(12) International Application Status Report

Received at International Bureau: 15 December 2019 (15.12.2019)

Information valid as of: 19 May 2020 (19.05.2020)

Report generated on: 27 September 2020 (27.09.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/11322204 June 2020 (04.06.2020) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2019/06402402 December 2019 (02.12.2019) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
62/773,266 (US)30 November 2018 (30.11.2018) Priority document received (in compliance with PCT Rule 17.1)
62/773,278 (US)30 November 2018 (30.11.2018) Priority document received (in compliance with PCT Rule 17.1)
62/773,288 (US)30 November 2018 (30.11.2018) Priority document received (in compliance with PCT Rule 17.1)
62/842,038 (US)02 May 2019 (02.05.2019) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 31/4439 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01)

(71) Applicant(s):
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 W. 116th Street New York, New York 10027 (US) (for all designated states)

(72) Inventor(s):
STOCKWELL, Brent R.; 905 West End Avenue Apt. 93 New York, New York 10025 (US)
ZASK, Arie; 21 East 90th Street New York, New York 10128 (US)
KAPLAN, Anna; 385 Fort Washington Ave. Apt. 21 New York, New York 10033 (US)

(74) Agent(s):
YANG, Ke; BRYAN CAVE LEIGHTON PAISNER LLP 1290 Avenue of the Americas New York, New York 10104 (US)

(54) Title (EN): NEUROPROTECTIVE PDI MODULATING SMALL MOLECULES AND METHODS OF USE THEREOF
(54) Title (FR): PETITES CELLULES MODULANT LE PDI NEUROPROTECTEUR ET LEURS MÉTHODES D'UTILISATION

(57) Abstract:
(EN): The present disclosure provides, inter alia, compounds and compositions having the formula (I) as defined herein. Methods of using and making such compounds and compositions are also provided. The present disclosure further provides screening methods, including detectable probes as well as diagnostic methods and methods for monitoring the progress of a disease, such as a neurodegenerative disease.
(FR): La présente invention concerne, entre autres, des composés et des compositions répondant à la formule (I) telle que définie dans la description. L'invention concerne également des méthodes d'utilisation et de production de ces composés et compositions. La présente invention concerne en outre des méthodes de criblage, faisant appel à des sondes détectables ainsi que des méthodes de diagnostic et des méthodes de surveillance de la progression d'une maladie, telle qu'une maladie neurodégénérative.

International search report:
Received at International Bureau: 10 May 2020 (10.05.2020) [US]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM