(12) International Application Status Report

Received at International Bureau: 14 December 2019 (14.12.2019)

Information valid as of: 08 May 2020 (08.05.2020)

Report generated on: 22 September 2020 (22.09.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/11262704 June 2020 (04.06.2020) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2019/06299225 November 2019 (25.11.2019) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
62/772,445 (US)28 November 2018 (28.11.2018) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 31/7068 (2006.01); A61P 35/00 (2006.01); A61P 9/00 (2006.01)

(71) Applicant(s):
EVOL SCIENCE LLC [US/US]; 727 Norristown Road Spring House Innovation Park-Building 3, Suite 102 Lower Gwynedd, Pennsylvania 19002 (US) (for all designated states)

(72) Inventor(s):
BHATTACHARJEE, Vikram; 727 Norristown Road Spring House Innovation Park-Building 3, Suite 102 Lower Gwynedd, Pennsylvania 19002 (US)

(74) Agent(s):
SCOLNICK, Daniel M.; Pepper Hamilton LLP 400 Berwyn Park 899 Cassatt Road Berwyn, Pennsylvania 19312 (US)

(54) Title (EN): COMBINATIONS OF PARP INHIBITORS AND MAPK ACTIVATORS TO TREAT CANCER
(54) Title (FR): COMBINAISONS D'INHIBITEURS PARP ET ACTIVATEURS MAPK POUR LE TRAITEMENT DU CANCER

(57) Abstract:
(EN): This application describes compounds, compositions, and combinations thereof that can be used to treat cancer, such as cancers with and without BRCA, BRAF and/or RAS mutations.
(FR): L'invention concerne des composés, des compositions, et des combinaisons de ceux-ci qui peuvent être utilisés pour traiter le cancer, notamment des cancers avec et sans mutations BRCA, BRAF et/ou RAS.

International search report:
Received at International Bureau: 06 March 2020 (06.03.2020) [US]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM