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1. WO2023008974 - DUAL FUNCTIONAL COSMETIC COMPOSITIONS AND PREPARATION METHOD THEREFOR

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Publication Number WO/2023/008974
Publication Date 02.02.2023
International Application No. PCT/KR2022/011256
International Filing Date 29.07.2022
IPC
C07K 14/50 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
50Fibroblast growth factor (FGF)
C07K 14/485 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
485Epidermal growth factor (EGF) (urogastrone)
A61K 8/64 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61Q 19/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
CPC
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
C07K 14/485
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
485Epidermal growth factor [EGF] (urogastrone)
C07K 14/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
50Fibroblast growth factors [FGF]
C07K 2319/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
31fusions, other than Fc, for prolonged plasma life, e.g. albumin
Applicants
  • 주식회사 유비프로틴 UBIPROTEIN CORP [KR]/[KR]
Inventors
  • 김명선 KIM, Myung-Sun
  • 오수경 OH, Su Kyung
  • 김경곤 KIM, Kyunggon
  • 백광현 BAEK, Kwang-Hyun
  • 배성렬 BAE, Sung-Ryul
Agents
  • 이종승 LEE, Jong Seung
Priority Data
10-2021-010005929.07.2021KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) DUAL FUNCTIONAL COSMETIC COMPOSITIONS AND PREPARATION METHOD THEREFOR
(FR) COMPOSITIONS COSMÉTIQUES À DOUBLE FONCTION ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(KO) 이중 기능성 화장료 조성물 및 이의 제조방법
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Abstract
(EN) The present invention relates to a method for extending a half-life of a protein, the method comprising substituting one lysine residue in each of the amino acid sequences in two proteins, or to a protein having an extended half-life. The protein in which lysine residues have been substituted according to the present invention persists in the body for an extended period of time, and exhibits excellent treatment results. In addition, two kinds of proteins can be produced and provided in a single production process.
(FR) La présente invention se rapporte à un procédé destiné à augmenter la demi-vie d’une protéine, le procédé consistant à remplacer un résidu de lysine dans chacune des séquences d’acides aminés par deux protéines, ou une protéine ayant une demi-vie prolongée. La protéine dans laquelle les résidus de lysine ont été remplacés selon la présente invention se maintient dans l’organisme pendant un long laps de temps et présente d’excellents résultats de traitement. En outre, deux types de protéines peuvent être produites et fournies dans le cadre d’un procédé de production unique.
(KO) 본 발명은 2종의 단백질 아미노산 서열에 존재하는 하나씩의 라이신 잔기를 치환 하는 것을 포함하여 단백질의 반감기를 증가시키는 방법 또는 반감기가 증가 된 단백질에 관한 것으로서, 본 발명의 라이신 잔기가 치환된 단백질은 인체 내에 서 오랜 시간 동안 잔류하며 치료효과가 우수하다. 또한 한 번의 생산 과정으로 2종의 단백질을 생산 제공할 수 있다.
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