(EN) The application relates to antiviral compositions comprising andrographolide, ursolic acid, and piceid and their use in treatment of viral and bacterial infections (including COVID-19). Combinations of either andrographolide and ursolic acid, or andrographolide and piced are also disclosed. Alternatively, extracts from Andrographis paniculata(for andrographolide), Eriobotrya japonica (for ursolic acid), and Reynoutria japonica (piceid) are used. The combination can additionally comprise other antivirals including monoclonal antibodies.