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1. WO2014081322 - SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES WITH ULTRA-THIN POLYMER LAYERS, THE METHOD OF THEIR PREPARATION AND APPLICATION

Publication Number WO/2014/081322
Publication Date 30.05.2014
International Application No. PCT/PL2013/050031
International Filing Date 19.11.2013
IPC
A61K 49/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 33/26 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
B82Y 5/00 2011.1
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 30/00 2011.1
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
C01G 49/08 2006.1
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F94
49Compounds of iron
02Oxides; Hydroxides
08Ferroso-ferric oxide
CPC
A61K 49/0093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0063characterised by a special physical or galenical form, e.g. emulsions, microspheres
0069the agent being in a particular physical galenical form
0089Particulate, powder, adsorbate, bead, sphere
0091Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
0093Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
A61K 49/1863
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1863the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
B82Y 15/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C01G 49/02
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
49Compounds of iron
02Oxides; Hydroxides
Applicants
  • UNIWERSYTET JAGIELLONSKI
Inventors
  • ZAPOTOCZNY, Szczepan
  • KANIA, Gabriela
  • SZPAK, Agnieszka
  • NOWAKOWSKA, Maria
Agents
  • CZARNIK, Maciej
Priority Data
P.40170621.11.2012PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES WITH ULTRA-THIN POLYMER LAYERS, THE METHOD OF THEIR PREPARATION AND APPLICATION
(FR) NANOPARTICULES D'OXYDE DE FER SUPERPARAMAGNÉTIQUE COMPORTANT DES COUCHES POLYMÈRES ULTRAMINCES, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION
Abstract
(EN)
This invention relates to superparamagnetic iron oxide nanoparticles with ultra-thin polymer layers characterized in that they consist of superparamagnetic iron oxide cores co- precipitated with polycation, and a hydrophilic coating consisting of at least one ultra-thin layer of polyelectrolyte. The invention also provides a method for producing superparamagnetic nanoparticles according to the invention, and the use of superparamagnetic nanoparticles according to the invention as a contrast agent in magnetic resonance imaging and/or fluorescence imaging and/or fluorescence microscopy.
(FR)
La présente invention concerne des nanoparticules d'oxyde de fer superparamagnétique comportant des couches polymères ultraminces. Lesdites particules sont caractérisées en ce qu'elles sont constituées d'un cœur en oxyde de fer superparamagnétique co-précipité avec un polycation, et d'une enveloppe hydrophile constituée d'au moins une couche ultramince de polyélectrolyte. L'invention concerne également un procédé de production de nanoparticules superparamagnétiques selon l'invention et l'utilisation des nanoparticules superparamagnétiques selon l'invention en tant qu'agent de contraste dans l'imagerie par résonance magnétique et/ou l'imagerie par fluorescence et/ou la microscopie de fluorescence.
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