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1. (WO2008039553) SOLUBLE IL-17RCX4 AND METHODS OF USING IN INFLAMMATION

Pub. No.:    WO/2008/039553    International Application No.:    PCT/US2007/061909
Publication Date: Fri Apr 04 01:59:59 CEST 2008 International Filing Date: Sat Feb 10 00:59:59 CET 2007
IPC: C07K 14/15
C07K 16/28
Applicants: ZYMOGENETICS, INC.
KUESTNER, Rolf, E.
GAO, Zeren
LEVIN, Steven, D.
RIXON, Mark, W.
Inventors: KUESTNER, Rolf, E.
GAO, Zeren
LEVIN, Steven, D.
RIXON, Mark, W.
Title: SOLUBLE IL-17RCX4 AND METHODS OF USING IN INFLAMMATION
Abstract:
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL- 17F, IL- 17 A, or both IL- 17A and IL- 17F polypeptide molecules. IL-17A and IL- 17F are cytokines that are involved in inflammatory processes and human disease. IL-17RC is a common receptor for IL- 17A and IL- 17F. The present invention includes methods of using a soluble IL- 17RC receptor, IL- 17RCx4 for treating inflammation.