(12) International Application Status Report

Received at International Bureau: 08 January 2020 (08.01.2020)

Information valid as of: 29 May 2020 (29.05.2020)

Report generated on: 18 September 2020 (18.09.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/13009525 June 2020 (25.06.2020) Japanese (JA)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/JP2019/04992119 December 2019 (19.12.2019) Japanese (JA)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
2018-238497 (JP)20 December 2018 (20.12.2018) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12P 7/22 (2006.01); C12N 1/21 (2006.01); C12N 15/60 (2006.01)

(71) Applicant(s):
RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH [JP/JP]; 9-2, Kizugawadai, Kizugawa-shi, Kyoto 6190292 (JP) (for all designated states)
SUMITOMO BAKELITE CO., LTD. [JP/JP]; 5-8, Higashi-shinagawa 2-chome, Shinagawa-ku, Tokyo 1400002 (JP) (for all designated states)

(72) Inventor(s):
INUI Masayuki
HIRAGA Kazumi
SUDA Masako
HASHIZUME Masayoshi
ISHIDA Junya

(74) Agent(s):
IKEUCHI & PARTNERS; 26th Floor, OAP TOWER, 8-30, Tenmabashi 1-chome, Kita-ku, Osaka-shi, Osaka 5306026 (JP)

(54) Title (EN): CORYNEFORM BACTERIUM TRANSFORMANT AND METHOD FOR PRODUCING 2-PHENOL ETHANOL USING SAME
(54) Title (FR): TRANSFORMANT DE BACTÉRIE CORYNÉFORME ET PROCÉDÉ DE PRODUCTION DE 2-PHÉNYLÉTHANOL L'UTILISANT
(54) Title (JA): コリネ型細菌形質転換体およびそれを用いる2-フェニルエタノールの製造方法

(57) Abstract:
(EN): Provided are: a microorganism capable of producing highly concentrated 2-phenol ethanol; and a method for efficiently producing 2-phenol ethanol using saccharides as a raw material therefor. The present invention pertains to a coryneform bacterium transformant having an activated shikimic acid pathway and having introduced thereto, in an expressible manner, a gene that codes an enzyme having phenylpyruvate decarboxylase activity. The present invention also pertains to a method for producing 2-phenyl ethanol that includes causing this coryneform bacterium transformant to react in water including saccharides.
(FR): L'invention concerne un micro-organisme capable de produire du 2-phényléthanol hautement concentré, et un procédé de production efficace de 2-phényléthanol à l'aide de saccharides en tant que matière première pour sa mise en œuvre. La présente invention concerne un transformant de bactérie corynéforme ayant une voie d'acide shikimique activée et ayant introduit, de sorte à pouvoir être exprimé, un gène codant pour une enzyme ayant une activité de phénylpyruvate décarboxylase. La présente invention concerne également un procédé de production de 2-phényléthanol consistant à amener ce transformant de bactérie corynéforme à réagir dans de l'eau comprenant des saccharides.
(JA): 2-フェニルエタノールを高濃度生産可能な微生物を提供すること、および糖類を原料として効率よく2-フェニルエタノールを製造する方法を提供する。 本開示は、シキミ酸経路が活性化されたコリネ型細菌形質転換体であって、さらに、フェニルピルビン酸デカルボキシラーゼ活性を有する酵素をコードする遺伝子が発現可能に導入されているコリネ型細菌形質転換体に関する。 本開示は、また、糖類を含む水中で本開示に係るコリネ型細菌形質転換体を反応させることを含む2-フェニルエタノールの製造方法に関する。

International search report:
Received at International Bureau: 30 March 2020 (30.03.2020) [JP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM