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1. (WO2002050051) CHEMICAL COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2002/050051 International Application No.: PCT/GB2001/005554
Publication Date: 27.06.2002 International Filing Date: 17.12.2001
Chapter 2 Demand Filed: 11.06.2002
IPC:
A61K 45/06 (2006.01) ,C07D 281/10 (2006.01) ,C07D 417/12 (2006.01) ,C07F 9/6536 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
281
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
Seven-membered rings
04
having the hetero atoms in positions 1 and 4
08
condensed with carbocyclic rings or ring systems
10
condensed with one six-membered ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6536
having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
Applicants:
ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW)
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate London W1Y 6LN, GB (MG)
STARKE, Ingemar [SE/SE]; SE (UsOnly)
DAHLSTROM, Mikael [FI/SE]; SE (UsOnly)
BLOMBERG, David [SE/SE]; SE (UsOnly)
Inventors:
STARKE, Ingemar; SE
DAHLSTROM, Mikael; SE
BLOMBERG, David; SE
Agent:
BRYANT, Tracey; AstraZeneca Global Intellectual Property Mereside, Alderley Park Macclesfield Cheshire SK10 4TG, GB
Priority Data:
0004811-621.12.2000SE
0112592.124.05.2001GB
Title (EN) CHEMICAL COMPOUNDS
(FR) 1,5-BENZOTHIAZEPINES ET LEUR UTILISATION EN TANT QU'AGENTS ANTIHYPERLIPIDEMIE
Abstract:
(EN) The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
(FR) La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle soit R4 soit R5 est un groupe représenté par la formule (IA), ainsi qu'à des sels pharmaceutiquement acceptables, des solvates, des solvates de ces sels ainsi que des promédicaments à base de tels sels. L'invention se rapporte également à l'utilisation de ces composés en tant qu'inhibiteurs du transport des acides biliaires iléaux destinés au traitement de l'hyperlipidémie. L'invention se rapporte également à des procédés de fabrication de ces composés ainsi qu'à des compositions pharmaceutiques les contenant.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV2003-1717IS6852NO20032829PLP.363380SK7762003MXPA/a/2003/005637
KR1020030072572ZA2003/04266IL156341EP1345918JP2004516285RU02302414
US20040067933CN1481373CA2431461BRPI0116397NZ526562AU2002222228
DK1345918IN560/MUMNP/2003