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1. WO2021080013 - INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION

Publication Number WO/2021/080013
Publication Date 29.04.2021
International Application No. PCT/JP2020/039994
International Filing Date 23.10.2020
IPC
A61P 21/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 21/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
02Muscle relaxants, e.g. for tetanus or cramps
A61P 25/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
Applicants
  • ONO PHARMACEUTICAL CO., LTD. [JP]/[JP]
  • VANDERBILT UNIVERSITY [US]/[US]
Inventors
  • LINDSLEY, Craig W
  • ENGERS, Darren W
  • CHILDRESS, Elizabeth S
  • BOLLINGER, Sean R
  • SCHMITT, Joza
  • CHOPKO, Trevor C
  • DENTON, Jerod S
  • TANAKA, Motoyuki
  • KURATA, Haruto
Agents
  • AOKI, Atsushi
  • MITSUHASHI, Shinji
  • WATANABE, Yoichi
  • NAKAJIMA, Masaru
  • TAKEI, Ryotaro
  • NAKAMURA, Kazumi
Priority Data
62/925,47524.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION
(FR) INHIBITEURS DE LA FONCTION DES CANAUX TREK (CANAUX K+ ASSOCIÉS À TWIK)
Abstract
(EN)
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds and methods of using the compounds to treat disorders associated with dysregulation of TREK-1, TREK-2 or both TREK-1 and TREK-2 in a mammal.
(FR)
L'invention concerne un composé de formule (I) : dans laquelle tous les symboles sont définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés, des procédés de fabrication des composés, des kits comprenant les composés et des procédés d'utilisation des composés pour traiter des troubles associés à un dérèglement de TREK-1, TREK-2 ou à la fois de TREK-1 et de TREK-2 chez un mammifère.
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