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1. IN286/CHENP/2010 - PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION

Office
India
Application Number 286/CHENP/2010
Application Date 15.01.2010
Publication Number 286/CHENP/2010
Publication Date 16.07.2010
Publication Kind A
IPC
C07D 48/02
Applicants MALLINCKRODT INC
Inventors GROTE, CHRISTOPHER, W
ORR, BRIAN
JIANG, TAO
CANTRELL, GARY, L
Priority Data 60/950,127 17.07.2007 US
Title
(EN) PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION
Abstract
(EN) The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.