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1. WO2009012005 - PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION

Publication Number WO/2009/012005
Publication Date 22.01.2009
International Application No. PCT/US2008/067058
International Filing Date 16.06.2008
IPC
C07D 489/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro furan ring systems, e.g. derivatives of -morphinan of the formula:
02with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07D 489/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro furan ring systems, e.g. derivatives of -morphinan of the formula:
06with a hetero atom directly attached in position 14
08Oxygen atom
CPC
C07D 489/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
02with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07D 489/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
06with a hetero atom directly attached in position 14
08Oxygen atom
Applicants
  • MALLINCKRODT INC. [US]/[US] (AllExceptUS)
  • GROTE, Christopher, W. [US]/[US] (UsOnly)
  • ORR, Brian [GB]/[US] (UsOnly)
  • JIANG, Tao [CN]/[US] (UsOnly)
  • CANTRELL, Gary, L. [US]/[US] (UsOnly)
Inventors
  • GROTE, Christopher, W.
  • ORR, Brian
  • JIANG, Tao
  • CANTRELL, Gary, L.
Agents
  • SIMAN, Craig, D.
Priority Data
60/950,12717.07.2007US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION
(FR) PRÉPARATION D'OPIACÉS N-ALKYLÉS PAR AMINATION RÉDUCTRICE
Abstract
(EN) The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
(FR) L'invention concerne la réduction d'un groupe N-imine ou d'un groupe hémiaminal d'un morphinane en présence d'un catalyseur asymétrique au ruthénium, au rhodium, ou à l'iridium et d'une source d'hydrogène.
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