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1. WO2015095792 - CARBAMATE BENZOXAXINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORGAMMA ACTIVITY AND THE TREATMENT OF DISEASE

Publication Number WO/2015/095792
Publication Date 25.06.2015
International Application No. PCT/US2014/071663
International Filing Date 19.12.2014
IPC
A61K 31/5375 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
CPC
A61K 31/538
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
538ortho- or peri-condensed with carbocyclic ring systems
C07D 265/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
34condensed with carbocyclic rings
36condensed with one six-membered ring
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • LYCERA CORPORATION [US]/[US]
Inventors
  • AICHER, Thomas D.
  • VAN HUIS, Chad A.
  • MACLEAN, John K.
  • ANDRESEN, Brian M.
  • BARR, Kenneth J.
  • BIENSTOCK, Corey E.
  • DANIELS, Matthew
  • LIU, Kun
  • LIU, Yuan
  • WHITE, Catherine M.
  • SCIAMMETTA, Nunzio
  • SIMOV, Vladimir
Agents
  • DAVIS, Chad E.
Priority Data
61/918,94820.12.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CARBAMATE BENZOXAXINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORGAMMA ACTIVITY AND THE TREATMENT OF DISEASE
(FR) ACIDES PROPIONIQUES DE CARBAMATE BENZOXAZINE ET DÉRIVÉS ACIDES POUR LA MODULATION DE L'ACTIVITÉ DE RORGAMMA ET LE TRAITEMENT DE MALADIE
Abstract
(EN) The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
(FR) La présente invention concerne certains composés de benzoxazine représentés par la formule (I) ou leurs sels pharmaceutiquement acceptables, dans laquelle R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, et Cy sont tels que définis ici. L'invention concerne également des compositions pharmaceutiques comprenant ces composés de formule (I) ou leurs sels pharmaceutiquement acceptables et des procédés d'utilisation des composés de formule (I) ou de leurs sels pharmaceutiquement acceptables ou de compositions pharmaceutiques les comprenant pour le traitement de maladies ou d'affections médiées par RORgammaT.
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