(12) International Application Status Report

Received at International Bureau: 01 August 2019 (01.08.2019)

Information valid as of: 22 November 2019 (22.11.2019)

Report generated on: 24 January 2021 (24.01.2021)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2020/02332430 January 2020 (30.01.2020) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/US2019/04271820 July 2019 (20.07.2019) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
62/701,814 (US)22 July 2018 (22.07.2018) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 31/428 (2006.01); C07D 277/82 (2006.01); A61P 25/28 (2006.01)

(71) Applicant(s):
BIOHAVEN THERAPEUTICS LTD. [US/US]; 215 Church Street New Haven, Connecticut 06510 (US) (for all designated states)

(72) Inventor(s):
CORIC, Vladimir; 215 Church Street New Haven, Connecticut 06510 (US)
BERMAN, Robert; 215 Church Street New Haven, Connecticut 06510 (US)
QURESHI, Irfan; 215 Church Street New Haven, Connecticut 06510 (US)

(74) Agent(s):
VOLLES, Warren K.; IPRAXUS LEGAL, LLC P.O. Box 689 67 Sterling Hill Road Old Lyme, Connecticut 06371 (US)

(54) Title (EN): USE OF RILUZOLE PRODRUGS TO TREAT ALZHEIMER'S DISEASE
(54) Title (FR): UTILISATION DE PROMÉDICAMENTS À BASE DE RILUZOLE POUR TRAITER LA MALADIE D'ALZHEIMER

(57) Abstract:
(EN): Disclosed are methods of treating Alzheimer's Disease by administering to a patient in need thereof a riluzole prodrug such as troriluzole. Pharmaceutical compositions and kits including the riluzole prodrugs are also disclosed.
(FR): L'invention concerne des procédés de traitement de la maladie d'Alzheimer par administration à un patient qui en a besoin d'un promédicament à base de riluzole tel que le troriluzole. L'invention concerne également des compositions pharmaceutiques et des kits comprenant les promédicaments à base de riluzole.

International search report:
Received at International Bureau: 19 November 2019 (19.11.2019) [US]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM

Declarations:
Declaration made as applicant's entitlement, as at the international filing date, to apply for and be granted a patent (Rules 4.17(ii) and 51bis.1(a)(ii)), in a case where the declaration under Rule 4.17(iv) is not appropriate
Declaration made as applicant's entitlement, as at the international filing date, to claim the priority of the earlier application, where the applicant is not the applicant who filed the earlier application or where the applicant's name has changed since the filing of the earlier application (Rules 4.17(iii) and 51bis.1(a)(iii))
Declaration of inventorship (Rules 4.17(iv) and 51bis.1(a)(iv)) for the purposes of the designation of the United States of America