(12) International Application Status Report

Received at International Bureau: 12 December 2019 (12.12.2019)

Information valid as of: 19 May 2020 (19.05.2020)

Report generated on: 26 September 2020 (26.09.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/11549011 June 2020 (11.06.2020) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/GB2019/05344005 December 2019 (05.12.2019) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
18210573.4 (EP)05 December 2018 (05.12.2018) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 38/48 (2006.01); A61P 25/00 (2006.01)

(71) Applicant(s):
IPSEN BIOPHARM LIMITED [GB/GB]; Unit 9, Ash Road Wrexham Industrial Estate Wrexham LL13 9UF (GB) (for all designated states)

(72) Inventor(s):
PORRECA, Frank; c/o IPSEN BIOPHARM LIMITED Unit 9, Ash Road Wrexham Industrial Estate Wrexham LL13 9UF (GB)
KALINICHEV, Mikhail; c/o IPSEN BIOPHARM LIMITED Unit 9, Ash Road Wrexham Industrial Estate Wrexham LL13 9UF (GB)

(74) Agent(s):
MACLEAN, Martin Robert; Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG (GB)

(54) Title (EN): TREATMENT OF SYMPTOMS OF TRAUMATIC BRAIN INJURY
(54) Title (FR): TRAITEMENT DE SYMPTÔMES D'UNE LÉSION CÉRÉBRALE TRAUMATIQUE

(57) Abstract:
(EN): Method of treating or reducing a symptom of traumatic brain injury (TBI) in a subject, comprising administering to the subject a therapeutically-effective amount of botulinum neurotoxin. Composition for use in treating or reducing a symptom of TBI in a subject comprising botulinum neurotoxin. Computer system programmed to receive information related to a subject's response to administration of botulinum neurotoxin, store that response in a database, and transmit the response to a medical practitioner. Non-transitory computer-readable storage medium storing instructions that, when executed by a computer system, causes the computer system to perform the aforementioned steps.
(FR): L'invention concerne une méthode de traitement ou de diminution d'un symptôme d'une lésion cérébrale traumatique (LCT) chez un sujet, comprenant l'administration au sujet d'une quantité thérapeutiquement efficace de neurotoxine botulique. L'invention concerne également une composition destinée à être utilisée dans le traitement ou la diminution d'un symptôme de LCT chez un sujet comprenant une neurotoxine botulique. Un système informatique est programmé pour recevoir des informations relatives à la réponse d'un sujet à l'administration de neurotoxine botulique, pour stocker cette réponse dans une base de données et pour transmettre la réponse à un médecin. Un support d'enregistrement lisible par ordinateur non transitoire qui stocke des instructions qui, lorsqu'elles sont exécutées par un système informatique, amène le système informatique à effectuer les étapes susmentionnées.

International search report:
Received at International Bureau: 31 January 2020 (31.01.2020) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM