(12) International Application Status Report

Received at International Bureau: 27 November 2018 (27.11.2018)

Information valid as of: 18 February 2019 (18.02.2019)

Report generated on: 18 February 2020 (18.02.2020)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2019/09221516 May 2019 (16.05.2019) English (EN)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/EP2018/08083209 November 2018 (09.11.2018) English (EN)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
1718631.3 (GB)10 November 2017 (10.11.2017) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
A61K 45/06 (2006.01); A61K 31/7036 (2006.01); A61P 31/04 (2006.01); A61K 41/00 (2006.01)

(71) Applicant(s):
PCI BIOTECH AS [NO/NO]; Ullernchausseen 64 0379 Oslo (NO) (for all designated states)
ACADEMISCH MEDISCH CENTRUM [NL/NL]; Meibergdreef 9 1105 AZ Amsterdam (NL) (for all designated states)

(72) Inventor(s):
HØGSET, Anders; c/o PCI Biotech AS Ullernchausseen 64 0379 Oslo (NO)
ZAAT, Sebastian A.J.; Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam (NL)
ZHANG, Xiaolin; Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam (NL)

(74) Agent(s):
JONES, Elizabeth Louise; St Bride's House 10 Salisbury Square London Greater London EC4Y 8JD (GB)

(54) Title (EN): COMPOSITION FOR THE TREATMENT OF INTRACELLULAR BACTERIAL INFECTION
(54) Title (FR): COMPOSITION POUR LE TRAITEMENT D'UNE INFECTION BACTÉRIENNE INTRACELLULAIRE

(57) Abstract:
(EN): The present invention provides a method of treating or preventing an intracellular bacterial infection, comprising contacting the cell(s) which are infected with an antibacterial agent and a photosensitizing agent and irradiating the cell(s) with light of a wavelength effective to activate the photosensitizing agent, wherein the antibacterial agent is released into the cytosol of the cell(s) and kills, damages or prevents the replication of bacteria in said cell(s). The invention also provides related uses, and compositions, products and kits for the same.
(FR): La présente invention concerne une méthode de traitement ou de prévention d'une infection bactérienne intracellulaire, comprenant la mise en contact de la ou des cellules qui sont infectées par un agent antibactérien et un agent photosensibilisant et l'irradiation de la ou des cellules avec une lumière d'une longueur d'onde efficace pour activer l'agent photosensibilisant, l'agent antibactérien étant libéré dans le cytosol de la ou des cellules et tue, endommager ou empêcher la réplication de bactéries dans ladite ou lesdites cellules. L'invention concerne également des utilisations associées, et des compositions, des produits et des kits associés.

International search report:
Received at International Bureau: 12 February 2019 (12.02.2019) [EP]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM