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Machine translation
1. (WO2017196795) BIOACTIVE METABOLITES ENCODED BY THE HUMAN MICROBIOME USING PRIMARY SEQUENCE ALONE
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

CLAIMS

What is claimed is:

1. A composition comprising a peptide, wherein the peptide comprises an amino acid sequence of YSY[Xi]T[X2]V (SEQ ID NO: 1) or any derivative or analog thereof.

2. The composition of claim 1 , wherein the peptide comprises an N-terminal modification.

3. The composition of claim 2, wherein the N-terminal modification comprises an acyl group on the N-terminus of the peptide.

4. The composition of claim 2, wherein the N-terminal modification comprises a fatty acid on the N-terminus of the peptide.

5. The composition of claim 4, wherein the fatty acid is β-hydroxymyristic acid (HMA).

6. The composition of claim 1 , wherein X1 is F or Y.

7. The composition of claim 1 , wherein X2 is V or I.

8. The composition of claim 1 , wherein the peptide comprises an amino acid sequence selected from the group consisting of YSYFTVV (SEQ ID NO: 2) and YSYYTIV (SEQ ID NO: 3).

9. The composition of claim 1 , wherein Y at position 1, S at position 2, Xi at position 4, X2 at position 6, and V at position 7 are in the L configuration.

10. The composition of claim 1 , wherein Y at position 3 and T at position 5 are in the D configuration.

11. The composition of claim 1 , wherein the composition is an antibiotic.

12. The composition of claim 1 1 further comprising a pharmaceutical acceptable carrier.

13. The composition of claim 1 , wherein the peptide is synthetically synthesized.

14. A method of inhibiting proliferation of a bacterial cell, the method comprising administering to the bacterial cell any of the compositions of claims 1 -13.

15. The method of claim 14, wherein the bacterial cell is Gram-positive.

16. The method of claim 14, wherein the bacterial cell is in a mammal.

17. The method of claim 16, wherein the mammal is a human.

18. The method of claim 16, wherein the mammal is a non-human.