(12) International Application Status Report

Received at International Bureau: 25 December 2019 (25.12.2019)

Information valid as of: 11 May 2020 (11.05.2020)

Report generated on: 28 September 2020 (28.09.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/11701911 June 2020 (11.06.2020) Korean (KO)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/KR2019/01724406 December 2019 (06.12.2019) Korean (KO)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
10-2018-0157355 (KR)07 December 2018 (07.12.2018) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C07K 16/28 (2006.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); G01N 33/68 (2006.01); A61P 35/00 (2006.01)

(71) Applicant(s):
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; (Sillim-dong) 1, Gwanak-ro Gwanak-gu Seoul 08826 (KR) (for all designated states)
ABION INC. [KR/KR]; (Hanhwa Bizmetro 1-cha, Guro-dong) #915, 242, Digital-ro Guro-gu Seoul 08394 (KR) (for all designated states)

(72) Inventor(s):
SHIN, Young Kee; c/o Seoul National University (Sillim-dong) 1, Gwanak-ro Gwanak-gu Seoul 08826 (KR)
LEE, Ji Hye; c/o Seoul National University (Sillim-dong) 1, Gwanak-ro Gwanak-gu Seoul 08826 (KR)
KIM, Young Deug; c/o ABION Inc. (Hanhwa Bizmetro 1-cha, Guro-dong) #915, 242, Digital-ro Guro-gu Seoul 08394 (KR)
CHOI, Jun Young; c/o ABION Inc. (Hanhwa Bizmetro 1-cha, Guro-dong) #915, 242, Digital-ro Guro-gu Seoul 08394 (KR)

(74) Agent(s):
LEE, Hee Sook; (JS Building, Yeoksam-dong) 9th Fl., 11, Teheran-ro 33 gil Gangnam-Gu Seoul 06141 (KR)

(54) Title (EN): ANTI-C-MET AGONIST ANTIBODY AND USE THEREOF
(54) Title (FR): ANTICORPS AGONISTE ANTI-C-MET ET UTILISATION ASSOCIÉE
(54) Title (KO): 항 C-MET 아고니스트 항체 및 이의 용도

(57) Abstract:
(EN): The present invention relates to an anti-c-Met agonist antibody and a use thereof and, more specifically, to an agonist antibody or fragments thereof which specifically bind to a human-derived c-Met protein, a method for producing same, a c-Met-specific detection method using same, a composition for preventing or treating cancer comprising same, a composition for inducing the differentiation of stem cells, and a culture medium for stem cells. The method of the present invention can be effectively used to detect anti-c-Met antibodies, induce the differentiation of stem cells using the antibodies, and treat or prevent cancer.
(FR): La présente invention concerne un anticorps agoniste anti-c-Met et son utilisation et, plus particulièrement, un anticorps agoniste ou des fragments de celui-ci qui se lient de manière spécifique à une protéine c-Met dérivée d'un être humain, un procédé de production de celui-ci, un procédé de détection spécifique de c-Met l'utilisant, une composition pour la prévention ou le traitement du cancer le comprenant, une composition permettant d'induire la différenciation de cellules souches, et un milieu de culture pour cellules souches. Le procédé selon la présente invention peut être utilisé de manière efficace pour détecter des anticorps anti-c-Met, induire la différenciation de cellules souches à l'aide des anticorps, et traiter ou prévenir le cancer.
(KO): 본 발명은 항 c-Met 아고니스트 항체 및 이의 용도에 관한 것으로, 보다 상세하게는 인간 유래 c-Met 단백질에 특이적으로 결합하는 아고니스트 항체 또는 그 단편, 이의 생산방법, 이를 이용한 c-Met 특이적 검출 방법, 이를 포함하는 암 예방 또는 치료용 조성물, 줄기세포 분화 유도용 조성물 및 줄기세포용 배양 배지에 관한 것이다. 본 발명의 방법은 c-Met 항체를 검출하고, 항체를 이용하여 줄기세포 분화를 유도하고, 암을 치료 또는 예방하는 데에 유용하게 이용될 수 있다.

International search report:
Received at International Bureau: 26 March 2020 (26.03.2020) [KR]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM