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1. WO1997023198 - A COSMETIC COMPOSITION AND A METHOD FOR REDUCING THE AGEING PROCESSES OF SKIN

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[ EN ]
Claims

1. A cosmetic composition comprising a hydroximic acid derivative of the formula


wherein
R represents a hydrogen atom or a C-, c alkyl group,
2
R stands for a hydrogen atom, a C,_5 alkyl group, a C-> 8 cycloalkyl group or a phenyl group optionally substituted by a hydroxy or a phenyl group, or
R 1 and R2 together with the nitrogen atom they are attached to form a 5 to 8 membered ring optionally containing one or more further nitrogen, oxygen or sulfur atom(s) and said ring can be condensed with another alicyclic or heterocyclic ring, preferably a benzene, naphthalene, quinoline, isoquinoline, pyridine or pyrazoline ring, furthermore, if desired and chemically possible, the nitrogen and/or sulfur heteroatom(s ) are present in the form of an oxide or dioxide,
R means a hydrogen atom, a phenyl group, a naphthyl group or a pyridyl group wherein said groups can be substituted by one
or more halo atom(s) or C,_4 alkoxy
group(s) ,
Y is a hydrogen atom, a hydroxy group, a
C,_24 alkoxy group optionally substituted by an amino group, a C- 24 polyalkenyloxy group containing 1 to 6 double bond(s), a C-. 2t; alkanoyl group, a C., g alkenoyl group or a group of the formula R -C00- wherein R represents a C2_30 polyalkenyl group containing 1 to 6 double bond(s),

X stands for a halo atom, an amino group, a C-, 4 alkoxy group, or
X forms with B an oxygen atom, or
X and Y together with the carbon atoms they are attached to and the -NR-0-CH2- group being between said carbon atoms form a ring of the formula


wherein
Z represents an oxygen atom or a nitrogen atom,
R stands for a hydrogen atom or
R forms with B a chemical bond, A is a C, . alkylene group or a chemical
bond or a group of the formula


wherein
4
R represents a hydrogen atom, a C, c
alkyl group, a C3_Q cycloalkyl group
or a phenyl group optionally substituted by a halo atom, a C, . alkoxy group
or a C, 5 alkyl group,
R stands for a hydrogen atom, a C, .
alkyl group or a phenyl group,
m has a value of 0, 1 or 2 ,
n has a value of 0, 1 or 2 ,
or a physiologically acceptable acid addition salt thereof as the active ingredient in admixture with one or more conventional carrier (s ) .
2. A cosmetic composition of Claim 1 in which the active ingredient is a compound of the formula

wherein R , R , R , R , R , and n are as stated in Claim 1, X represents a halo atom or an amino group, Y stands for a hydroxy group, or a physiologically acceptable acid addition salt thereof.
3. A cosmetic composition of Claim 1 in which the active ingredient is a compound of the formula

0 OH
II R
R5-A-C-NH-0-CH2-CH-CH2-N R2

wherein R 1 , R2 , R3 and A are as defined in

Claim 1, or a physiologically acceptable acid addition salt thereof.
4. A cosmetic composition of Claim 1 in which the active ingredient is a compound of the formula

wherein R 1 , R2 , R3 and A are as stated in

Claim 1, Z represents an oxygen or a nitrogen atom, or a physiologically acceptable acid addition salt thereof.
5. A cosmetic composition of Claim 1 in which the active ingredient is a compound of the formula


wherein R 1, R2 , R3 and A are as defined in

Claim 1, R represents a C, . alkyl group, or a physiologically acceptable acid addition salt thereof.
6. A cosmetic composition of Claim 1 or 2 in which the active ingredient is a compound of the formula II, wherein R and R together with the nitrogen atom they are attached to form a piperidino group, m and n have the value of 0, X and Y are as stated in Claim 2 , or a physiologically acceptable acid addition salt thereof.
7. A cosmetic composition of Claim 1, 2 or 6 in which the active ingredient is 0-( 3-piperidino-2-hydroxy-1-propyl) pyrid- 3-ylhydroximic acid chloride or a
physiologically acceptable acid addition salt thereof.
8. A cosmetic composition of Claim 1, 2 or 6 in which the active ingredient is

0-( 3-piperidino-2-hydroxy-l-propyl )nicotinic amidoxime or a physiologically acceptable acid addition salt thereof.
9. A cosmetic composition of any of Claims 1 to 8 comprising 0.1 to 30 % by mass of the active ingredient.
10. A method for reducing the ageing processes of skin and/or treating the
pathological lesions of skin in which the affected skin surface is treated with a cosmetically effective non-toxic amount of a hydroximic acid derivative of the formula
1 2 3
I, wherein R, R , R , R , X, Y and B are as defined in Claim 1 , or a physiologically acceptable acid addition salt thereof.
11. A method of Claim 10 in which the skin surface is treated with a cosmetic composition comprising 0.1 to 30 % by mass of a hydroximic acid derivative of the formula
1 2 3
I, wherein R, R , R , R , X, Y and B are as defined in Claim 1 , or a physiologically acceptable acid addition salt thereof.
12. A method of Claim 10 or 11 in which the hydroximic acid derivative is
0- ( 3-piperidino-2-hydroxy-l-propyl )pyrid-3-ylhydroximic acid chloride.
13. A method of Claim 10 or 11 in which the hydroximic acid derivative is
0- ( 3-piperidino-2-hydroxy-l-propyl )nicotinic amidoxi e.