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1. WO2021196268 - ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST CORONAVIRUS, AND USE THEREOF

Publication Number WO/2021/196268
Publication Date 07.10.2021
International Application No. PCT/CN2020/084478
International Filing Date 13.04.2020
IPC
C07K 16/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
A61K 39/42 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants
  • 三优生物医药(上海)有限公司 SANYOU BIOPHARMACEUTICALS CO., LTD. [CN]/[CN]
  • 上海之江生物科技股份有限公司 SHANGHAI ZJ BIO-TECH CO., LTD. [CN]/[CN]
Inventors
  • 郎国竣 LANG, Guojun
  • 邵俊斌 SHAO, Junbin
  • 谭永聪 TAN, Yongcong
  • 姚航平 YAO, Hangping
  • 张文海 ZHANG, Wenhai
  • 闫鑫甜 YAN, Xintian
  • 胡宇豪 HU, Yuhao
  • 孔超 KONG, Chao
  • 周蕴华 ZHOU, Yunhua
  • 闫闰 YAN, Run
  • 孙兴鲁 SUN, Xinglu
  • 吴琪 WU, Qi
  • 姚福家 YAO, Fujia
  • 田美 TIAN, Mei
  • 韩晓刚 HAN, Xiaogang
Agents
  • 北京市中咨律师事务所 ZHONGZI LAW OFFICE
Priority Data
202010236256.830.03.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST CORONAVIRUS, AND USE THEREOF
(FR) ANTICORPS AYANT UNE ACTIVITÉ NEUTRALISANTE CONTRE LE CORONAVIRUS, ET UTILISATION ASSOCIÉE
(ZH) 针对冠状病毒的具有中和活性的抗体及其用途
Abstract
(EN) Provided are an antibody or an antigen binding fragment specifically binding to a coronavirus S protein, a multispecific antibody, and an antibody composition. Further provided are a nucleic acid encoding the antibody or the antigen binding fragment, and the multispecific antibody, a host cell comprising the nucleic acid, and a method for preparing the antibody or the antigen binding fragment, and the multispecific antibody. In addition, further provided are prevention, treatment, and/or diagnosis uses of the antibody or the antigen binding fragment, the multispecific antibody, and the antibody composition.
(FR) L'invention concerne un anticorps ou un fragment de liaison à l'antigène se liant spécifiquement à une protéine S de coronavirus, un anticorps multispécifique et une composition d'anticorps. L'invention concerne en outre un acide nucléique codant pour l'anticorps ou le fragment de liaison à l'antigène, et l'anticorps multispécifique, une cellule hôte comprenant l'acide nucléique, et un procédé de préparation de l'anticorps ou du fragment de liaison à l'antigène, et de l'anticorps multispécifique. De plus, l'invention concerne également des utilisations de prévention, de traitement et/ou de diagnostic de l'anticorps ou du fragment de liaison à l'antigène, de l'anticorps multispécifique et de la composition d'anticorps.
(ZH) 提供了特异性结合冠状病毒S蛋白的抗体或抗原结合片段、多特异性抗体、以及抗体组合。还提供了编码抗体或抗原结合片段、多特异性抗体的核酸及包含其的宿主细胞,以及制备抗体或抗原结合片段、多特异性抗体的方法。此外,还提供了抗体或抗原结合片段、多特异性抗体、抗体组合的预防、治疗和/或诊断用途。
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