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1. CN113677793 - STABILIZED CRISPR COMPLEXES

Office
China
Application Number 202080028119.3
Application Date 17.07.2020
Publication Number 113677793
Publication Date 19.11.2021
Publication Kind A
IPC
C12N 9/22
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NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
C12N 15/11
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12N 15/88
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using liposome vesicle
C12N 15/85
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
C12P 19/34
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19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C12P 1/20
CPC
C12N 15/113
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
C12N 2310/20
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2310Structure or type of the nucleic acid
10Type of nucleic acid
20involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
102Mutagenizing nucleic acids
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
902using homologous recombination
907in mammalian cells
C12N 9/22
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9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
16acting on ester bonds (3.1)
22Ribonucleases ; RNAses, DNAses
C07F 9/65522
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07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
655having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
6552the oxygen atom being part of a six-membered ring
65522condensed with carbocyclic rings or carbocyclic ring systems
Applicants SYNTHEGO CORP.
辛瑟高公司
Inventors MAURES TRAVIS
特拉维斯·毛雷斯
CARLSON-STEVERMER JARED
贾里德·卡尔森-斯特弗默
JOSHI SAHIL
萨希尔·乔什
KELSO REED
里德·凯尔索
KADINA ANASTASIA
阿纳斯塔西娅·卡迪娜
WALKER JOHN ANDREW II
约翰·安德鲁·沃克二世
Agents 北京安信方达知识产权代理有限公司 11262
北京安信方达知识产权代理有限公司 11262
Priority Data 62/876,177 19.07.2019 US
62/876,204 19.07.2019 US
62/939,553 22.11.2019 US
62/939,554 22.11.2019 US
63/010,465 15.04.2020 US
PCT/US2020/015127 25.01.2020 US
Title
(EN) STABILIZED CRISPR COMPLEXES
(ZH) 稳定的CRISPR复合物
Abstract
(EN) Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to improve the efficacy of target binding and/or cleavage.
(ZH) 本文提供了多核苷酸和CRISPR效应蛋白,所述多核苷酸和CRISPR效应蛋白被配置为以CRISPR复合物的形式共价结合在一起。所述多核苷酸可以被进一步修饰以调节CRISPR复合物的活性。所述多核苷酸和CRISPR效应蛋白的修饰可以用于改进靶结合和/或裂解的效力。
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GB2110535.8This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
EP2020843593This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.