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13. (US20160242718) Voxel-Resolution Myocardial Blood Flow Analysis

Application Number: 15026697 Application Date: 03.10.2014
Publication Number: 20160242718 Publication Date: 25.08.2016
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS1459062 ; Publication Number: Click to see the data
IPC:
A61B 6/00
G06T 7/00
A61B 5/0275
CPC:
A61B 6/507
A61B 5/0044
A61B 5/02755
A61B 6/037
G06T 7/0014
G06T 7/0016
G06T2207/10104
G06T2207/30104
Applicants: HOWARD UNIVERSITY
Inventors: John M. M. Anderson
Priority Data:
Title: (EN) Voxel-Resolution Myocardial Blood Flow Analysis
Abstract:
(EN)

A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS-II) model can be applied, whereby estimating factor curves in the myocardium can be physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS-II model into a discrete-time K-FADS-II model and application of an iterative Improved Voxel-Resolution myocardial blood flow (IV-MBF) algorithm. Where the model is applied without assumption that a right ventricle tissue curve and a left ventricle tissue curve obey a particular mathematical relationship, a least squares objective function can be applied to obtain estimates for parameters of the pharmacological kinetic model by applying a majorize-minimize optimization technique to iteratively estimate the curves.