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1. WO2004035572 - N-{2-CHLORO-4-[(6,7-DIMETHOXY-4-QUINOLYL)OXY]PHENYL}-N’-(5-METHYL-3-ISOXAZOLYL)UREA SALT IN CRYSTALLINE FORM

Publication Number WO/2004/035572
Publication Date 29.04.2004
International Application No. PCT/JP2003/013439
International Filing Date 21.10.2003
Chapter 2 Demand Filed 25.02.2004
IPC
A61K 31/4709 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
CPC
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • KIRIN BEER KABUSHIKI KAISHA [JP]/[JP] (AllExceptUS)
  • MATSUNAGA, Naoki [JP]/[JP] (UsOnly)
  • YOSHIDA, Satoshi [JP]/[JP] (UsOnly)
  • YOSHINO, Ayako [JP]/[JP] (UsOnly)
  • NAKAJIMA, Tatsuo [JP]/[JP] (UsOnly)
Inventors
  • MATSUNAGA, Naoki
  • YOSHIDA, Satoshi
  • YOSHINO, Ayako
  • NAKAJIMA, Tatsuo
Agents
  • YOSHITAKE, Kenji
Priority Data
2002-30610121.10.2002JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) N-{2-CHLORO-4-[(6,7-DIMETHOXY-4-QUINOLYL)OXY]PHENYL}-N’-(5-METHYL-3-ISOXAZOLYL)UREA SALT IN CRYSTALLINE FORM
(FR) SEL DE N-{2-CHLORO-4-[(6,7-DIMETHOXY-4-QUINOLYL)OXY]PHENYL}-N'-(5-METHYL-3-ISOXAZOLYL)UREE SOUS FORME CRISTALLINE
(JA) N−{2−クロロ−4−[(6,7−ジメトキシ−4−キノリル)オキシ]フェニル}−N’−(5−メチル−3−イソキサゾリル)ウレアの塩の結晶形
Abstract
(EN) It is intended to provide crystals of a pharmaceutically acceptable salt of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N’-(5-methyl-3-isoxazolyl)urea. The salt crystals are used in treating a disease selected from the group consisting of tumor, diabetic retinopathy, rheumatoid arthritis, psoriasis, atheroma arteriosclerosis, Kaposi’s sarcoma and exudative age-related macular degeneration. The salt crystals have properties appropriate for preparations for oral administration.
(FR) L'invention concerne des cristaux d'un sel pharmaceutiquement acceptable de N-{2-chloro-4-[(6,7-diméthoxy-4-quinolyl)oxy]phényl}-N'-(5-méthyl-3-isoxazolyl)urée. Ces cristaux de sel s'utilisent dans le traitement d'une maladie sélectionnée dans le groupe constitué par des tumeurs, la rétinopathie diabétique, la polyarthrite rhumatoïde, le psoriasis, l'artériosclérose, le sarcome de Kaposi et la dégénérescence maculaire exsudative liée à l'âge. Lesdits cristaux de sel présentent des propriétés convenant pour des préparations s'administrant par voie orale.
(JA) 本発明によれば、N−{2−クロロ−4−[(6,7−ジメトキシ−4−キノリル)オキシ]フェニル}−N’−(5−メチル−3−イソキサゾリル)ウレアの医薬上許容される塩の結晶が提供される。この塩の結晶は、腫瘍、糖尿病性網膜症、慢性関節リウマチ、乾癬、アテローム性動脈硬化症、カポジ肉腫、および滲出型加齢黄斑性症からなる群より選択される疾患の治療に用いられる。この塩の結晶は、経口医薬製剤の用途に好適な特性を有する。
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