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1. WO2011046380 - METHOD FOR PREPARATION OF CARBAMIC ACID (R)-1-ARYL-2-TETRAZOLYL-ETHYL ESTER

Publication Number WO/2011/046380
Publication Date 21.04.2011
International Application No. PCT/KR2010/007069
International Filing Date 15.10.2010
IPC
C07D 257/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
CPC
A61K 31/41
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
C07D 257/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
C07D 257/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
04Five-membered rings
06with nitrogen atoms directly attached to the ring carbon atom
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 17/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
12containing a six-membered hetero ring
Applicants
  • SK BIOPHARMACEUTICALS CO.,LTD. [KR]/[KR] (AllExceptUS)
  • LIM, Sang Chul [KR]/[KR] (UsOnly)
  • UHM, Moo Yong [KR]/[KR] (UsOnly)
  • LEE, Dae Won [KR]/[KR] (UsOnly)
  • KIM, Hui Ho [KR]/[KR] (UsOnly)
  • LEE, Dong Ho [KR]/[KR] (UsOnly)
  • LEE, Hyun Seok [KR]/[KR] (UsOnly)
Inventors
  • LIM, Sang Chul
  • UHM, Moo Yong
  • LEE, Dae Won
  • KIM, Hui Ho
  • LEE, Dong Ho
  • LEE, Hyun Seok
Agents
  • LEE & PARK
Priority Data
61/251,86715.10.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARATION OF CARBAMIC ACID (R)-1-ARYL-2-TETRAZOLYL-ETHYL ESTER
(FR) PROCÉDÉ POUR LA PRÉPARATION D'ESTER (R)-1-ARYL-2-TÉTRAZOLYLÉTHYLIQUE DE L'ACIDE CARBAMIQUE
Abstract
(EN)
Disclosed is a method for the preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester, comprising the enantioselective enzyme reduction of the corresponding arylketone and the carbamation of the resultant alcohol.
(FR)
L'invention porte sur un procédé pour la préparation d'ester (R)-1-aryl-2-tétrazolyléthylique de l'acide carbamique, comprenant la réduction enzymatique énantiosélective de l'arylcétone correspondante et la carbamation de l'alcool ainsi obtenu.
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