeurs, et à des marqueurs tels que le rapport NADH/NAD+, le rapport NAD(P)H/NAD+, le rapport NADH/FAD, le rapport NAD(P)H/FAD ou le rapport FADH/FAD en tant que premier marqueur, et leur combinaison éventuelle avec un second marqueur tel que le pH, la tension en oxygène, le glucose, le pyruvate et le lactate.
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