(12) International Application Status Report

Received at International Bureau: 06 November 2018 (06.11.2018)

Information valid as of: 24 January 2019 (24.01.2019)

Report generated on: 18 September 2019 (18.09.2019)

(10) Publication number: (43) Publication date: (26) Publication language:
WO 2019/04328207 March 2019 (07.03.2019) Spanish (ES)

(21) Application number: (22) Filing date: (25) Filing language:
PCT/ES2018/07058204 September 2018 (04.09.2018) Spanish (ES)

(31) Priority number(s): (32) Priority date(s): (33) Priority status:
P201731066 (ES)04 September 2017 (04.09.2017) Priority document received (in compliance with PCT Rule 17.1)

(51) International Patent Classification:
C12N 5/077 (2010.01); C12N 5/0775 (2010.01); A61K 35/12 (2015.01); A61K 35/28 (2015.01)

(71) Applicant(s):
INSTITUTO DE SALUD CARLOS III [ES/ES]; Avenida de Monforte de Lemos, 5 28029 Madrid (ES) (for all designated states)

(72) Inventor(s):
GARCÍA CASTRO, Javier; Instituto de Salud Carlos III Carretera de Majadahonda-Pozuelo, Km. 2.200 28220 Madrid (ES)
CEJALVO GOYANES, Teresa; Instituto de Salud Carlos III Carretera de Majadahonda-Pozuelo, Km. 2.200 28220 Madrid (ES)
PERISÉ BARRIOS, Ana Judith; Instituto de Salud Carlos III Carretera de Majadahonda-Pozuelo, Km. 2.200 28220 Madrid (ES)
GAMBERA, Stefano; Instituto de Salud Carlos III Carretera de Majadahonda-Pozuelo, Km. 2.200 28220 Madrid (ES)
MORALES MOLINA, Álvaro; Instituto de Salud Carlos III Carretera de Majadahonda-Pozuelo, Km. 2.200 28220 Madrid (ES)

(74) Agent(s):
FUSTER, Gustavo; Paseo de la Castellana 140 Planta 3ª. Edificio Lima 28046 Madrid (ES)

(54) Title (EN): COMBINED PRODUCT COMPRISING A MODIFIED MESENCHYMAL STEM CELL AND AN ANTIGENIC SUBSTANCE
(54) Title (FR): PRODUIT DE COMBINAISON COMPRENANT UNE CELLULE SOUCHE MÉSENCHYMATEUSE MODIFIÉE ET UNE SUBSTANCE ANTIGÈNE
(54) Title (ES): PRODUCTO DE COMBINACIÓN QUE COMPRENDE UNA CÉLULA MADRE MESENQUIMAL MODIFICADA Y UNA SUSTANCIA ANTIGÉNICA

(57) Abstract:
(EN): The present application discloses a combined product for the treatment of cancer. The combined product comprises (i) a modified mesenchymal stem cell, and (ii) an antigenic substance. Moreover, the present application also provided a method for producing a modified mesenchymal stem cell comprising an intracellular parasite and a kit comprising (a) a mesenchymal stem cell, (b) an antigenic substance and (c) an inhibitor for a receptor of the Toll-like type and/or an inhibitor of the gene MyD88.
(FR): La présente invention concerne un produit de combinaison pour le traitement de cancer. Le produit de combinaison comprend (i) une cellule souche mésenchymateuse modifiée, et (ii) une substance antigène. En outre, ladite invention concerne aussi une méthode de production d'une cellule souche mésenchymateuse modifiée comprenant un parasite intracellulaire et un kit comprenant (a) une cellule souche mésenchymateuse, (b) une substance antigène, et (c) un inhibiteur du récepteur de type Toll-like et/ou du gène MyD88.
(ES): La presente solicitud proporciona un producto de combinación para el tratamiento de cáncer. El producto de combinación comprende (i) una célula madre mesenquimal modificada, y (ii) una sustancia antigénica. Además,la presente solicitud también proporciona un método para la producción de una célula madre mesenquimal modificada que comprende un parásito intracelular y un kit que comprende (a) una célula madre mesenquimal, (b) una sustancia antigénica y (c) un inhibidor del receptor de tipo Toll-like y/o del gen MyD88.

International search report:
Received at International Bureau: 18 January 2019 (18.01.2019) [ES]

International Report on Patentability (IPRP) Chapter II of the PCT:
Not available

(81) Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, RU, TJ, TM