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1. WO2020139598 - ORAL CARE COMPOSITIONS AND METHODS OF USE

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[ EN ]

Claims:

1. A method of treatment or prophylaxis of a disease or disorder related to an oral and/or systemic bacterial infection consequent to promulgation of orally-derived bacteria, the method comprising the administration of an oral care composition comprising a basic amino acid in free or salt from; at least one zinc ion source.

2. The method according to claim 1, wherein the disease or disorder related to oral and/or systemic bacterial infection consequent to the accumulation of biofilms involving Gram negative bacterial interaction with Gram-positive bacteria.

3. The method according to claims 1 or 2, wherein the disease or disorder is gum disease, endocarditis, cardiovascular disease, bacterial pneumonia, diabetes mellitus, hardening of the aortic arch, circulatory deficiencies consequent to hardening of the aortic arch, increased blood pressures consequent to hardening of the aortic arch, and low birth weight.

4. A method according to any of the preceding claims, wherein the disease or disorder is gum disease, endocarditis, cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight.

5. A method according to any of the preceding claims, wherein the disease or disorder is gum disease or endocarditis.

6. A method according to any of the preceding claims, wherein the disease or disorder is endocarditis.

7. A method according to any of the preceding claims, wherein the disease or disorder is promulgated via transient bacteremia, metastatic injury from the effects of circulating oral microbial toxins, or metastatic inflammation caused by immunological injury induced by oral microorganisms.

8. A method according to any of the preceding claims, wherein the disease or disorder is endocarditis promulgated via transient bacteremia metastatic injury from the effects of circulating oral microbial toxins, or metastatic inflammation caused by immunological injury induced by periodontal pathogens interaction with primary colonizing oral microorganisms.

9. A method according to any of the preceding claims, wherein the administration comprises brushing and/or rinsing a patient’s teeth with the oral care dentifrice.

10. A method according to any of the preceding claims, wherein the oral care composition is applied to a patient’s teeth once, twice or three times daily.

11. A method according to any of the preceding claims, wherein the basic amino acid is arginine in free or salt form.

12. A method according to any of the preceding claims, wherein the zinc ion source comprises a combination of zinc oxide and zinc citrate.

13. An oral care composition for use in a method of treatment or prophylaxis of a systemic bacterial infection consequent to promulgation of orally-derived bacteria in a subject in need thereof according to any of claims 1-12.

14. An oral care composition in the manufacture of a medicament for the treatment or prophylaxis of a systemic bacterial infection consequent to promulgation of orally- derived bacteria according to any of claims 1-12.