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Machine translation
1. (WO2001085736) PORPHYRIN-BASED NEUTRON CAPTURE AGENTS FOR CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2001/085736    International Application No.:    PCT/US2001/015433
Publication Date: 15.11.2001 International Filing Date: 09.05.2001
Chapter 2 Demand Filed:    02.12.2001    
IPC:
A61K 41/00 (2006.01), C07D 487/22 (2006.01), C07F 5/05 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
VICENTE, M., G., H. [PT/US]; (US) (For US Only).
SHETTY, S., J. [IN/US]; (IN) (For US Only).
JAQUINOD, L. [FR/US]; (US) (For US Only).
SMITH, K., M. [US/US]; (US) (For US Only)
Inventors: VICENTE, M., G., H.; (US).
SHETTY, S., J.; (IN).
JAQUINOD, L.; (US).
SMITH, K., M.; (US)
Agent: BERLINER, Robert; Fulbright & Jaworski, L.L.P. 29th floor 865 South Figueroa Street Los Angeles, CA 90017-2576 (US).
CHURCHILL, Margaret; Fulbright & Jaworski L.L.P. 29th floor 865 S. Figueroa Street Los Angles, CA 90017-2576 (US)
Priority Data:
60/203,160 09.05.2000 US
Title (EN) PORPHYRIN-BASED NEUTRON CAPTURE AGENTS FOR CANCER THERAPY
(FR) AGENTS DE CAPTURE DE NEUTRON A BASE DE PORPHYRINE POUR LE CANCER
Abstract: front page image
(EN)The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containing 5,10,15,20-tetraphenylporphyrins bearing 25-44 % boron by weight. Preliminary in vitro evaluation of several of these compounds, using both rat and human brain tumor cell lines, shows that these compounds display very low cytotoxicities, are capable of delivering substantial amounts of boron intracellularly, and are retained for long periods of time.
(FR)L'invention concerne la synthèse d'un éventail de nouveaux 5, 10, 15, 20-tétraphénylporphyrines contenant du carboranyle de liaison carbone-carbone renfermant entre 25 et 44 % en poids de bore. Une évaluation préliminaire $i(in vitro) de plusieurs de ces composés au moyen de lignées cellulaires de tumeur du cerveau prélevées chez l'homme et le rat, montre que ces composés affichent des cytotoxycités très faibles, qu'ils peuvent distribuer des quantités importantes de bore au niveau intracellulaire, et qu'ils sont retenus durant de longues périodes de temps.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)